A5042905889- Cardiac Valve Diseases and Treatments
- Aortic Disease and Treatment Approaches
- Infective Endocarditis Diagnosis and Management
- Cardiac and Coronary Surgery Techniques
- Cardiac Structural Anomalies and Repair
- Cardiac, Anesthesia and Surgical Outcomes
- Tissue Engineering and Regenerative Medicine
- Electrospun Nanofibers in Biomedical Applications
- Aortic aneurysm repair treatments
- Mechanical Circulatory Support Devices
- Coronary Interventions and Diagnostics
- Cardiac Arrhythmias and Treatments
- Cardiac Ischemia and Reperfusion
- Congenital Heart Disease Studies
- Cardiovascular Effects of Exercise
- Cardiac tumors and thrombi
- Cardiovascular Function and Risk Factors
- Infectious Aortic and Vascular Conditions
- Atrial Fibrillation Management and Outcomes
- Cardiac electrophysiology and arrhythmias
- Acute Myocardial Infarction Research
- Cerebrovascular and Carotid Artery Diseases
- Cardiac pacing and defibrillation studies
- Angiogenesis and VEGF in Cancer
- Cardiac Health and Mental Health
University of Milan
2016-2025
Centro Cardiologico Monzino
2016-2025
Istituti di Ricovero e Cura a Carattere Scientifico
2018-2022
European Institute of Oncology
2021
Ripamonti
2021
Policlinico S.Orsola-Malpighi
2021
University of Maryland, Baltimore
2014
University of Baltimore
2014
Mylan (South Africa)
2012
Società Italiana di Fisica
1955-1961
The authors investigated whether PCSK9 inhibition could represent a therapeutic strategy in calcific aortic valve stenosis (CAVS). A meta-analysis of 10 studies was performed to determine the impact R46L variant on CAVS, and found that CAVS less prevalent carriers this (odds ratio: 0.80 [95% confidence interval: 0.70 0.91]; p = 0.0011) compared with noncarriers. expression higher valves patients control patients. In human interstitials cells submitted pro-osteogenic medium, levels increased...
Aortic valve disease is often treated with bioprosthetic valves. An alternative treatment aortic neocuspidization which a relatively new reparative procedure whereby the three cusps are replaced patient pericardium or bovine tissues. Recent research indicates that blood flow disturbed, and turbulence effects have yet to be evaluated in either types patient-specific settings. The aim of this study better understand production aorta evaluate its on laminar turbulent wall shear stress. Four...
The ability of hexarelin, a recently synthesized hexapeptide with strong growth hormone (GH)-releasing activity, or GH itself to display protectant activity against postischemic ventricular dysfunction in senescent hearts was studied 24-month-old male rats. Heart preparations from control (saline-treated) rats, subjected moderate ischemia, showed at reperfusion: (a) low recovery left developed pressure (LVDP; 37% the preischemic values; 90 +/- 5.7 33.5 3.8 mm Hg; p < 0.01; n = 10) coupled...
Background The pericardial tissue is commonly used to produce bio-prosthetic cardiac valves and patches in surgery. procedures adopted prepare this consist treatment with aldehydes, which do not prevent post-graft calcification due incomplete xeno-antigens removal. adoption of fixative-free decellularization protocols has been therefore suggested overcome limitation. Although promising, the decellularized pericardium yet clinics, absence proofs indicating that cryopreservation can...
Background CD 34+ stem/progenitor cells are involved in vascular homeostasis and neovascularization of ischemic tissues. The number circulating stem is a predictive biomarker adverse cardiovascular outcomes diabetic patients. Here, we provide evidence that hyperglycemia can be "memorized" by the through epigenetic changes contribute to onset maintenance their dysfunction diabetes mellitus. Methods Results Cord-blood-derived exposed high glucose displayed increased reactive oxygen species...
Arrhythmogenic Cardiomyopathy (ACM) is characterized by the replacement of myocardium with fibrotic or fibro-fatty tissue and inflammatory infiltrates in heart. To date, while ACM adipogenesis a well-investigated differentiation program, ACM-related fibrosis remains scientific gap knowledge. In this study, we analyze process occurring during pathogenesis focusing on role cardiac mesenchymal stromal cells (C-MSC) as source myofibroblasts. We performed ex vivo studies plasma right ventricular...
Background: New-onset postoperative atrial fibrillation (POAF) is the most common complication after cardiac surgery, occurring approximately in one-third of patients. This study considered all-comer patients who underwent surgery to build a predictive model for POAF. Methods: A total 3467 (Center 1) consecutive were used as derivation cohort model. The POLARIS score was then derived proportionally from odds ratios obtained following multivariable logistic regression (MLR). Brier Score, area...
Background: Extensive surgical resection of the thoracic aorta in patients with type A aortic dissection (TAAD) is thought to reduce risk late wall degeneration and need for repeat operations. Objectives: We evaluated early outcomes after root replacement supracoronary ascending TAAD involving root. Design: Retrospective, multicenter cohort study. Methods: The root, that flap located at least one Valsava segments, were herein evaluated. In-hospital mortality, neurological complications,...
Objectives: To investigate the optimal duration of venoarterial extracorporeal membrane oxygenation (ECMO) for cardiogenic shock refractory to medical therapies after cardiac surgery and whether its prolonged use is justified. Data Sources: Previously published articles on postcardiotomy ECMO. Study Selection: Articles reporting early outcome ECMO in adult patients were identified through a systematic review literature. Extraction: prespecified patients’ characteristics, operative variables,...
Background Data on the prognostic impact of type A aortic dissection involving common carotid arteries (CCAs) are scarce. Methods status CCAs were available in 1106 patients who underwent surgery for acute DeBakey 1 recruited a retrospective, multicentre European registry, that is, ERTAAD. Postoperative neurological complications defined as ischaemic stroke, haemorrhagic stroke and/or global brain ischaemia. Results Patients without artery dissection, those with unilateral or bilateral CCA...
Patients with end‐stage renal disease (ESRD) and concomitant coronary artery (CAD) present unique challenges for revascularization. While bypass grafting (CABG) is recommended over percutaneous intervention in this population, the optimal surgical strategy remains controversial. This meta‐analysis provides an updated comparison of outcomes ESRD patients undergoing CABG either bilateral internal thoracic (BITA) or single (SITA) grafting. A total nine studies involving 911 were included. Our...
Currently we observe a gap between theory and practices of patient engagement. If both scholars health practitioners do agree on the urgency to realize engagement, no shared guidelines exist so far orient clinical practice. Despite supportive policy context, progress achieve greater engagement is patchy slow often concentrated at level regulation without dialoguing with from field as well patients families. Though individual clinicians, care teams organizations may be interested deeply...
Saphenous vein graft disease is a timely problem in coronary artery bypass grafting. Indeed, after exposure of the to arterial blood flow, progressive modification wall begins, due proliferation smooth muscle cells intima. As consequence, progressively occludes and this leads recurrent ischemia. In present study we employed novel ex vivo culture system assess biological effects arterial-like pressure on human saphenous structure physiology, compare results those achieved presence constant...
We investigated the presence of antibiotics in cryopreserved cardiovascular tissues and cryopreservation media, after tissue decontamination with antibiotic cocktails, impact residues on standard bank microbiological analyses. Sixteen were decontaminated bank-prepared cocktails by two different banks according to their operating procedures. Before decontamination, samples underwent analysis methods. Cryopreserved tested again without removal using a RESEP tube, thawing. Presence homogenates...
Rationale: Despite the preferred application of arterial conduits, greater saphenous vein (SV) remains indispensable for coronary bypass grafting (CABG), especially in multi-vessel artery disease (CAD). The objective present work was to address role mechanical forces activation maladaptive remodeling, a process determining progressive occlusion and recurrence ischemic heart disease. Methods: We employed custom bioreactor mimic shear wall mechanics human SV vascular conduits reproduce...
Abstract Background There is an ever-growing number of patients requiring aortic valve replacement (AVR). Limited data available on the long-term outcomes and structural integrity bioprosthetic valves in younger undergoing surgical AVR. Methods The INSPIRIS RESILIA Durability Registry (INDURE) a prospective, open-label, multicentre, international registry with follow-up 5 years to assess clinical than 60 who undergo AVR using valve. INDURE will be conducted across 20–22 sites Europe Canada...