A5080888126- Clinical Nutrition and Gastroenterology
- Renal function and acid-base balance
- Electrolyte and hormonal disorders
- Nitric Oxide and Endothelin Effects
- Antifungal resistance and susceptibility
- Nutrition and Health in Aging
- Intensive Care Unit Cognitive Disorders
- Eicosanoids and Hypertension Pharmacology
- Muscle and Compartmental Disorders
- Organ Transplantation Techniques and Outcomes
- Liver Disease and Transplantation
- Fungal Infections and Studies
- Abdominal Surgery and Complications
- Family and Patient Care in Intensive Care Units
- Sepsis Diagnosis and Treatment
- Pneumonia and Respiratory Infections
- Anesthesia and Sedative Agents
- Poisoning and overdose treatments
- Cardiac, Anesthesia and Surgical Outcomes
- Mechanical Circulatory Support Devices
- Esophageal and GI Pathology
- Cardiac Ischemia and Reperfusion
- COVID-19 Clinical Research Studies
- Diet and metabolism studies
- Blood transfusion and management
Erasmus University Rotterdam
2004-2024
Erasmus MC
2009-2023
Intensive Care Foundation
2010-2011
Vrije Universiteit Amsterdam
2000-2004
Amsterdam UMC Location Vrije Universiteit Amsterdam
2003
University of Amsterdam
1998-2001
St Clara Hospital
1988-1993
Rotterdam University of Applied Sciences
1992
GGz centraal
1992
Delirium is often unrecognized in ICU patients and associated with poor outcome. Screening for delirium recommended by several medical organizations to improve early diagnosis treatment. The Confusion Assessment Method the (CAM-ICU) has high sensitivity specificity when administered research nurses. However, test characteristics of CAM-ICU as performed routine practice are unclear.To investigate diagnostic value daily practice.Teams three experts including psychiatrists, geriatricians,...
Triazole resistance is an increasing problem in invasive aspergillosis (IA). Small case series show mortality rates of 50%–100% patients infected with a triazole-resistant Aspergillus fumigatus, but direct comparison triazole-susceptible IA lacking. A 5-year retrospective cohort study (2011–2015) was conducted to compare voriconazole-susceptible and voriconazole-resistant IA. fumigatus culture-positive were investigated identify proven, probable, putative Clinical characteristics, day 42 90...
Background. Mycograb (NeuTec Pharma) is a human recombinant monoclonal antibody against heat shock protein 90 that, in laboratory studies, was revealed to have synergy with amphotericin B broad spectrum of Candida species.
Introduction Loss-of-function TLR7 variants have been recently reported in a small number of males to underlie strong predisposition severe COVID-19. We aimed determine the presence these rare young men with Methods prospectively studied between 18 and 50 years-old without predisposing comorbidities that required at least high-flow nasal oxygen treat The coding region was sequenced assess potentially deleterious variants. Results missense were identified two out 14 patients (14.3%). Overall,...
Lactic acid was first found and described in sour milk by Karl Wilhelm Scheele (1742–1786) 1780. The German physician–chemist Johann Joseph Scherer (1841–1869) demonstrated the occurrence of lactic human blood under pathological conditions 1843 1851. In this article we honour forgotten observations describe influence Scherer's finding on further research at end 19th century. We conclude that case reports should be cited as description after death also demonstration a septic haemorrhagic...
A considerable number of patients admitted to the intensive care unit (ICU) die following withdrawal mechanical ventilation. After discontinuation ventilation without proper preparation, excessive respiratory secretion is common, resulting in a 'death rattle'. Post-extubation stridor can give rise relatives' perception that patient choking and suffering. Existing protocols lack adequate anticipatory preparation respond all distressing symptoms.We analyzed existing treatment strategies...
Background: Hyperlactatemia and its reduction after admission in the intensive care unit (ICU) have been related to survival. Because it is unknown whether this equally applies different groups of critically ill patients, we compared prognostic value repeated lactate levels (a) septic patients versus with hemorrhage or other conditions generally associated low-oxygen transport (LT) (b) hemodynamically stable unstable patients. Methods: In prospective observational two-center study (n = 394...
Rhabdomyolysis, if severe, can lead to acute kidney injury (AKI). Myoglobin is an iron and oxygen-binding protein that freely filtered by the glomerulus. Precipitation of myoglobin in nephrons’ distal parts responsible for tubular damage with AKI as a consequence. Extracorporeal clearance conventionally attempted use continuous renal replacement therapy (CRRT) high cut-off dialysis membranes limit extent damage. We describe case 56-year-old man traumatic crush persistent source muscle...
Background & aimsDifferent metabolic phases can be distinguished in critical illness, which influences nutritional treatment. Achieving optimal treatment during these critically ill patients is challenging. COVID-19 seem particularly difficult to feed due gastrointestinal problems. Our aim was describe measured resting energy expenditure (mREE) and feeding practices tolerance the acute late of illness patients.MethodsObservational study including mechanically ventilated adult patients....
Asymmetric dimethylarginine (ADMA) has been recognized as an endogenous inhibitor of the arginine-nitric oxide (NO) pathway. Its concentration is tightly regulated by urinary excretion and degradation enzyme dimethylaminohydrolase (DDAH), which highly expressed in liver. Considering liver a crucial organ clearing ADMA, we hypothesized increased ADMA levels during hepatic failure and, consequently, decline concentrations after successful transplantation. The aim present study was to...
Studies on head injury-induced pituitary dysfunction are limited in number and conflicting results have been reported.To further clarify this issue, 29 consecutive patients (24 males), with severe (n = 21) or moderate 8) trauma, having a mean age of 37 ± 17 years were investigated the immediate post-trauma period.All required mechanical ventilatory support for 8-55 days enrolled study within few before ICU discharge.Basal hormonal assessment included measurement cortisol, corticotropin, free...
<i>Background/Aims:</i> Placental dysfunction of the asymmetric dimethylarginine (ADMA) degrading enzyme dimethylaminohydrolase (DDAH) has been suggested as one initiating events in development preeclampsia (PE). Our primary aim was to investigate role placenta metabolism ADMA during normal pregnancy and PE. <i>Methods:</i> We studied 27 nonpregnant healthy women (C), 15 normotensive pregnant females (P), 16 patients with PE, 7 ‘hemolysis, elevated liver enzymes low...
Asymmetric dimethylarginine (ADMA) is an endogenous inhibitor of the arginine-nitric oxide pathway. It conceivable that its concentration tightly regulated by urinary excretion and degradation enzyme dimethylaminohydrolase, which highly expressed in liver. In rats, we showed a high net hepatic uptake ADMA. Therefore, aimed to confirm role liver humans hypothesized elevated ADMA levels after major resection reduction functional mass injury remnant liver.Patients undergoing (HEP, n = 17) or...
The use of indirect calorimetry to determine energy requirements is highly recommended in critically ill patients. To facilitate this a new and easy calorimeter (Q-NRG+, Cosmed) was developed. primary aim our study describe the usefulness and, secondarily, investigate agreement between measured predicted needs large cohort adult