A5070574032- Venous Thromboembolism Diagnosis and Management
- Atrial Fibrillation Management and Outcomes
- Blood Coagulation and Thrombosis Mechanisms
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Acute Lymphoblastic Leukemia research
- Eosinophilic Disorders and Syndromes
- Central Venous Catheters and Hemodialysis
- Cardiac Arrhythmias and Treatments
- COVID-19 Clinical Research Studies
- Acute Ischemic Stroke Management
- Antiplatelet Therapy and Cardiovascular Diseases
- Hemoglobinopathies and Related Disorders
- Platelet Disorders and Treatments
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Liver Disease and Transplantation
- Blood properties and coagulation
- Childhood Cancer Survivors' Quality of Life
- Protease and Inhibitor Mechanisms
- Heparin-Induced Thrombocytopenia and Thrombosis
- Erythrocyte Function and Pathophysiology
- Cerebral Venous Sinus Thrombosis
- Pregnancy and preeclampsia studies
- Chronic Myeloid Leukemia Treatments
- Diabetes Treatment and Management
- Multiple Myeloma Research and Treatments
Erasmus MC
2020-2025
Erasmus University Rotterdam
2020-2025
Population Health Research Institute
2014-2023
Amsterdam University Medical Centers
2020-2021
University of Amsterdam
2010-2021
Amsterdam Neuroscience
2020
Amsterdam UMC Location University of Amsterdam
2010-2019
University of North Carolina at Chapel Hill
2019
Hamilton Health Sciences
2014-2017
McMaster University
2014
AimsThe pattern of atrial fibrillation (AF) occurrence—paroxysmal, persistent, or permanent—is associated with progressive stages dysfunction and structural changes may therefore be progressively higher stroke risk. However, previous studies have not consistently shown AF to predict but been hampered by methodological shortcomings low power, variable event ascertainment, anticoagulant use.
Objective— The formation of neutrophil extracellular traps and the exposure nucleosomes on these contribute to coagulation activation propagation deep vein thrombosis (DVT) in animal models. However, no data are available role or patients with thrombosis. Methods Results— We conducted a case–control study, which levels circulating elastase–α1-antitrypsin complexes were assessed plasma from 150 objectified symptomatic DVT (cases) compared 195 clinical suspicion but whom was excluded...
Objective The prevalence of atrial fibrillation (AF) and the risk stroke bleeding vary according to age. To estimate effects dabigatran, compared with warfarin, on stroke, mortality in patients AF Randomized Evaluation Long-Term Anticoagulant Therapy (RE-LY) trial age, we analysed treatment using age as a continuous variable categories. Methods RE-LY included 10 855 (59.9%) aged <75 years, 4231 (23.4%) 75–79 2305 (12.7%) 80–84 years 722 (4.0%) ≥85 at baseline. Results Benefits dabigatran...
Venous thromboembolism (VTE) is relatively common in children with acute lymphoblastic leukemia (ALL). Thrombotic risk factors ALL are asparaginase and steroids. However, within the populations treated on same regimen, it less clear which other play a role. Furthermore, few data available effect of VTE outcomes.In 778 (1-18 years) newly diagnosed precursor-B-lineage or T-lineage ALL, Dutch Childhood Oncology Group (DCOG) ALL-10 protocol Netherlands (October 2004 to April 2013), we conducted...
Background and Aims: Since the introduction of SARS-CoV-2 vaccines, several cases vaccine-induced immune thrombocytopenia thrombosis (VITT) have been described, especially cerebral vein thrombosis. We aimed to retrospectively collect all new acute onset first or recurrent splanchnic (SVT) following a recent vaccination within Vascular Liver Disease Group network. Approach Results: New SVT were identified from April 2021 2022; follow-up was completed on December 31, 2022. Criteria define VITT...
Glucagon-like peptide 1 receptor agonists (GLP1-RA) are anti-diabetes agents recently approved for weight loss. Obesity is an established risk factor venous thromboembolism (VTE). Moreover, preclinical studies have shown that GLP1-RA may attenuate thromboxaneinduced platelet activation. Therefore, we hypothesized use reduce the of VTE. We performed a target trial emulation using population-based database electronic health records to evaluate whether associated with reduction in VTE patients...
Pyruvate kinase (PK) is a key enzyme involved in the final step of glycolysis, essential to produce adenosine triphosphate (ATP). Relatively decreased red blood cell (RBC) PK activity (reflected by lower PK/hexokinase [HK] ratio) and thermostability (PK after exposure heat) were recently identified as pathophysiological features sickle disease (SCD). In this study, we investigated whether impaired function associated with RBC properties SCD-related clinical manifestations. This study...
Summary Treatment of acute lymphoblastic leukaemia (ALL) is frequently complicated by venous thromboembolism (VTE). The efficacy and optimal approach VTE prevention are unclear, particularly in adult patients. We assessed the effect thromboprophylaxis on symptomatic incidence cycle 1 ALL treatment Secondly, we explored potential etiologic factors for clinical impact outcome. retrospectively use 240 adults treated newly diagnosed Dutch-Belgian HOVON-37 multicentre study (1999–2005). Potential...
Venous thromboembolism (VTE) is a common and severe complication during treatment of acute lymphoblastic leukemia (ALL). An important cause the intensive use asparaginase. Prospective cohort studies in which prophylactic low-molecular-weight heparin (LMWH) was used to prevent VTE showed lower risk than historic control cohorts, with negligible bleeding risk. However, efficacy thromboprophylaxis LMWH ALL has never been investigated randomized design. Here, we present protocol controlled trial...
Thrombosis is a frequent and severe complication in patients with coronavirus disease 2019 (COVID-19) admitted to the intensive care unit (ICU). Lupus anticoagulant (LA) strong acquired risk factor for thrombosis various diseases frequently observed COVID-19. Whether LA associated COVID-19 currently unclear.To investigate if critically ill COVID-19.The presence of other antiphospholipid antibodies was assessed ICU. determined dilute Russell's viper venom time (dRVVT) LA-sensitive activated...