Lana A. Castellucci
A5045012686- Venous Thromboembolism Diagnosis and Management
- Atrial Fibrillation Management and Outcomes
- Blood Coagulation and Thrombosis Mechanisms
- Acute Ischemic Stroke Management
- COVID-19 Clinical Research Studies
- Sepsis Diagnosis and Treatment
- Antiplatelet Therapy and Cardiovascular Diseases
- Long-Term Effects of COVID-19
- Heparin-Induced Thrombocytopenia and Thrombosis
- Intracerebral and Subarachnoid Hemorrhage Research
- Central Venous Catheters and Hemodialysis
- Intramuscular injections and effects
- Platelet Disorders and Treatments
- Social Media in Health Education
- Blood Pressure and Hypertension Studies
- Cerebral Venous Sinus Thrombosis
- COVID-19 and healthcare impacts
- Case Reports on Hematomas
- Cardiac Arrhythmias and Treatments
- Health Systems, Economic Evaluations, Quality of Life
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Respiratory Support and Mechanisms
- Pharmaceutical industry and healthcare
- Patient-Provider Communication in Healthcare
- Acute Myocardial Infarction Research
Ottawa Hospital
2016-2025
University of Ottawa
2016-2025
Ottawa Hospital Research Institute
2014-2025
ORCID
2025
Azienda Ospedaliero-Universitaria di Modena
2023
University Health Network
2021
St. Michael's Hospital
2021
Health Sciences Centre
2021
Sunnybrook Health Science Centre
2021
St. Boniface Hospital
2021
Thrombosis and inflammation may contribute to morbidity mortality among patients with coronavirus disease 2019 (Covid-19). We hypothesized that therapeutic-dose anticoagulation would improve outcomes in critically ill Covid-19.
Thrombosis and inflammation may contribute to the risk of death complications among patients with coronavirus disease 2019 (Covid-19). We hypothesized that therapeutic-dose anticoagulation improve outcomes in noncritically ill who are hospitalized Covid-19.In this open-label, adaptive, multiplatform, controlled trial, we randomly assigned were Covid-19 not critically (which was defined as an absence critical care-level organ support at enrollment) receive pragmatically regimens either...
To evaluate the effects of therapeutic heparin compared with prophylactic among moderately ill patients covid-19 admitted to hospital wards.
Importance Randomized clinical trials (RCTs) of therapeutic-dose heparin in patients hospitalized with COVID-19 produced conflicting results, possibly due to heterogeneity treatment effect (HTE) across individuals. Better understanding HTE could facilitate individualized decision-making. Objective To evaluate for and compare approaches assessing HTE. Design, Setting, Participants Exploratory analysis a multiplatform adaptive RCT vs usual care pharmacologic thromboprophylaxis 3320 enrolled...
Spontaneous intracerebral hemorrhage is a particularly devastating type of stroke with greater morbidity and mortality compared ischemic can account for half or more all deaths from stroke. The seventh update the Canadian Stroke Best Practice Recommendations includes new stand-alone module on hemorrhage, focus elements care that are unique affect persons disproportionately relative to Prior this edition, was included in Acute Management limited its management during first 12 h. With growing...
To assess the effectiveness of prone positioning to reduce risk death or respiratory failure in non-critically ill patients admitted hospital with covid-19.Multicentre pragmatic randomised clinical trial.15 hospitals Canada and United States from May 2020 until 2021.Eligible had a laboratory confirmed clinically highly suspected diagnosis covid-19, needed supplemental oxygen (up 50% fraction inspired oxygen), were able independently lie verbal instruction. Of 570 who assessed for...
Background: It is uncertain if medical masks offer similar protection against COVID-19 compared with N95 respirators. Objective: To determine whether are noninferior to respirators prevent in health care workers providing routine care. Design: Multicenter, randomized, noninferiority trial. (ClinicalTrials.gov: NCT04296643). Setting: 29 facilities Canada, Israel, Pakistan, and Egypt from 4 May 2020 March 2022. Participants: 1009 who provided direct patients suspected or confirmed COVID-19....
Pulmonary embolism (PE) has not been accounted for as a cause of death contributing to cause-specific mortality in global reports.We analyzed PE-related by focusing on the latest year available each member state World Health Organization (WHO) database, which provides age-sex-specific aggregated data transmitted national authorities underlying death. deaths were defined International Classification Diseases, Tenth Revision codes acute PE or nonfatal manifestations venous thromboembolism...
Background: The incidence of pulmonary embolism has been increasing, but its case-fatality rate is decreasing, suggesting a lesser severity illness. clinical importance patients with isolated to the subsegmental vessels unknown. Objective: To determine recurrent venous thromboembolism in managed without anticoagulation. Design: Multicenter prospective cohort study. (ClinicalTrials.gov: NCT01455818) Setting: Eighteen sites between February 2011 and 2021. Patients: Patients embolism....
Abstract Background Heparin, in addition to its anticoagulant properties, has anti-inflammatory and potential anti-viral effects, may improve endothelial function patients with Covid-19. Early initiation of therapeutic heparin could decrease the thrombo-inflammatory process, reduce risk critical illness or death. Methods We randomly assigned moderately ill hospitalized ward admitted for Covid-19 elevated D-dimer level prophylactic heparin. The primary outcome was a composite death, invasive...