Norman Mangner
A5039894326- Cardiac Valve Diseases and Treatments
- Infective Endocarditis Diagnosis and Management
- Mechanical Circulatory Support Devices
- Cardiovascular Function and Risk Factors
- Cardiac Structural Anomalies and Repair
- Cardiac Arrest and Resuscitation
- Coronary Interventions and Diagnostics
- Cardiac Imaging and Diagnostics
- Cardiovascular and exercise physiology
- Atrial Fibrillation Management and Outcomes
- Aortic Disease and Treatment Approaches
- Muscle Physiology and Disorders
- Antiplatelet Therapy and Cardiovascular Diseases
- Acute Myocardial Infarction Research
- Cardiovascular Effects of Exercise
- Adipose Tissue and Metabolism
- Heart Failure Treatment and Management
- Nutrition and Health in Aging
- Cardiomyopathy and Myosin Studies
- Cardiac pacing and defibrillation studies
- Muscle metabolism and nutrition
- Exercise and Physiological Responses
- Antimicrobial Resistance in Staphylococcus
- Cardiovascular Disease and Adiposity
- Heart Rate Variability and Autonomic Control
Technische Universität Dresden
2018-2025
University Hospital Carl Gustav Carus
2020-2025
Rigshospitalet
2024
University Medical Center Hamburg-Eppendorf
2024
Aarhus University Hospital
2024
Copenhagen University Hospital
2024
University of Copenhagen
2024
University of Southern Denmark
2024
Universität Hamburg
2024
Heinrich Heine University Düsseldorf
2024
Small studies have suggested that high-intensity interval training (HIIT) is superior to moderate continuous (MCT) in reversing cardiac remodeling and increasing aerobic capacity patients with heart failure reduced ejection fraction. The present multicenter trial compared 12 weeks of supervised interventions HIIT, MCT, or a recommendation regular exercise (RRE).Two hundred sixty-one left ventricular fraction ≤35% New York Heart Association class II III were randomly assigned HIIT at 90% 95%...
The effects of temporary mechanical circulatory support with a microaxial flow pump on mortality among patients ST-segment elevation myocardial infarction (STEMI) complicated by cardiogenic shock remains unclear.
<h3>Importance</h3> Stroke remains a major predictor of mortality after transcatheter aortic valve implantation (TAVI). Cerebral protection devices might reduce brain injury as determined by diffusion-weighted magnetic resonance imaging (DWMRI). <h3>Objective</h3> To determine the effect cerebral device on number and volume lesions in patients undergoing TAVI. <h3>Design, Setting, Participants</h3> Investigator-initiated, single center, blinded, randomized clinical trial higher-risk with...
Remote ischaemic conditioning (RIC) and postconditioning (PostC) are both potent activators of innate protection against ischaemia-reperfusion injury have demonstrated cardioprotection in experimental clinical ST-elevation myocardial infarction (STEMI) trials. However, their combined effects not been studied detail. The aim this study was to evaluate if the co-application intrahospital RIC PostC has a more powerful effect on salvage compared with either alone or control.This prospective,...
In patients with ST-segment elevation myocardial infarction (STEMI) multivessel coronary artery disease, the time at which complete revascularization of nonculprit lesions should be performed remains unknown. Download a PDF Research Summary. We an international, open-label, randomized, noninferiority trial 37 sites in Europe. Patients hemodynamically stable condition who had STEMI and disease were randomly assigned to undergo immediate percutaneous intervention (PCI; group) or PCI culprit...
Background— Muscle wasting occurs in both chronic heart failure (CHF) and normal aging contributes to exercise intolerance increased morbidity/mortality. However, the molecular mechanisms of muscle atrophy CHF their interaction with are still largely unknown. We therefore measured activation ubiquitin-proteasome system lysosomal pathway intracellular proteolysis biopsies patients healthy controls two age strata assessed age-dependent effects a 4-week endurance training program on...
A reduction in number and function of endothelial progenitor cells (EPCs) occurs both physiologic aging chronic heart failure (CHF). We assessed whether disease have additive effects on EPCs or beneficial exercise training are diminished old age. randomized 60 patients with stable CHF referent controls to a control group. To detect possible we included subjects below 55 (young) above 65 years (older). Subjects the group exercised four times daily at 60% 70% VO2max for weeks under...
Chronic heart failure (CHF) is commonly associated with muscle atrophy and increased inflammation. Irisin, a myokine proteolytically processed by the fibronectin type III domain containing 5 (FNDC5) gene suggested to be Peroxisome proliferator-activated receptor gamma coactivator (PGC)-1α activated, modulates browning of adipocytes related mass. Therefore, we investigated whether skeletal FNDC5 expression in CHF was reduced if this mediated inflammatory cytokines and/or angiotensin II...
A well-developed coronary collateral circulation provides a potential source of blood supply in artery disease. However, the prognostic importance and functional relevance collaterals is controversial with association between exercise training growth still unclear.This prospective, open-label study randomly assigned 60 patients significant disease (fractional flow reserve ≤0.75) to high-intensity (group A, 20 patients) or moderate-intensity B, for 4 weeks control group C, patients). The...
Abstract Background Muscle ring finger 1 (MuRF1) is a muscle‐specific ubiquitin E3 ligase activated during clinical conditions associated with skeletal muscle wasting. Yet, there remains paucity of therapeutic interventions that directly inhibit MuRF1 function, particularly in vivo . The current study, therefore, developed novel compound targeting the central coiled coil domain to wasting cardiac cachexia. Methods We identified small molecules interfere MuRF1–titin interaction from 130 000...
Background: Patients at high-bleeding risk (HBR) undergoing percutaneous coronary intervention represent a challenging patient population. The use of drug-coated balloon (DCB) allows shorter duration dual antiplatelet therapy compared with drug-eluting stents (DES) and reduces thrombotic due to the absence permanent implant. present analysis aimed investigate if effect DCB versus DES differed between patients without HBR treated in small arteries. Methods: This prespecified subgroup...
Despite its high incidence and mortality risk, there is no evidence-based treatment for non-ischaemic cardiogenic shock (CS). The aim of this study was to evaluate the use mechanical circulatory support (MCS) CS treatment.In multicentre, international, retrospective study, data from 890 patients with CS, defined as due severe de-novo or acute-on-chronic heart failure need urgent revascularization, treated without active MCS, were collected. association between MCS primary endpoint 30-day...
Background: In the Danish–German Cardiogenic Shock (DanGer Shock) trial, use of a microaxial flow pump (mAFP) in patients with ST-segment elevation myocardial infarction (STEMI)-related CS led to lower all-cause mortality but higher rates renal replacement therapy (RRT). this prespecified analysis, and predictors acute kidney injury (AKI) RRT were assessed. Methods: international, randomized, open label, multicenter 355 adult STEMI-CS randomized mAFP (N=179) or standard care alone (N=176)....