A5044312512- Cardiac Valve Diseases and Treatments
- Mechanical Circulatory Support Devices
- Cardiac Structural Anomalies and Repair
- Cardiac, Anesthesia and Surgical Outcomes
- Infective Endocarditis Diagnosis and Management
- Congenital Heart Disease Studies
- Aortic Disease and Treatment Approaches
- Cardiovascular Function and Risk Factors
- Cardiac Arrhythmias and Treatments
- Cardiac Arrest and Resuscitation
- Aortic aneurysm repair treatments
- Cardiovascular Effects of Exercise
- Transplantation: Methods and Outcomes
- Cardiac and Coronary Surgery Techniques
- Enhanced Recovery After Surgery
- Anesthesia and Pain Management
- Atherosclerosis and Cardiovascular Diseases
- Diabetes Management and Research
- Cardiac Imaging and Diagnostics
- Intramuscular injections and effects
- Hemodynamic Monitoring and Therapy
- Immune Cell Function and Interaction
- Abdominal vascular conditions and treatments
- Acute Kidney Injury Research
- Atrial Fibrillation Management and Outcomes
Children's Hospital Colorado
2021-2025
University of Colorado Denver
2021-2025
University of Sheffield
2021-2025
University of Virginia
2014-2023
Children's Hospital of The King's Daughters
2023
University of Colorado Anschutz Medical Campus
2021-2022
University of Virginia Health System
2016-2020
University of Illinois at Springfield
2018
Digital Scholar (United States)
2018
University of Virginia Medical Center
2018
Objective— B-cell depletion therapy is widely used for treatment of cancers and autoimmune diseases. B cells are abundant in abdominal aortic aneurysms (AAA); however, it unknown whether affects AAA growth. Using experimental models murine AAA, we aim to examine the effect on formation. Approach Results— Wild-type or apolipoprotein E–knockout mice were treated with mouse monoclonal anti-CD20 control antibodies subjected an elastase perfusion angiotensin II infusion model induce respectively....
Abstract Aims Hypoglycaemia causes abnormal cardiac repolarisation, which has been related to sympathoadrenal activation. We examined whether individuals with type 1 diabetes (T1D) and impaired awareness of hypoglycaemia (IAH) were protected against proarrhythmogenic alterations on their electrocardiogram during clinical episodes hypoglycaemia. Methods Adults T1D IAH underwent 96 h simultaneous ambulatory blinded continuous interstitial glucose (IG) monitoring. Measures repolarisation heart...
This study investigated the performance of a magnetically levitated, intravascular axial flow blood pump for mechanical circulatory support thousands Fontan patients in desperate need therapeutic alternative. Four models extracardiac, total cavopulmonary connection (TCPC) configuration were evaluated to formulate numerical predictions: an idealized TCPC, patient-specific TCPC per magnetic resonance imaging data, and each these two having inferior vena cava (IVC). A lumped parameter model...
Aortic valve repair can be limited by inadequate leaflet tissue for proper coaptation. Various kinds of pericardium have been used cusp augmentation, but most failed because degeneration. A more durable substitute is needed.In this report, 8 consecutive cases are presented in which autologous ascending aortic was to augment native cusps during repair. Biologically, wall a living that could exceptional durability as substitute. Techniques insertion described detail, along with procedural...
Abstract This numerical study examined the performance of an intravascular axial flow blood pump for mechanical hemodynamic support patients in setting Fontan failure, which presently has few treatment options. Three anatomically accurate geometries total cavopulmonary connection (TCPC) were generated using patients' magnetic resonance imaging data. These patient‐specific geometries, as well idealized version with cylindrical vessels, computationally analyzed and without a inferior vena...
This study examined the interactive fluid dynamics between a cavopulmonary assist device and univentricular Fontan circulation. We conducted two-dimensional particle image velocimetry measurements on an idealized total connection (TCPC) with axial pump prototype intravascularly inserted into inferior vena cava (IVC) then in IVC superior (SVC) for dual-pump support case. The glass model of TCPC consisted rigid vessels having diameter 13.4 mm one-diameter vessel offset at junction. Fluid...
Failing single ventricle physiology represents an ongoing challenge in mechanical assist device development, requiring pressure augmentation the cavopulmonary circuit, reduction of systemic venous pressure, and increased cardiac output to achieve hemodynamic stabilization. To meet these requirements, we are developing a percutaneously-placed, axial flow blood pump support ailing adolescents adults. We have modified outer cage serve as both protective functional design component. This study...
Thousands of mechanical blood pumps are currently providing circulatory support, and the incidence their use continues to increase each year. As becomes more pervasive in treatment those patients with congestive heart failure, critical advances design features address known limitations integration novel technologies become imperative. To advance current state-of-the-art pump design, this study investigates inclusion pitch-adjusting blade intravascular as a means energy transfer; an approach...