Dusan Bogunovic
A5065646905- interferon and immune responses
- Immunodeficiency and Autoimmune Disorders
- Immune Cell Function and Interaction
- SARS-CoV-2 and COVID-19 Research
- Cytokine Signaling Pathways and Interactions
- Immunotherapy and Immune Responses
- Inflammasome and immune disorders
- Cancer Immunotherapy and Biomarkers
- Immune Response and Inflammation
- Systemic Lupus Erythematosus Research
- Kawasaki Disease and Coronary Complications
- CAR-T cell therapy research
- Diabetes and associated disorders
- Down syndrome and intellectual disability research
- T-cell and B-cell Immunology
- COVID-19 Clinical Research Studies
- Respiratory viral infections research
- IL-33, ST2, and ILC Pathways
- Atherosclerosis and Cardiovascular Diseases
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Melanoma and MAPK Pathways
- COVID-19 Impact on Reproduction
- Cell Image Analysis Techniques
- Cell Adhesion Molecules Research
- Single-cell and spatial transcriptomics
Columbia University Irving Medical Center
2024-2025
Hiroshima University
2024-2025
Columbia University
2024-2025
Icahn School of Medicine at Mount Sinai
2015-2024
Child Health and Development Institute
2016-2023
Mount Sinai Health System
2022
SUNY Upstate Medical University
2021
Rockefeller University
2010-2015
New York University
2007-2013
NYU Langone Health
2009-2011
The highly aggressive character of melanoma makes it an excellent model for probing the mechanisms underlying metastasis, which remains one most difficult challenges in treating cancer. We find that miR-182, member a miRNA cluster chromosomal locus (7q31-34) frequently amplified melanoma, is commonly up-regulated human cell lines and tissue samples; this up-regulation correlates with gene copy number subset lines. Moreover, miR-182 ectopic expression stimulates migration cells vitro their...
Tuberculosis Vaccine Conundrum Some children experience severe clinical disease when they are vaccinated against tuberculosis, an attenuated live vaccine that is normally innocuous in humans. Several germline mutations have been identified account for this susceptibility, and now Bogunovic et al. (p. 1684 , published online 2 August) add another to the list— ISG15 . Uncovering mutation, which inherited autosomal recessive manner, was a surprise because studies with mice deficient showed...
Although remission rates for metastatic melanoma are generally very poor, some patients can survive prolonged periods following metastasis. We used gene expression profiling, mitotic index (MI), and quantification of tumor infiltrating leukocytes (TILs) CD3+ cells in lesions to search a molecular basis this observation develop improved methods predicting patient survival. identified group 266 genes associated with postrecurrence Genes positively survival were predominantly immune response...
Autosomal recessive, complete TYK2 deficiency was previously described in a patient (P1) with intracellular bacterial and viral infections features of hyper-IgE syndrome (HIES), including atopic dermatitis, high serum IgE levels, staphylococcal abscesses. We identified seven other TYK2-deficient patients from five families four different ethnic groups. These were homozygous for one null mutations, that seen P1. They displayed mycobacterial and/or infections, but no HIES. All eight impaired...
Pseudo-TORCH syndrome (PTS) is characterized by microcephaly, enlarged ventricles, cerebral calcification, and, occasionally, systemic features at birth resembling the sequelae of congenital infection but in absence an infectious agent. Genetic defects resulting activation type 1 interferon (IFN) responses have been documented to cause Aicardi-Goutières syndrome, which a PTS. Ubiquitin-specific peptidase 18 (USP18) key negative regulator I IFN signaling. In this study, we identified...
Abstract ISG15 is an interferon (IFN)-α/β-induced ubiquitin-like protein. It exists as a free molecule, intracellularly and extracellularly, conjugated to target proteins. Studies in mice have demonstrated role for Isg15 antiviral immunity. By contrast, human was shown critical immune functions, but not Namely, extracellular crucial IFN-γ-dependent antimycobacterial immunity, while intracellular USP18-mediated downregulation of IFN-α/β signalling. Here we describe -deficient patients who...
Recessive or dominant inborn errors of type I interferon (IFN) immunity can underlie critical COVID-19 pneumonia in unvaccinated adults. The risk children, which is much lower than adults, remains unexplained. In an international cohort 112 children (<16 yr old) hospitalized for pneumonia, we report 12 (10.7%) aged 1.5–13 with (7 children), severe (3), and moderate (2) 4 the 15 known clinically recessive biochemically complete IFN immunity: X-linked TLR7 deficiency children) autosomal...
Autoantibodies neutralizing type I interferons (IFNs) can underlie critical COVID-19 pneumonia and yellow fever vaccine disease. We report here on 13 patients harboring autoantibodies IFN-α2 alone (five patients) or with IFN-ω (eight from a cohort of 279 (4.7%) aged 6–73 yr influenza pneumonia. Nine four had antibodies high low concentrations, respectively, IFN-α2, six two IFN-ω. The patients’ increased A virus replication in both A549 cells reconstituted human airway epithelia. prevalence...
Cytokines employ downstream Janus kinases (JAKs) to promote chronic inflammatory diseases. JAK1-dependent type 2 cytokines drive allergic inflammation, and patients with JAK1 gain-of-function (GoF) variants develop atopic dermatitis (AD) asthma. To explore tissue-specific functions, we inserted a human GoF variant (JAK1GoF) into mice observed the development of spontaneous AD-like skin disease but unexpected resistance lung inflammation when JAK1GoF expression was restricted stroma. We...
We have previously shown that mouse atherosclerosis regression involves monocyte-derived (CD68+) cell emigration from plaques and is dependent on the chemokine receptor CCR7. Concurrent with regression, mRNA levels of gene encoding LXRalpha are increased in plaque CD68+ cells, suggestive a functional relationship between LXR To extend these results, atherosclerotic Apoe-/- mice sufficient or deficient CCR7 were treated an agonist, resulting CCR7-dependent decrease cells. test requirement for...