A5008013552- Venous Thromboembolism Diagnosis and Management
- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- Acute Myocardial Infarction Research
- Atrial Fibrillation Management and Outcomes
- Antiplatelet Therapy and Cardiovascular Diseases
- Cancer-related molecular mechanisms research
- Central Venous Catheters and Hemodialysis
- COVID-19 and healthcare impacts
- Acute Ischemic Stroke Management
- Radiomics and Machine Learning in Medical Imaging
- Cardiac tumors and thrombi
- Ferroptosis and cancer prognosis
- Renal cell carcinoma treatment
- Prenatal Screening and Diagnostics
- Glioma Diagnosis and Treatment
- Blood groups and transfusion
- Blood Coagulation and Thrombosis Mechanisms
- Dermatological and COVID-19 studies
- Radiation Dose and Imaging
- Inflammatory Biomarkers in Disease Prognosis
- Hemoglobinopathies and Related Disorders
- Lipoproteins and Cardiovascular Health
- Thermal Regulation in Medicine
- Ultrasound in Clinical Applications
Leiden University Medical Center
2020-2025
Medical University of Vienna
2023
Leiden University
2022
University of Curaçao
2021
University Medical Center Groningen
2021
University of Groningen
2021
IntroductionIn the first wave, thrombotic complications were common in COVID-19 patients. It is unknown whether state-of-the-art treatment has resulted less second wave.MethodsWe assessed incidence of and overall mortality patients admitted to eight Dutch hospitals between September 1st November 30th 2020. Follow-up ended at discharge, transfer another hospital, when they died, or on 2020, whichever came first. Cumulative incidences estimated, adjusted for competing risk death. These...
Whereas accumulating studies on patients with coronavirus disease 2019 (COVID-19) report high incidences of thrombotic complications, large clinically relevant thrombosis in other respiratory tract infections are lacking. How this risk COVID-19 compares to those observed hospitalized viral pneumonias such as influenza is unknown.To assess the incidence venous and arterial complications opposed that COVID-19.This was a retrospective cohort study; we used data from Statistics Netherlands...
Renal cell carcinoma (RCC) can be complicated by a venous tumor thrombus (TT), of which the optimal management is unknown.This study sought to assess prevalence TT in RCC, its current management, and association with thromboembolism (VTE), arterial (ATE), major bleeding (MB), mortality.Patients diagnosed RCC between 2010 2019 our hospital were included followed from diagnosis until 2 years after, or an outcome interest (VTE, ATE, MB) death occurred, depending on analysis. Cumulative...
Glioblastoma patients are considered to be at high risk of venous thromboembolism (VTE) and major bleeding (MB), although reliable incidence estimates lacking. Moreover, the arterial (ATE) in these is largely unknown. Our aim was assess cumulative incidence, predictors, prognostic impact VTE, ATE, MB on subsequent complications mortality.Cohort study 967 consecutive diagnosed with glioblastoma between 2004-2020 two hospitals. Patients were followed from 6 months before date histopathological...
Thrombosis is a frequent and severe complication in patients with coronavirus disease 2019 (COVID-19) admitted to the intensive care unit (ICU). Lupus anticoagulant (LA) strong acquired risk factor for thrombosis various diseases frequently observed COVID-19. Whether LA associated COVID-19 currently unclear.To investigate if critically ill COVID-19.The presence of other antiphospholipid antibodies was assessed ICU. determined dilute Russell's viper venom time (dRVVT) LA-sensitive activated...
Patients with glioblastoma have a high risk of developing venous thromboembolism (VTE). However, the role underlying genetic factors remains largely unknown. Therefore, aim this study was to discover whether aberrations in associate VTE risk.In cohort study, all consecutive patients diagnosed two Dutch hospitals between February 2017 and August 2020 were included. Targeted DNA next-generation sequencing glioblastomas performed for diagnostic purposes included mutational status genes ATRX,...
In the recent years, numerous studies on optimal treatment and prevention of cancer-associated venous thromboembolism (VTE) have been published, leading to updated (inter)national guidelines. These include direct oral anticoagulants (DOACs) as first-line agent in general recommendation primary thromboprophylaxis selected ambulatory patients.The objective this study was evaluate clinical practice regarding VTE patients with cancer Netherlands variation among different specialties.An online...
It is unclear how often cancer patients with acute pulmonary embolism (PE) are discharged from the emergency department (ED) or outpatient clinic and whether direct discharge safe. We assessed treatment setting early safety outcomes in symptomatic incidental PE.
Abstract Background Diagnostic strategies for suspected pulmonary embolism (PE) have not been prospectively evaluated in COVID-19 patients. Methods Prospective, multicenter, outcome study 707 patients with both (suspected) and PE 14 hospitals. Patients on chronic anticoagulant therapy were excluded. Informed consent was obtained by opt-out approach. managed validated diagnostic PE. We the safety (3-month failure rate) efficiency (number of computed tomography angiographies [CTPAs] avoided)...
Patients with osteosarcoma (OS) and Ewing sarcoma (ES) are considered to have a high venous thromboembolism (VTE) risk, although the exact incidence prognostic impact under-researched in general as well relevant age groups.To study of VTE major bleeding (MB) OS ES patients, subdivided children, Adolescents Young Adults (AYAs; aged 18-39) older adults.Retrospective single-center chart review 519 165 patients treated between 1980 2018. were followed from diagnosis until an outcome interest...
Significance Statement Hypertension and elevated levels of LDL cholesterol (LDLc) are vital risk factors for cardiovascular disease (CVD) in patients with CKD. Although statins indisputably reduce plasma levels, not all renal benefit from them, making CVD the leading cause CKD-related mortality. CKD induces hyperelongation hepatic heparan sulfate (HS) chains HS proteoglycans (HSPG), thereby increasing HSPG–proprotein convertase subtilisin kexin type-9 (PCSK9) interaction. These changes...
Abstract Background Whereas accumulating studies on COVID-19 patients report high incidences of thrombotic complications, large clinically relevant thrombosis in with other respiratory tract infections are lacking. How this risk compares to those observed hospitalized viral pneumonias such as influenza is unknown. Objectives To assess the incidence venous and arterial complications opposed that patients. Methods Retrospective cohort study; we used data from Statistics Netherlands (study...
Background: It is unclear how often cancer patients with acute symptomatic or incidental pulmonary embolism (PE) are discharged from the emergency department (ED), what determinants of discharge are, and whether ED safe in this setting.Aims: To assess treatment setting (hospitalization vs ED), potential for ED, safety outcomes ambulatory PE.Methods: Cancer diagnosed PE between August 2017 May 2021 were included a Dutch multicenter retrospective cohort study.The primary hospitalization.Safety...
Abstract Background Current guidelines recommend either low-molecular weight heparin (LMWH) or direct oral anticoagulants (DOACs) as first-line treatment in cancer-associated venous thromboembolism (VTE). Aim This study aimed to investigate regimens for VTE over the past 5 years, explore predictors initial (LMWH vs. DOAC), and assess risks of recurrent bleeding. Methods was a Dutch, multicenter, retrospective cohort including consecutive patients with between 2017 2021. Treatment were...
Abstract BACKGROUND Patients with glioblastoma have a high risk of developing venous thromboembolism (VTE). However, the underlying genetic factors remain largely unknown. Therefore, aim our study was to discover whether aberrations in associate VTE. MATERIAL AND METHODS In this retrospective cohort study, all patients diagnosed between February 2017 and August 2020 two hospitals (Leiden University Medical Center Haaglanden Center) were included (n=341). Targeted DNA next-generation...
Abstract BACKGROUND Patients with glioblastoma are considered to be at high risk of venous thromboembolism (VTE) and major bleeding (MB), although reliable incidence estimates lacking. The aim this study was assess the cumulative incidence, factors prognostic impact VTE MB in a large cohort patients. MATERIAL AND METHODS diagnosed between 2004–2020 from Leiden University Medical Center Haaglanden were included followed 6 months before date histopathological diagnosis up two years after, or...