A5063988221- Cardiomyopathy and Myosin Studies
- Cardiac Valve Diseases and Treatments
- Cardiovascular Function and Risk Factors
- Cardiac Structural Anomalies and Repair
- Infective Endocarditis Diagnosis and Management
- Cardiac Imaging and Diagnostics
- Signaling Pathways in Disease
- Cardiovascular Effects of Exercise
- Cardiac Fibrosis and Remodeling
- Heart Failure Treatment and Management
- Advanced MRI Techniques and Applications
- Cardiac electrophysiology and arrhythmias
- Mechanical Circulatory Support Devices
- Cardiac Arrest and Resuscitation
- Atrial Fibrillation Management and Outcomes
- Cardiac Arrhythmias and Treatments
- Ion channel regulation and function
- Innovations in Medical Education
- Viral Infections and Immunology Research
- Coronary Interventions and Diagnostics
- Firm Innovation and Growth
- GDF15 and Related Biomarkers
- Acute Ischemic Stroke Management
- Hippo pathway signaling and YAP/TAZ
- Problem and Project Based Learning
Heidelberg University
2006-2025
University Hospital Heidelberg
2006-2025
German Centre for Cardiovascular Research
2016-2024
University of Lübeck
2013-2023
University Hospital Schleswig-Holstein
2013-2023
Clinical Research Center Kiel
2015-2021
Kiel University
2014-2016
Heart and Diabetes Center North Rhine-Westphalia
2013
University Hospital Ulm
2010
Universität Hamburg
2010
Data from the Women's Health Study show that serum levels of growth-differentiation factor-15 (GDF-15), a distant member transforming growth factor-beta superfamily, are an independent risk indicator for adverse cardiovascular events. However, cellular sources, upstream regulators, and functional effects GDF-15 in system have not been elucidated. We identified by cDNA expression array analysis as gene is strongly upregulated nitrosative stress cultured cardiomyocytes isolated 1- to 3-day-old...
Venoarterial extracorporeal membrane oxygenation (VA-ECMO) is increasingly used to treat cardiogenic shock. However, VA-ECMO might hamper myocardial recovery. The Impella unloads the left ventricle. This study aimed evaluate whether ventricular unloading in patients with shock treated was associated lower mortality.Data from 686 consecutive or without using an at 16 tertiary care centers 4 countries were collected. association between and 30-day mortality assessed by Cox regression models a...
Journal Article The pH of Rat Tumors Measured In Vivo Get access M. Eden, Eden National Cancer Institute,3Bethesda, Md. Search for other works by this author on: Oxford Academic PubMed Google Scholar B. Haines, Haines H. Kahler JNCI: the Institute, Volume 16, Issue 2, October 1955, Pages 541–556, https://doi.org/10.1093/jnci/16.2.541 Published: 01 1955 history Received: 12 May
Rationale and Objective: The M-band represents a transverse structure in the center of sarcomeric A-band provides an anchor for myosin-containing thick filaments. In contrast to other structures, eg, Z-disc, only few M-band–specific proteins have been identified date, its exact molecular composition remains unclear. Methods Results: Using bioinformatic approach identify novel heart- muscle-specific genes, we found leucine rich protein, myomasp ( Myo sin-interacting, M -band- ssociated s...
Objective Ventricular secondary mitral regurgitation (SMR) (Carpentier type IIIb) results from left ventricular (LV) remodelling, displacement of papillary muscles and tethering leaflets. The most appropriate treatment approach remains controversial. We aimed to assess the safety efficacy standardised relocation both (subannular repair) at 1-year follow-up (FU). Methods REFORM-MR (Reform-Mitral Regurgitation) is a prospective, multicentre registry that enrolled consecutive patients with SMR...
The flow convergence method includes calculation of the proximal isovelocity surface area (PISA) and is widely used to classify mitral regurgitation (MR) with echocardiography. It constitutes a primary decision factor for determination treatment should therefore be robust quantification method. However, it known its tendency underestimate MR dependence on user expertise. present work systematically compares different pulsatile profiles arising from orifices using transesophageal...
The intercalated disc (ID) is a "hot spot" for heart disease, as several ID proteins have been found mutated in cardiomyopathy. Myozap recent addition to the list of and has implicated serum-response factor signaling. To elucidate cardiac consequences targeted deletion myozap vivo, we generated myozap-null mutant (Mzp(-/-)) mice. Although Mzp(-/-) mice did not exhibit baseline phenotype, increased biomechanical stress due pressure overload led accelerated hypertrophy, accompanied by...
Veno-arterial extracorporeal membrane oxygenation therapy (VA-ECMO) restores circulation and tissue in cardiogenic shock (CS) patients, but can also lead to complications. This study aimed quantify VA-ECMO complications analyse their association with overall survival as well favourable neurological outcome (cerebral performance categories 1 + 2). All-comer patients CS treated were retrospectively enrolled from 16 centres four countries (2005-2019). Neurological, bleeding, ischaemic adverse...
Abstract Calcium signalling plays a critical role in the pathogenesis of heart failure. Here we describe cardiac protein named Myoscape/FAM40B/STRIP2, which directly interacts with L-type calcium channel. Knockdown Myoscape cardiomyocytes decreases transients associated smaller Ca 2+ amplitudes and lower diastolic content. Likewise, channel currents are significantly diminished on ablation, downregulation reduces contractility cardiomyocytes. Conversely, overexpression increases global...
Recurrent stroke is considered to increase the incidence of severe disability and death. For correct risk assessment patient management it essential identify origin at an early stage. Transthoracic echocardiography (TTE) initial standard care for evaluating patients in whom a cardioembolic source (CES) suspected but its diagnostic capability limited. Transesophageal (TEE) as gold standard; however, this approach time consuming, semi-invasive not always feasible. We hypothesized that adding...
Myocardial failure is associated with adverse remodeling which includes apoptotic loss of cardiomyocytes, hypertrophy as well alterations in cell-cell contacts. Striatin-interacting phosphatase and kinase (STRIPAK) complexes their Mst4 have been linked to the development different diseases. The role targets cardiomyocytes not investigated, yet.Multi tissue immunoblot experiments show highly enriched Mst4-expression rodent hearts. Analyses human biopsy samples from patients suffering dilated...
Transcatheter aortic valve implantation (TAVI) is increasingly being used in younger patients and those with lower peri-procedural risk, meaning more will live long enough to experience structural deterioration (SVD) of the bioprosthesis, indicating repeated TAVI. Experience TAVI-transcatheter heart (THV) into an index THV limited. This registry aims assess short-term safety, efficacy durability
Abstract The objective of this study was to identify unknown modulators Calcineurin (Cn)-NFAT signaling. Measurement NFAT reporter driven luciferase activity therefore utilized screen a human cardiac cDNA-library (~10 7 primary clones) in C2C12 cells through serial dilutions until single clones could be identified. This extensive screening strategy culminated the identification SUMO2 as most efficient Cn-NFAT activator. SUMO2-mediated activation signaling cardiomyocytes translated into...
We report 1-year safety and clinical outcomes in patients <60 years undergoing bioprosthetic surgical aortic valve intervention.The INSPIRIS RESILIA Durability Registry is a prospective, multicentre registry to assess of years. Patients with planned SAVR or without concomitant replacement the ascending aorta and/or coronary bypass surgery were included. Time-related safety, haemodynamic performance quality life (QoL) at 1 year assessed.A total 421 documented mean age 53.5 years, 76.5% being...
Minimally invasive mitral valve surgery (MIMVS) and transcatheter edge-to-edge repair (TEER) are complex procedures used to treat (MV) pathologies, but with limited training opportunities available. To enable training, a realistic hemodynamic environment is needed. In this work we aimed develop validate simulator that enables investigation of MV pathologies their by MIMVS TEER in setting.
Abstract OBJECTIVES We investigated the sex-related difference in characteristics and 2-year outcomes after surgical aortic valve replacement (SAVR) by propensity-score matching (PSM). METHODS Data from 2 prospective registries, INSPIRIS RESILIA Durability Registry (INDURE) IMPACT, were merged, resulting a total of 933 patients: 735 males 253 females undergoing first-time SAVR. The PSM was performed to assess impact sex on SAVR outcomes, yielding 433 243 with comparable baseline...