Abstract: This study explores a quantitative evaluation of blood damage that occurs in continuous flow left ventricular assist device due to fluid stress. Computational dynamics (CFD) analysis is used track the shear stress history 388 particle streaklines. The accumulation and exposure time integrated along streaklines evaluate levels trauma. analysis, which includes viscous turbulent stresses, provides statistical estimate possible cells flowing through pump. In vitro normalized index...

Computational models of the cardiovascular system continue to increase in complexity. As more elements physiology are captured multiscale models, there is a need efficiently integrate subsystems. The objective this study demonstrate effectiveness coupling methodology, called functional mock-up interface (FMI), as applied modeling. model composed two subsystems: computational fluid dynamics (CFD) coupled lumped parameter (LPM). LPM packaged using FMI standard and imported into CFD subsystem...

ABSTRACT Background Safe and effective pediatric blood pumps continue to lag far behind those developed for adults. To address this growing unmet clinical need, we are developing a hybrid, continuous‐flow, magnetically levitated, total artificial heart (TAH). Our hybrid TAH design, the Dragon Heart (DH), integrates both an axial flow centrifugal pump within single, compact housing. The is embedded in central hub region of pump, rotate around common axis, while maintaining separate fluid...

This study explores a quantitative evaluation of blood damage that occurs in continuous flow left ventricular assist device (LVAD) due to fluid stress. Computational dynamics (CFD) analysis is used track the shear stress history 388 particle streaklines. The accumulation and exposure time integrated along streaklines evaluate levels trauma. analysis, which includes viscous turbulent stresses, provides statistical estimate possible cells flowing through pump. Since experimental data for...

Abstract To provide a viable bridge‐to‐transplant, bridge‐to‐recovery, or bridge‐to‐surgical reconstruction for patients with failing Fontan physiology, we are developing collapsible, percutaneously inserted, magnetically levitated axial flow blood pump to support the cavopulmonary circulation in adolescent and adult patients. This unique will augment pressure thus inferior vena cava through lungs ameliorate poor hemodynamics associated univentricular circulation. Computational fluid...

Fluid flow is an integral part of microfluidic and organ-on-chip technology, ideally providing biomimetic fluid, cell, nutrient exchange as well physiological or pathological shear stress. Currently, many the pumps that actively perfuse fluid at rates are incompatible with use inside cell culture incubators, require tubing connections, too large to run devices in a confined space. To address these issues, we developed user-friendly impeller pump uses 3D-printed device recirculate cells...

Abstract: Thousands of adult cardiac failure patients may benefit from the availability an effective, long‐term ventricular assist device (VAD). We have developed a fully implantable, axial flow VAD (LEV‐VAD) with magnetically levitated impeller as viable option for these patients. This pump's streamlined and unobstructed blood path provides its unique design facilitates continuous washing all surfaces contacting blood. One internal fluid region, diffuser, is extremely important to ability...

Thousands of cardiac failure patients per year in the United States could benefit from long-term mechanical circulatory support as destination therapy. To provide an improvement over currently available devices, we have designed a fully implantable axial-flow ventricular assist device with magnetically levitated impeller (LEV-VAD). In contrast to LEV-VAD has unobstructed blood flow path and no secondary regions, generating substantially less retrograde stagnant flow. The pump design included...

Mechanical circulatory support options for infants and children are very limited in the United States. Existing systems have proven successful short-term pediatric assist, but not completely as a bridge-to-transplant or bridge-to-recovery. To address this substantial need alternative mechanical we developing novel, magnetically levitated, axial flow ventricular assist device (PVAD) intended longer-term support. Three major numerical design optimization phases been completed. A prototype was...

This study investigated the performance of a magnetically levitated, intravascular axial flow blood pump for mechanical circulatory support thousands Fontan patients in desperate need therapeutic alternative. Four models extracardiac, total cavopulmonary connection (TCPC) configuration were evaluated to formulate numerical predictions: an idealized TCPC, patient-specific TCPC per magnetic resonance imaging data, and each these two having inferior vena cava (IVC). A lumped parameter model...

Abstract Clinical studies using total artificial hearts (TAHs) have demonstrated that pediatric and adult patients derive quality‐of‐life benefits from this form of therapy. Two clinically‐approved TAHs other pumps under development, however, design challenges limitations, including thromboembolic events, neurologic impairment, infection risk due to large size percutaneous drivelines, lack ambulation, name a few. To address these we are developing hybrid‐design, continuous‐flow, implantable...

A ventricular assist device (VAD), which is a miniaturized axial flow pump from the point of view mechanism, has been designed and studied in this report. It consists an inducer, impeller, diffuser. The main design objective VAD to produce with streamlined, idealized, nonobstructing blood path. magnetic bearings are adapted so that impeller completely magnetically levitated. operates under transient conditions because spinning movement pulsatile inlet rate. method, procedure, iterations...

Thousands of pediatric patients suffering from heart failure would benefit longer-term mechanical circulatory support. There are, however, few support systems available in the United States as viable assist alternatives for these patients. Therefore, we have designed and developed an axial flow ventricular device (PVAD) with impeller that is fully suspended by magnetic bearings. This blood pump to generate 0.5–4 L/min pressure rises 50–95 mm Hg over 6,000–9,000 rpm. We performed four major...

Abstract: Longer‐term (>2 weeks) mechanical circulatory support will provide an improved quality of life for thousands pediatric cardiac failure patients per year in the United States. These suffer from severe congenital or acquired heart disease complicated by congestive failure. There are currently very few systems available States as viable options this population. For that reason, we have designed axial flow ventricular assist device (PVAD) with impeller is fully suspended magnetic...

Millions of patients, from infants to adults, are diagnosed with congestive heart failure each year all over the world. A limited number donor hearts available for these patients results in a tremendous demand alternative, supplemental circulatory support form artificial pumps or ventricular assist devices (VADs). The development procedure such device requires careful consideration biophysical factors, as biocompatibility, haemolysis, thrombosis, implantability, physiologic control...