A5026053362- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- Antifungal resistance and susceptibility
- Fungal Infections and Studies
- Respiratory Support and Mechanisms
- SARS-CoV-2 and COVID-19 Research
- Mechanical Circulatory Support Devices
- Cardiac and Coronary Surgery Techniques
- Antimicrobial Resistance in Staphylococcus
- Sepsis Diagnosis and Treatment
- Cardiac Valve Diseases and Treatments
- Cardiac, Anesthesia and Surgical Outcomes
- Pneumonia and Respiratory Infections
- Viral Infections and Vectors
- COVID-19 Impact on Reproduction
- Pneumocystis jirovecii pneumonia detection and treatment
- Electroconvulsive Therapy Studies
- Viral Infections and Outbreaks Research
- Cardiac Arrest and Resuscitation
- Potassium and Related Disorders
- Takotsubo Cardiomyopathy and Associated Phenomena
- Venous Thromboembolism Diagnosis and Management
- Intracranial Aneurysms: Treatment and Complications
- Adrenal and Paraganglionic Tumors
- Vasculitis and related conditions
Leiden University Medical Center
2013-2024
Leiden University
2021
Rijnland Ziekenhuis
2005
Triazole resistance is an increasing problem in invasive aspergillosis (IA). Small case series show mortality rates of 50%–100% patients infected with a triazole-resistant Aspergillus fumigatus, but direct comparison triazole-susceptible IA lacking. A 5-year retrospective cohort study (2011–2015) was conducted to compare voriconazole-susceptible and voriconazole-resistant IA. fumigatus culture-positive were investigated identify proven, probable, putative Clinical characteristics, day 42 90...
The prevalence of invasive aspergillosis (IA) at the intensive care unit (ICU) is unknown and difficult to assess since IA also develops in patients lacking specific host factors. In Netherlands, increasing azole-resistance Aspergillus fumigatus complicates treatment with IA. aim this study was determine by azole-resistant A. ICU among receiving antifungal follow their clinical outcome prognosis. A retrospective cohort conducted a university hospital from January 2010 December 2013. From all...
COVID-19 associated pulmonary aspergillosis (CAPA) is with increased morbidity and mortality in ICU patients. We investigated the incidence of, risk factors for potential benefit of a pre-emptive screening strategy CAPA ICUs Netherlands/Belgium during immunosuppressive treatment.A retrospective, observational, multicentre study was performed from September 2020-April 2021 including patients admitted to who had undergone diagnostics CAPA. Patients were classified based on 2020 ECMM/ISHAM...
A high prevalence of COVID-19 associated pulmonary aspergillosis (CAPA) has been reported, though histopathological evidence is frequently lacking. To assess the clinical significance Aspergillus species in respiratory samples mechanically ventilated patients, we implemented routine screening for tracheal aspirate (TA).
The diagnostic performance of a prospective, systematic screening strategy for COVID-19 associated pulmonary aspergillosis (CAPA) during the pandemic was investigated. Patients with admitted to ICU were screened CAPA twice weekly by collection tracheal aspirate (TA) Aspergillus culture and PCR. Subsequently, bronchoalveolar lavage (BAL) sampling performed in patients positive results clinical suspicion infection. Patient data collected from April 2020-February 2022. classified according 2020...
In the randomized controlled trial REMAP-CAP, it was shown that next to dexamethasone, interleukin (IL)-6 receptor antagonist tocilizumab improves outcome, including survival in intensive care unit (ICU)-admitted coronavirus disease 2019 (COVID)-19 patients. Therefore has been added many COVID-19 treatment guidelines. Because obesity is a risk factor for development of severe COVID-19, concerns have raised about overtreatment, as well undertreatment, through weight-based dosing tocilizumab....
The goal of the study was to describe population pharmacokinetics trimethoprim, sulfamethoxazole, and N ‐acetyl sulfamethoxazole in hospitalized patients. Furthermore, this used model optimize dosing regimens cotrimoxazole for Pneumocystis jirovecii pneumonia patients with renal insufficiency or continuous replacement therapy (CRRT). This a retrospective multicenter observational cohort based on therapeutic drug monitoring (TDM) data from treated cotrimoxazole. We developed two...
Instrumental variable methods can potentially circumvent the unmeasured confounding inherent in observational data analyses.We investigated validity and usefulness of physician's preference instrumental analysis setting a moderate-sized clinical study. Using routine care from 476 elective cardiac surgery patients, we assessed effect preoperative corticosteroids on mechanical ventilation time duration intensive hospital stay, occurrence infections, atrial fibrillation, heart failure,...
Aim: Biomarkers of acute respiratory distress syndrome (ARDS) after cardiac-surgery may help risk-stratification and management. Preoperative single-value proADM increases predictive capacity scoring-system EuroSCORE. To include the impact surgery, we aim to assess value perioperative proADM-change on development ARDS in 40 patients. Materials & methods: ProADM was measured nine sequential blood samples. The Berlin definition used. For data-analyses, a multivariate model EuroSCORE...