A5102890954- Cardiac Arrhythmias and Treatments
- Cardiac electrophysiology and arrhythmias
- Cardiac pacing and defibrillation studies
- Advanced MRI Techniques and Applications
- Cardiac Imaging and Diagnostics
- Atrial Fibrillation Management and Outcomes
- Lipoproteins and Cardiovascular Health
- Cardiovascular Effects of Exercise
- Nitric Oxide and Endothelin Effects
- Cardiovascular Function and Risk Factors
- Cardiac Fibrosis and Remodeling
- Acute Myocardial Infarction Research
- Cardiomyopathy and Myosin Studies
- Peripheral Artery Disease Management
- Signaling Pathways in Disease
- Mitochondrial Function and Pathology
- Ion channel regulation and function
- Atherosclerosis and Cardiovascular Diseases
- Cardiac Health and Mental Health
- Ultrasound and Hyperthermia Applications
- Cardiac Ischemia and Reperfusion
- Peptidase Inhibition and Analysis
- Telemedicine and Telehealth Implementation
- Heart Rate Variability and Autonomic Control
- Renin-Angiotensin System Studies
Klinikum Brandenburg
2015-2025
Brandenburg University of Technology Cottbus-Senftenberg
2021-2025
Medizinische Hochschule Brandenburg Theodor Fontane
2021-2025
University of Potsdam
2022-2025
Brandenburg University of Applied Sciences
2016-2025
Universitätsklinikum Würzburg
2009-2019
University of Würzburg
2005-2016
Comprehensive Cancer Center Mainfranken
2013-2016
German Centre for Cardiovascular Research
2016
Centre National de la Recherche Scientifique
2010
Abstract Radiofrequency (RF)‐related heating of cardiac pacemaker leads is a serious concern in magnetic resonance imaging (MRI). Recent investigations suggest such to be strongly dependent on an implant's position within the surrounding medium, but this issue currently poorly understood. In study, phantom measurements RF‐induced electric currents inside lead were performed investigate impact device and configuration amount MRI‐related at tip. Seven hundred twenty position/lead path...
Objective Cardiac diseases are established risk factors for ischemic stroke incidence and severity. Conversely, there is increasing evidence that brain ischemia can cause cardiac dysfunction. The mechanisms underlying this neurogenic heart disease incompletely understood. Although it associated with arrhythmias, myocardial damage, elevated enzymes, plasma catecholamines in the acute phase, nothing known about delayed consequences of on cardiovascular function. Methods To determine long‐term...
We previously demonstrated that conditional overexpression of neuronal nitric oxide synthase (nNOS) inhibited L-type Ca2+ channels and decreased myocardial contractility. However, nNOS has multiple targets within the cardiac myocyte. now hypothesize is cardioprotective after ischemia/reperfusion because inhibition mitochondrial function a reduction in reactive oxygen species generation.Ischemia/reperfusion injury wild-type mice resulted accumulation mitochondria. Similarly, transgenic caused...
Two sons of a consanguineous marriage developed biventricular cardiomyopathy. One boy died severe heart failure at the age 6 years, other was transplanted because 10 years. In addition, focal palmoplantar keratoderma and woolly hair were apparent in both boys. As similar phenotypes have been described Naxos disease Carvajal syndrome, respectively, genes for plakoglobin (JUP) desmoplakin (DSP) screened mutations using direct genomic sequencing. A novel homozygous 2 bp deletion identified an...
Abstract Implanted medical devices such as cardiac pacemakers pose a potential hazard in magnetic resonance imaging. Electromagnetic fields have been shown to cause severe radio frequency‐induced tissue heating some cases. Imaging exclusion zones proposed an instrument reduce patient risk. The purpose of this study was further assess the impact imaging landmark on risk for unintended implant by measuring electric body phantom under several conditions at 1.5T. results show that global...
The recognition of microthrombi in the heart microcirculation has recently emerged from studies COVID-19 decedents. present study investigated ultrastructure coronary failure (HF) due to cardiomyopathies that are unrelated infection. In addition, we have role von Willebrand factor (VWF) and PECAM-1 microthrombus formation. We used electron microscopy investigate occurrence patients with HF dilated (DCM, n = 7), inflammatory (MYO, 6) ischemic (ICM, 7) cardiomyopathy 4 control patients. VWF...
Background and purpose: Our recent experiments demonstrated that the Sphingosine‐1‐phosphate (S1P) receptor agonist FTY720 (2‐amino‐2‐[2‐(4‐octylphenyl)ethyl]‐1,3‐propanediol hydrochloride) improves recovery of function after myocardial ischaemia–reperfusion ex vivo . Therefore, we tested hypothesis pharmacological post‐conditioning with reduces infarct size in Experimental approach: Myocardial ischaemia was induced Wistar rats by ligation left coronary artery for 45 min. (0.5 mg·kg −1 )...
Abstract There are serious concerns regarding safety when performing magnetic resonance imaging in patients with implanted conductive medical devices, such as cardiac pacemakers, and associated leads, severe incidents have occurred the past. In this study, several approaches for altering an implant's lead design were systematically developed evaluated to enhance of devices a environment. The individual impact each change on radiofrequency heating was then investigated functional prototypes...
Anxiety, depression, and reduced quality of life (QoL) are common in patients with implantable cardioverter-defibrillators (ICDs). Treatment options limited insufficiently defined. We evaluated the efficacy a web-based intervention (WBI) vs. usual care (UC) for improving psychosocial well-being ICD elevated distress.This multicentre, randomized controlled trial (RCT) enrolled 118 increased anxiety or depression [≥6 points on either subscale Hospital Anxiety Depression Scale (HADS)] QoL [≤16...
Abstract Aims It was recently demonstrated that the intracellular signalling phosphatase calcineurin is subject to cleavage by protease calpain, resulting in a truncated fragment strong inductor of myocardial hypertrophy. We now address question whether inhibition calpain function cardiomyocytes, and thereby prevention truncation, attenuates development Methods results generated transgenic mouse model with conditional cardiac calpastatin overexpression (CAST OE) compared their hypertrophic...
Participants with CAD (n = 723) had 12% higher mean relative levels of nHDLox compared those invasively excluded 502, P < 0.001). Patients presenting symptoms an ACS the highest values when elective cohort (median 1.35, IQR 0.97 to 1.85, In multivariate analysis adjusted for age, sex, body mass index, and hypertension, was a strong independent predictor (P 0.001) but not > 0.05). HDL antioxidant function is reduced in patients CAD. strongly associated ACS. German Clinical Trials Register...
Background: Angiotensin-converting-enzyme inhibitors (ACEI) and angiotensin II receptor blockers (ARB) are widely used as a first-line therapy for the treatment of cardiovascular disease. Here, ACEI modulate bradykinin (BDKRB1 BDKRB2) system NO-dependent endothelial function, thus determining health regenerative arteriogenesis. The current study aims at evaluating nitric oxide-dependent gene expression receptors in peripheral blood mononuclear cells (PBMC) from patients with or ARB...
Coronary artery disease (CAD) is the leading cause of death worldwide. Statins reduce morbidity and mortality CAD. Intake n-3 polyunsaturated fatty acid (n-3 PUFAs), particularly eicosapentaenoic (EPA), associated with reduced in patients Previous data indicate that a higher conversion precursor acids (FAs) to arachidonic (AA) increased CAD prevalence. Our study explored FA composition blood assess PUFA levels from without We analyzed samples 273 undergoing cardiac catheterization. Patients...
Background and aims In the non-metropolitan region of Brandenburg (Germany), which is characterized by high rates cardiovascular diseases underserved medical care, there a lack awareness regarding lipoprotein(a) [Lp(a)] as risk factor. addition, data from patients with atherosclerotic disease (ASCVD) in diverse regional backgrounds, including understudied cohort, various healthcare statuses remain insufficient. Methods this WalkByLab study, Lp(a) levels were monitored cohort ( n = 850)...
Background Exercise training increases high-density lipoprotein (HDL) cholesterol, but its effect on HDL function is unclear. In hypertensives, exercise improves endothelial dysfunction, which related to function. the present study, we assess for first time effects of different modalities two cell-free assays Design The study was conducted as a prospective randomized controlled trial in 75 hypertensive patients. Methods Patients were three groups: (a) handgrip isometric five times weekly;...
Background Microbiome has been linked to the pathogenesis of coronary artery disease (CAD) but data providing direct evidence for an association short-chain fatty acids (SCFA) with CAD are lacking. This study aimed evaluate role propionate, most important SCFA in patients CAD. Methods We performed a cross-sectional enrolling admitted invasive angiography two university hospitals Germany. Patients known or suspected and risk factors cardiovascular were prospectively recruited. Blood sampling...
Abstract Determining the MR compatibility of medical implants and devices is becoming increasingly relevant. In most cases, heating conductive due to radiefrequency (RF) excitation pulses measured by fluoroptic temperature sensors in relevant tests for approval. Another common method determine these effects thermometry using proton resonance frequency. This gives good results homogeneous phantoms. However many technical shortcomings such as susceptibility artifacts prohibit exact frequency...