A5063797430- Acute Myocardial Infarction Research
- Cardiac Imaging and Diagnostics
- Health Systems, Economic Evaluations, Quality of Life
- Cardiac Health and Mental Health
- Heart Failure Treatment and Management
- Antiplatelet Therapy and Cardiovascular Diseases
- Cardiac, Anesthesia and Surgical Outcomes
- Atrial Fibrillation Management and Outcomes
- Frailty in Older Adults
- Coronary Interventions and Diagnostics
- Venous Thromboembolism Diagnosis and Management
- Cardiovascular Function and Risk Factors
- Blood Pressure and Hypertension Studies
- Cardiac Valve Diseases and Treatments
- Lipoproteins and Cardiovascular Health
- Cardiovascular Health and Risk Factors
- Cardiac Arrest and Resuscitation
- Pharmaceutical Practices and Patient Outcomes
- Peripheral Artery Disease Management
- Cardiovascular Disease and Adiposity
- Erythropoietin and Anemia Treatment
- Nutrition and Health in Aging
- Heart Rate Variability and Autonomic Control
- Cardiac pacing and defibrillation studies
- Healthcare cost, quality, practices
Clinical Research Institute
2016-2025
Duke University
2015-2025
Brigham and Women's Hospital
2010-2024
Duke Medical Center
2015-2024
Harvard University
2011-2024
Duke University Health System
2022-2024
Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
2024
Moss Landing Marine Laboratories
2019-2023
Sigma Theta Tau International
2023
Cellmark Forensic Services
2022
Among patients with stable coronary disease and moderate or severe ischemia, whether clinical outcomes are better in those who receive an invasive intervention plus medical therapy than alone is uncertain.
Background— Treatments for non–ST-segment–elevation myocardial infarction (NSTEMI) reduce ischemic events but increase bleeding. Baseline prediction of bleeding risk can complement optimization NSTEMI care; however, existing models are not well suited this purpose. Methods and Results— We developed (n=71 277) validated (n=17 857) a model that identifies 8 independent baseline predictors in-hospital major among community-treated patients enrolled in the Can Rapid stratification Unstable...
Effective medical care assumes delivery of evidence-based medicines to appropriate patients with doses comparable those studied.To investigate dosing unfractionated heparin (UFH), low-molecular-weight (LMWH), and glycoprotein IIb/IIIa inhibitors, the association between major outcomes.A prospective observational analysis in 387 US academic nonacademic hospitals 30,136 from CRUSADE (Can Rapid Risk Stratification Unstable Angina Patients Suppress Adverse Outcomes With Early Implementation...
Background— Age is an important determinant of outcomes for patients with acute coronary syndromes. However, community practice reveals a disproportionately lower use cardiovascular medications and invasive treatment even among elderly who would stand to benefit. Limited trial data are available guide care older adults, which results in uncertainty about benefits risks, particularly newer or treatments the setting advanced age complex health status. Methods Results— Part II this American...
Background— Chronic kidney disease (CKD) is a risk factor for myocardial infarction (MI) and death. Our goal was to characterize the association between CKD severity short-term outcomes use of in-hospital evidence-based therapies among patients with ST-segment elevation MI (STEMI) non–ST-segment (NSTEMI). Methods Results— The study sample drawn from Acute Coronary Treatment Intervention Outcomes Network registry, nationwide STEMI (n=19 029) NSTEMI (n=30 462) patients. Estimated glomerular...
Background— Cardiac surgery risk scores perform poorly in elderly patients, part because they do not take into account frailty and disability which are critical determinants of health status with advanced age. There is an unmet need to combine established cardiac measures provide a more complete model for prediction patients undergoing surgery. Methods Results— This was prospective, multicenter cohort study (≥70 years) coronary artery bypass and/or valve the United States Canada. Four...
Clinical trials that have assessed the effect of revascularization in patients with stable coronary disease routinely excluded those advanced chronic kidney disease.
In the ISCHEMIA trial, an invasive strategy with angiographic assessment and revascularization did not reduce clinical events among patients stable ischemic heart disease moderate or severe ischemia. A secondary objective of trial was to assess angina-related health status these patients.
OBJECTIVES: To characterize physiological variation in hospitalized older adults with severe coronary artery disease (CAD) and evaluate the prevalence of frailty this sample, to determine whether single‐item performance measures are good indicators multidimensional frailty, estimate association between 6‐month mortality. DESIGN: Observational cohort study. SETTING: Inpatient hospital cardiology ward. PARTICIPANTS: Three hundred nine consecutive inpatients aged 70 admitted a service (n=309;...