A5046629853- Coronary Interventions and Diagnostics
- Acute Myocardial Infarction Research
- Cardiac Imaging and Diagnostics
- Antiplatelet Therapy and Cardiovascular Diseases
- Cardiac Valve Diseases and Treatments
- Cerebrovascular and Carotid Artery Diseases
- Venous Thromboembolism Diagnosis and Management
- Atrial Fibrillation Management and Outcomes
- Peripheral Artery Disease Management
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiovascular Function and Risk Factors
- Health Systems, Economic Evaluations, Quality of Life
- Cardiac pacing and defibrillation studies
- Lipoproteins and Cardiovascular Health
- Aortic aneurysm repair treatments
- Cardiac and Coronary Surgery Techniques
- Cardiac Structural Anomalies and Repair
- Cardiovascular Disease and Adiposity
- Heparin-Induced Thrombocytopenia and Thrombosis
- Heart Failure Treatment and Management
- Infective Endocarditis Diagnosis and Management
- Mechanical Circulatory Support Devices
- Cardiac Arrest and Resuscitation
- Cardiac electrophysiology and arrhythmias
- Vascular Procedures and Complications
Icahn School of Medicine at Mount Sinai
2016-2025
Cardiovascular Institute of the South
2015-2025
Mount Sinai Hospital
2020-2025
Cardiovascular Research Foundation
2015-2024
Columbia University Irving Medical Center
2014-2024
NewYork–Presbyterian Hospital
2014-2024
New York Hospital Queens
2014-2024
Mount Sinai Medical Center
2013-2024
University of Washington
2003-2024
Mount Sinai Hospital
2020-2024
Atherosclerotic plaques that lead to acute coronary syndromes often occur at sites of angiographically mild coronary-artery stenosis. Lesion-related risk factors for such events are poorly understood.In a prospective study, 697 patients with underwent three-vessel angiography and gray-scale radiofrequency intravascular ultrasonographic imaging after percutaneous intervention. Subsequent major adverse cardiovascular (death from cardiac causes, arrest, myocardial infarction, or...
Restenosis after coronary stenting necessitates repeated percutaneous or surgical revascularization procedures. The delivery of paclitaxel to the site vascular injury may reduce incidence neointimal hyperplasia and restenosis.At 73 U.S. centers, we enrolled 1314 patients who were receiving a stent in single, previously untreated coronary-artery stenosis (vessel diameter, 2.5 3.75 mm; lesion length, 10 28 mm) prospective, randomized, double-blind study. A total 652 randomly assigned receive...
Among patients with heart failure who have mitral regurgitation due to left ventricular dysfunction, the prognosis is poor. Transcatheter mitral-valve repair may improve their clinical outcomes.
The success of thrombolytic therapy for acute myocardial infarction is limited by bleeding complications, the impossibility reperfusing all occluded coronary arteries, recurrent ischemia, and relatively small number patients who are appropriate candidates this therapy. We hypothesized that these problems could be overcome use immediate percutaneous transluminal angioplasty (PTCA), without previous
Among patients with stable coronary disease and moderate or severe ischemia, whether clinical outcomes are better in those who receive an invasive intervention plus medical therapy than alone is uncertain.
Treatment with the direct thrombin inhibitor bivalirudin, as compared heparin plus glycoprotein IIb/IIIa inhibitors, results in similar suppression of ischemia while reducing hemorrhagic complications patients stable angina and non-ST-segment elevation acute coronary syndromes who are undergoing percutaneous intervention (PCI). The safety efficacy bivalirudin high-risk unknown.We randomly assigned 3602 ST-segment myocardial infarction presented within 12 hours after onset symptoms were...
In patients with stable CAD, PCI can be considered a valuable initial mode of revascularization in all objective large ischaemia the presence almost every lesion subset, only one exception: chronic total occlusions that cannot crossed. early studies, there was small survival advantage CABG surgery compared without stenting. The addition stents and newer adjunctive medications improved outcome for PCI. decision to recommend or will guided by technical improvements cardiology surgery, local...
The safety of drug-eluting stents has been called into question by recent reports increased stent thrombosis, myocardial infarction, and death. Such studies have inconclusive because their insufficient size, the use historical controls, a limited duration follow-up, lack access to original source data.We performed pooled analysis data from four double-blind trials in which 1748 patients were randomly assigned receive either sirolimus-eluting or bare-metal five 3513 paclitaxel-eluting stents;...
Current guidelines for patients with moderate- or high-risk acute coronary syndromes recommend an early invasive approach concomitant antithrombotic therapy, including aspirin, clopidogrel, unfractionated low-molecular-weight heparin, and glycoprotein IIb/IIIa inhibitors. We evaluated the role of thrombin-specific anticoagulation bivalirudin in such patients.We assigned 13,819 to one three regimens: heparin enoxaparin plus a inhibitor, alone. The primary end points were composite ischemia...
As compared with thrombolytic therapy, primary percutaneous transluminal coronary angioplasty (PTCA) in acute myocardial infarction reduces the rates of death, reinfarction, and stroke, but recurrent ischemia, restenosis, reocclusion infarct-related artery remain problematic. When used combination PTCA, stenting platelet glycoprotein IIb/IIIa inhibitors may further improve outcomes.
Background —The angiographic presentation of in-stent restenosis (ISR) may convey prognostic information on subsequent target vessel revascularizations (TLR). Methods and Results —We developed an classification ISR according to the geographic distribution intimal hyperplasia in reference implanted stent. Pattern I includes focal (≤10 mm length) lesions, pattern II is ISR>10 within stent, III extending outside IV totally occluded ISR. We classified a total 288 lesions 245 patients verified...
Coronary-stent implantation is frequently performed for treatment of acute myocardial infarction. However, few studies have compared stent with primary angioplasty alone.We designed a multicenter study to compare accompanied by heparin-coated Palmaz-Schatz stent. Patients infarction underwent emergency catheterization and angioplasty. Those vessels suitable stenting were randomly assigned undergo (452 patients) or alone (448 patients).The mean (+/-SD) minimal luminal diameter was larger...
Patients with obstructive left main coronary artery disease are usually treated coronary-artery bypass grafting (CABG). Randomized trials have suggested that drug-eluting stents may be an acceptable alternative to CABG in selected patients disease.
Previous studies have established the superiority of coronary everolimus-eluting stents over paclitaxel-eluting with respect to angiographic findings. However, these trials were not powered for in clinical end points.We randomly assigned 3687 patients at 66 U.S. sites receive or without routine follow-up angiography. The primary point was 1-year composite rate target-lesion failure (defined as cardiac death, target-vessel myocardial infarction, ischemia-driven...