A5026490128- Cutaneous Melanoma Detection and Management
- Melanoma and MAPK Pathways
- Immunotherapy and Immune Responses
- Cancer Genomics and Diagnostics
- Cancer Immunotherapy and Biomarkers
- Advances in Oncology and Radiotherapy
- Gastric Cancer Management and Outcomes
- CAR-T cell therapy research
- Pancreatic and Hepatic Oncology Research
- Innovations in Medical Education
- MicroRNA in disease regulation
- Diversity and Career in Medicine
- Global Health and Surgery
- Sarcoma Diagnosis and Treatment
- Cardiac, Anesthesia and Surgical Outcomes
- Brain Metastases and Treatment
- Nonmelanoma Skin Cancer Studies
- Cell Adhesion Molecules Research
- Neuroendocrine Tumor Research Advances
- Cell Image Analysis Techniques
- AI in cancer detection
- Protein Degradation and Inhibitors
- vaccines and immunoinformatics approaches
- Circular RNAs in diseases
- melanin and skin pigmentation
NYU Langone Health
2014-2024
New York University
2015-2024
Weill Cornell Medicine
2024
Cornell University
1981-2024
Eastern Cooperative Oncology Group
2013-2023
Hinge Health
2018-2023
Bellevue Hospital Center
2004-2022
New York City Health and Hospitals Corporation
2020
Twitter (United States)
2020
VA NY Harbor Healthcare System
2015-2019
Although remission rates for metastatic melanoma are generally very poor, some patients can survive prolonged periods following metastasis. We used gene expression profiling, mitotic index (MI), and quantification of tumor infiltrating leukocytes (TILs) CD3+ cells in lesions to search a molecular basis this observation develop improved methods predicting patient survival. identified group 266 genes associated with postrecurrence Genes positively survival were predominantly immune response...
The rationale for using small molecule inhibitors of oncogenic proteins as cancer therapies depends, at least in part, on the assumption that metastatic tumors are primarily clonal with respect to mutant oncogene. With emergence BRAFV600E a therapeutic target, we investigated intra- and inter-tumor heterogeneity melanoma detection mutation marker clonality. BRAF mutant-specific PCR (MS-PCR) conventional sequencing were performed 112 from 73 patients, including patients matched primary...
Abstract T cell-mediated immunity to microbes and cancer can be enhanced by the activation of dendritic cells (DCs) via TLRs. In this study, we evaluated safety feasibility topical imiquimod, a TLR7 agonist, in series vaccinations against cancer/testis Ag NY-ESO-1 patients with malignant melanoma. Recombinant, full-length protein was administered intradermally into imiquimod preconditioned sites followed additional applications imiquimod. The regimen very well tolerated only mild transient...
To identify a melanoma microRNA (miRNA) expression signature that is predictive of outcome and then evaluate its potential to improve risk stratification when added the standard-of-care staging criteria.Total RNA was extracted from 59 formalin-fixed paraffin-embedded metastases hybridized miRNA arrays containing 911 probes. We correlated with post-recurrence survival other clinicopathologic criteria.We identified 18 miRNAs whose overexpression significantly longer survival, defined as more...
Abstract Background Identification of melanoma patients at high risk for recurrence and monitoring are critical informed management decisions. We hypothesized that serum microRNAs (miRNAs) could provide prognostic information the time diagnosis unaccounted by current staging system be useful in detecting after resection. Methods screened 355 miRNAs sera from 80 primary (discovery cohort) using a unique quantitative reverse transcription-PCR (qRT-PCR) panel. Cox proportional hazard models...
Melanoma is one of ten most common cancers in the US. Early detection crucial for survival, but often cancer diagnosed fatal stage. Deep learning has potential to improve rates, its applicability melanoma compromised by limitations available skin lesion data bases, which are small, heavily imbalanced, and contain images with occlusions. We build deep-learning-based tools purification augmentation counter-act these limitations. The developed can be utilized a deep system classification we...
Abstract Background Two primary histologic subtypes, superficial spreading melanoma (SSM) and nodular (NM), comprise the majority of all cutaneous melanomas. NM is associated with worse outcomes, which have been attributed to increased thickness at presentation, it widely expected that SSM would exhibit similar behavior once metastasized. Herein, we tested hypothesis subtype an independent predictor survival may impact response treatment in metastatic setting. Methods We examined most recent...
Melanoma patients who develop brain metastases (B-Met) have limited survival and are excluded from most clinical trials. In the current study, authors attempted to identify primary tumor characteristics features predictive of B-Met development post-B-Met survival.A prospectively accrued cohort 900 melanoma was studied clinicopathologic (eg, thickness, ulceration, mitotic index, lymphovascular invasion) that after a diagnosis B-Met. Associations between variables present at time extracranial...
Brain metastasis is the major cause of mortality among patients with melanoma. A molecular prognostic test that can reliably stratify at initial melanoma diagnosis by risk developing brain may inform clinical management these patients.We performed a retrospective, cohort-based study analyzing genome-wide and targeted microRNA expression profiling primary tumors three patient cohorts (n = 92, 119, 45) extensive follow-up. We used Cox regression analysis to establish microRNA-based signature...
Objective: To describe and evaluate trends of general surgery residency applicants, matriculants, graduates over the last 13 years. Summary Background Data: The application matriculation rates URMs to medical school has remained unchanged three decades with Blacks Hispanics representing 7.1% 6.3% respectively. With each succession along surgical career pathway, from a faculty position, percentage decreases. Methods: Electronic Residency Application Service General Surgery Graduate Medical...
For patients with sentinel lymph node (SLN)-positive cutaneous melanoma, the Second Multicenter Selective Lymphadenectomy trial demonstrated equivalent disease-specific survival (DSS) active surveillance using nodal ultrasound versus completion dissection (CLND). Adoption and outcomes of in clinical practice adjuvant therapy recipients are unknown.In a retrospective cohort SLN-positive adults treated at 21 institutions Australia, Europe, United States from June 2017 to November 2019, authors...
<h3>Importance</h3> The lack of underrepresented in medicine physicians within US academic surgery continues, with Black surgeons representing a disproportionately low number. <h3>Objective</h3> To evaluate the trend general residency application, matriculation, and graduation rates for trainees compared their racial ethnic counterparts over time. <h3>Design, Setting, Participants</h3> In this nationwide multicenter study, data from Electronic Residency Application Service (ERAS) match...
In patients with T1b-T3b cutaneous melanoma the utility of radiologic imaging at time diagnosis is unclear. Whether initial led to a change in stage or treatment plan was investigated.The database searched for primary lesions, clinically N0, and asymptomatic metastatic disease. Radiologic studies conducted before wide local excision +/- sentinel lymph node biopsy as well all further investigations were analyzed. Outcome measures included upstaging, surgical management, true-positive,...
Late infection of devitalized pancreatic and peripancreatic tissue has become the major cause morbidity in severe acute pancreatitis. Previous experience found that peritoneal lavage for periods 48 to 96 hours may reduce early systemic complications but did not decrease late sepsis. A fortunate observation led present study influence a longer period on Twenty-nine patients receiving primary nonoperative treatment pancreatitis (three or more positive prognostic signs) were randomly assigned...
Nodular melanoma (NM) may be biologically aggressive compared with the more common superficial spreading (SSM), recent data suggesting underlying genetic differences between these 2 subtypes. To better define clinical behavior of NMs, authors their and histopathologic features to those SSMs at institution, a tertiary referral center, over 3 decades.A total 1,684 patients diagnosed 1,734 melanomas were prospectively enrolled. Of these, 1,143 (69% SSM, 11% NM, 20% other) 1972 1982; 541 (54%...