A5080300349- Occupational Health and Performance
- Injury Epidemiology and Prevention
- Melanoma and MAPK Pathways
- Air Quality and Health Impacts
- Cancer Immunotherapy and Biomarkers
- Dementia and Cognitive Impairment Research
- Immunotherapy and Immune Responses
- Cutaneous Melanoma Detection and Management
- Statistical Methods and Inference
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Statistical Methods in Clinical Trials
- Cancer Genomics and Diagnostics
- Advanced Statistical Methods and Models
- Genetic Associations and Epidemiology
- Health Systems, Economic Evaluations, Quality of Life
- Climate Change and Health Impacts
- Bayesian Methods and Mixture Models
- Statistical Methods and Bayesian Inference
- Statistical Distribution Estimation and Applications
- MicroRNA in disease regulation
- Optimal Experimental Design Methods
- Glioma Diagnosis and Treatment
- Genetic Mapping and Diversity in Plants and Animals
- Brain Metastases and Treatment
- Occupational and environmental lung diseases
New York University
2016-2025
Chinese University of Hong Kong, Shenzhen
2025
NYU Langone Health
2013-2024
Bellevue Hospital Center
2012-2024
Health Center
2017-2022
New York City Health and Hospitals Corporation
2020-2022
University School
2013-2021
Thomas Jefferson University Hospital
2020
Eastern Virginia Medical School
2020
Population Council
2019
Abstract Background Ambient air pollution is a modifiable risk factor for cardiovascular disease, yet uncertainty remains about the size of risks at lower levels fine particulate matter (PM2.5) exposure which now occur in USA and elsewhere. Methods We investigated relationship ambient PM2.5 with cause-specific disease mortality 565 477 men women, aged 50 to 71 years, from National Institutes Health-AARP Diet Health Study. During 7.5 x 106 person-years follow up, 41 286 deaths, including 23...
T cells expressing antigen-specific T-cell receptors (TCRs) can mediate effective tumor regression, but they often also are accompanied by autoimmune responses. To determine the TCR affinity threshold defining optimal balance between antitumor activity and autoimmunity in vivo , we used a unique self-antigen system comprising seven human melanoma gp100(209–217)-specific TCRs spanning physiological affinities (1–100 μM). We found that vitro responses determined affinity, except one case was...
Background:Outdoor fine particulate matter (≤ 2.5 μm; PM2.5) has been identified as a global health threat, but the number of large U.S. prospective cohort studies with individual participant data remains limited, especially at lower recent exposures.Objectives:We aimed to test relationship between long-term exposure PM2.5 and death risk from all nonaccidental causes, cardiovascular (CVD), respiratory diseases in 517,041 men women enrolled National Institutes Health-AARP...
Rationale: Many studies have linked short-term exposure to ozone (O3) with morbidity and mortality, but epidemiologic evidence of associations between long-term O3 mortality is more limited.Objectives: To investigate (annual or warm season average daily 8-h maximum concentrations) all-cause cause-specific in the NIH-AARP Diet Health Study, a large prospective cohort U.S. adults 17 years follow-up from 1995 2011.Methods: The (n = 548,780) was census tract–level estimates for O3. Associations...
Abstract T cell-mediated immunity to microbes and cancer can be enhanced by the activation of dendritic cells (DCs) via TLRs. In this study, we evaluated safety feasibility topical imiquimod, a TLR7 agonist, in series vaccinations against cancer/testis Ag NY-ESO-1 patients with malignant melanoma. Recombinant, full-length protein was administered intradermally into imiquimod preconditioned sites followed additional applications imiquimod. The regimen very well tolerated only mild transient...
Abstract Purpose: High-grade glioma treatment includes ionizing radiation therapy. The high invasiveness of cells precludes their eradication and is responsible for the dismal prognosis. Recently, we reported down-regulation MHC class I (MHC-I) products in invading tumor human mouse GL261 gliomas. Here, tested hypothesis that whole-brain radiotherapy (WBRT) up-regulates MHC-I expression on tumors enhances effectiveness immunotherapy. Experimental Design: molecule was analyzed vitro vivo by...
Abstract Drug resistance significantly limits the long-term effectiveness of targeted therapeutics for cancer patients. Recent experimental studies have demonstrated that cell heterogeneity and microenvironment adaptations to therapy play important roles in promoting rapid acquisition drug increasing metastasis. The systematic development effective overcome mechanisms poses a major challenge. In this study, we used modeling approach connect cellular underlying population-level patient...
Background: Recent experimental evidence suggests that nutritional supplementation can blunt adverse cardiopulmonary effects induced by acute air pollution exposure. However, whether usual individual dietary patterns modify the association between long-term exposure and health outcomes has not been previously investigated. We assessed, in a large cohort with detailed diet information at level, Mediterranean modifies to ambient cardiovascular disease mortality risk. Methods: The National...
Abstract Background Identification of melanoma patients at high risk for recurrence and monitoring are critical informed management decisions. We hypothesized that serum microRNAs (miRNAs) could provide prognostic information the time diagnosis unaccounted by current staging system be useful in detecting after resection. Methods screened 355 miRNAs sera from 80 primary (discovery cohort) using a unique quantitative reverse transcription-PCR (qRT-PCR) panel. Cox proportional hazard models...
This paper describes the large sample properties of likelihood ratio test statistic (LRTS) when parameters characterizing true null distribution are not unique. It is well known that classical asymptotic theory for does apply to such problems and LRTS may have typical chi-squared type limiting distribution. establishes a general quadratic approximation log-likelihood function in Hellinger neighborhood density which valid with or without loss identifiability Under suitable conditions, under...
Brain metastasis is the major cause of mortality among patients with melanoma. A molecular prognostic test that can reliably stratify at initial melanoma diagnosis by risk developing brain may inform clinical management these patients.We performed a retrospective, cohort-based study analyzing genome-wide and targeted microRNA expression profiling primary tumors three patient cohorts (n = 92, 119, 45) extensive follow-up. We used Cox regression analysis to establish microRNA-based signature...
Background: Although 20% to 30% of melanomas are histopathologically 'nevus associated,' the majority arise de novo, ie, in clinically normal skin with no associated nevus. We examined whether these forms melanoma differed their associations clinical and histopathologic features patient survival. Methods: analyzed two prospective cohorts from our institution protocol-driven follow-up information (NYU1, n = 1024; NYU2, 1125). used univariate multivariable analyses examine between novo vs...
Melanoma lacks a clinically useful blood‐based biomarker of disease activity to help guide patient management. To determine whether measurements circulating, cell‐free, tumor‐associated BRAFmutant and NRASmutant DNA (ctDNA) have higher sensitivity than LDH detect metastatic prior treatment initiation upon progression we studied patients with unresectable stage IIIC/IV melanoma receiving BRAF inhibitor therapy or immune checkpoint blockade at least 3 plasma samples obtained during their...
Systemic inflammation has emerged as a promising marker and potential mechanism underlying post-traumatic stress disorder (PTSD). The relationship between posttraumatic pathology systemic not, however, been consistently replicated is potentially confounded by comorbid illness or injury, common complications of trauma exposure. We analyzed large naturalistic cohort sharing discrete physical mental health from the destruction World Trade Center (WTC) towers on September 11, 2001 (n = 641)....
This paper investigates a new test for normality that is easy biomedical researchers to understand and implement in all dimensions. In terms of power comparison against broad range alternatives, the outperforms best known competitors literature as demonstrated by simulation results. addition, proposed illustrated using data from real studies.
Several reports have demonstrated a role for aberrant NOTCH signaling in melanoma genesis and progression, prompting us to explore if targeting this pathway is valid therapeutic approach against melanoma. We targeted using RO4929097, novel inhibitor of gamma secretase, which key component the enzymatic complex that cleaves activates NOTCH. The effects RO4929097 on oncogenic stem cell properties panel lines were tested both vitro vivo, xenograft models. In human primary lines, decreased...
The tumor-associated microenvironment plays important roles in tumor progression and drug resistance. However, systematic investigations of macrophage-tumor cell interactions to identify novel macrophage-related gene signatures gliomas for predicting patient prognoses responses targeted therapies are lacking.We developed a multicellular network approach investigating the prognostic role resistance gliomas. Multicellular networks connecting macrophages cells were constructed from re-grouped...