Harmony R. Reynolds
A5044263870- Cardiac Imaging and Diagnostics
- Acute Myocardial Infarction Research
- Coronary Interventions and Diagnostics
- Cardiac Health and Mental Health
- Cardiovascular Issues in Pregnancy
- COVID-19 Clinical Research Studies
- Cardiovascular Function and Risk Factors
- Cardiac Structural Anomalies and Repair
- Health Systems, Economic Evaluations, Quality of Life
- Takotsubo Cardiomyopathy and Associated Phenomena
- Heart Failure Treatment and Management
- Cardiovascular Disease and Adiposity
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiovascular Health and Risk Factors
- Long-Term Effects of COVID-19
- Peripheral Artery Disease Management
- Atherosclerosis and Cardiovascular Diseases
- Mechanical Circulatory Support Devices
- Cardiac Valve Diseases and Treatments
- Antiplatelet Therapy and Cardiovascular Diseases
- Venous Thromboembolism Diagnosis and Management
- Blood Pressure and Hypertension Studies
- Sepsis Diagnosis and Treatment
- COVID-19 and healthcare impacts
- Cerebrovascular and Carotid Artery Diseases
New York University
2016-2025
NYU Langone Health
2013-2024
Phoenix Children's Hospital
2024
North Tees and Hartlepool NHS Foundation Trust
2024
Association Clinique et Thérapeutique Infantile du Val de Marne
2023
Saint Luke's Hospital
2023
Oxfam
2023
Liechtenstein Institute
2023
John Wiley & Sons (United States)
2023
Hudson Institute
2023
Among patients with stable coronary disease and moderate or severe ischemia, whether clinical outcomes are better in those who receive an invasive intervention plus medical therapy than alone is uncertain.
There is concern about the potential of an increased risk related to medications that act on renin-angiotensin-aldosterone system in patients exposed coronavirus disease 2019 (Covid-19), because viral receptor angiotensin-converting enzyme 2 (ACE2).We assessed relation between previous treatment with ACE inhibitors, angiotensin-receptor blockers, beta-blockers, calcium-channel or thiazide diuretics and likelihood a positive negative result Covid-19 testing as well severe illness (defined...
Thrombosis and inflammation may contribute to morbidity mortality among patients with coronavirus disease 2019 (Covid-19). We hypothesized that therapeutic-dose anticoagulation would improve outcomes in critically ill Covid-19.
ST-Segment Elevation in Covid-19 Eighteen patients with presented ST-segment elevation on ECG or had it develop during hospitalization. Eight received a diagnosis of acute my...
The management of acute myocardial infarction (AMI)1 has evolved over the past century and particularly in 50 years. Important milestones include development electrocardiogram, coronary care units, angiography, reperfusion therapies, troponin assays. These innovations are foundation contemporary AMI strategies that a diagnosis centred on elevated values associated with corroborative clinical evidence,1 early use therapies.2–4 Pivotal evolution these were angiography studies undertaken by...
It is unclear whether stable, high-risk patients with persistent total occlusion of the infarct-related coronary artery identified after currently accepted period for myocardial salvage has passed should undergo percutaneous intervention (PCI) in addition to receiving optimal medical therapy reduce risk subsequent events.We conducted a randomized study involving 2166 stable who had 3 28 days infarction and met criterion (an ejection fraction <50% or proximal occlusion). Of these patients,...
Thrombosis and inflammation may contribute to the risk of death complications among patients with coronavirus disease 2019 (Covid-19). We hypothesized that therapeutic-dose anticoagulation improve outcomes in noncritically ill who are hospitalized Covid-19.In this open-label, adaptive, multiplatform, controlled trial, we randomly assigned were Covid-19 not critically (which was defined as an absence critical care-level organ support at enrollment) receive pragmatically regimens either...
There is increasing recognition of a prothrombotic state in COVID-19. Post-mortem examination can provide important mechanistic insights.
Background— There is no angiographically demonstrable obstructive coronary artery disease (CAD) in a significant minority of patients with myocardial infarction, particularly women. We sought to determine the mechanism(s) infarction this setting using multiple imaging techniques. Methods and Results— Women were enrolled prospectively, before angiography, if possible. ≥50% angiographic stenosis or use vasospastic agents excluded. Intravascular ultrasound was performed during angiography;...
Abstract Background Ambient air pollution is a modifiable risk factor for cardiovascular disease, yet uncertainty remains about the size of risks at lower levels fine particulate matter (PM2.5) exposure which now occur in USA and elsewhere. Methods We investigated relationship ambient PM2.5 with cause-specific disease mortality 565 477 men women, aged 50 to 71 years, from National Institutes Health-AARP Diet Health Study. During 7.5 x 106 person-years follow up, 41 286 deaths, including 23...
Clinical trials that have assessed the effect of revascularization in patients with stable coronary disease routinely excluded those advanced chronic kidney disease.
In the ISCHEMIA trial, an invasive strategy with angiographic assessment and revascularization did not reduce clinical events among patients stable ischemic heart disease moderate or severe ischemia. A secondary objective of trial was to assess angina-related health status these patients.
Background We compared the clinical characteristics and outcomes of young patients with myocardial infarction nonobstructive coronary arteries ( MINOCA ) versus obstructive disease (myocardial due to artery [ MI ‐ CAD ]) among by sex subtype. Methods Results Between 2008 2012, VIRGO (Variation in Recovery: Role Gender on Outcomes Young AMI Patients) prospectively enrolled acute aged 18 55 years 103 hospitals at a 2:1 ratio women men. Using an angiographically driven taxonomy, we defined as...
<h3>Importance</h3> Black and Hispanic populations have higher rates of coronavirus disease 2019 (COVID-19) hospitalization mortality than White but lower in-hospital case-fatality rates. The extent to which neighborhood characteristics comorbidity explain these disparities is unclear. Outcomes in Asian American not been explored. <h3>Objective</h3> To compare COVID-19 outcomes based on race ethnicity assess the association any with characteristics. <h3>Design, Setting, Participants</h3>...
Background— Sex differences in early mortality after myocardial infarction (MI) vary by age. MI with nonobstructive coronary arteries (MINOCA [<50% stenosis]) is more common among younger patients and women, MINOCA has a better prognosis than obstructive artery disease (MI-CAD). The relationship between age, sex, CAD status outcomes post-MI not been established. Methods Results— Adults who underwent angiography for acute ST-segment–elevation non–ST-segment–elevation the National...
Myocardial infarction with nonobstructive coronary arteries (MINOCA) occurs in 6% to 15% of myocardial infarctions (MIs) and disproportionately affects women. Scientific statements recommend multimodality imaging MINOCA define the underlying cause. We performed optical coherence tomography (OCT) cardiac magnetic resonance (CMR) assess mechanisms MINOCA.
Background:Outdoor fine particulate matter (≤ 2.5 μm; PM2.5) has been identified as a global health threat, but the number of large U.S. prospective cohort studies with individual participant data remains limited, especially at lower recent exposures.Objectives:We aimed to test relationship between long-term exposure PM2.5 and death risk from all nonaccidental causes, cardiovascular (CVD), respiratory diseases in 517,041 men women enrolled National Institutes Health-AARP...
The ISCHEMIA trial (International Study of Comparative Health Effectiveness With Medical and Invasive Approaches) postulated that patients with stable coronary artery disease (CAD) moderate or severe ischemia would benefit from revascularization. We investigated the relationship between severity CAD outcomes, overall by management strategy. In total, 5179 were randomized to an initial invasive conservative Blinded, core laboratory-interpreted computed tomographic angiography was used assess...