A5009497429- Antifungal resistance and susceptibility
- Fungal Infections and Studies
- Infectious Diseases and Mycology
- Nematode management and characterization studies
- Ocular Infections and Treatments
- Bacterial biofilms and quorum sensing
- Pneumonia and Respiratory Infections
- Pneumocystis jirovecii pneumonia detection and treatment
- Plant Pathogens and Fungal Diseases
- Medical and Biological Ozone Research
Radboud University Nijmegen
2015-2020
Radboud University Medical Center
2015-2020
Canisius-Wilhelmina Ziekenhuis
2015-2020
Leiden University Medical Center
2020
University of Groningen
2020
VieCuri Medisch Centrum
2017-2020
National Institute for Public Health and the Environment
2020
Amsterdam University Medical Centers
2020
University Medical Center Groningen
2020
Vrije Universiteit Amsterdam
2020
Triazole resistance is an increasing problem in invasive aspergillosis (IA). Small case series show mortality rates of 50%–100% patients infected with a triazole-resistant Aspergillus fumigatus, but direct comparison triazole-susceptible IA lacking. A 5-year retrospective cohort study (2011–2015) was conducted to compare voriconazole-susceptible and voriconazole-resistant IA. fumigatus culture-positive were investigated identify proven, probable, putative Clinical characteristics, day 42 90...
Increasing resistance of Aspergillus fumigatus to triazoles in high-risk populations is a concern. Its impact on mortality not well understood, but rates from 50% 100% have been reported.To determine the prevalence voriconazole-resistant A. invasive aspergillosis (IA) and its associated large multicentre cohort haematology patients with culture-positive IA.We performed retrospective study, which outcomes proven/probable IA were analysed. Patients stratified based voriconazole susceptibility...
We investigated the prevalence of azole resistance Aspergillus fumigatus isolates in Netherlands by screening clinical A. for during 2013-2018. analyzed azole-resistant phenotypically vitro susceptibility testing and presence mutations Cyp51A gene. Over 6-year period, 508 (11%) 4,496 culture-positive patients harbored an isolate. Resistance frequency increased from 7.6% (95% CI 5.9%-9.8%) 2013 (58/760 patients) to 14.7% 12.3%-17.4%) 2018 (112/764 (p = 0.0001). TR34/L98H (69%)...
A survey of diagnosis and treatment invasive aspergillosis was conducted in eight University Medical Centers (UMCs) non-academic teaching hospitals the Netherlands. Against a background emerging azole resistance Aspergillus fumigatus routine screening clinical isolates performed primarily UMCs. Azole rates at hospital level varied between 5% 10%, although up to 30% were reported high-risk wards. Voriconazole remained first choice for 13 out 16 hospitals. In documented 14 centres treated...
To investigate the epidemiology and clinical relevance of triazole resistance among patients undergoing treatment for haematological malignancies who are at risk invasive aspergillosis (IA).This was a retrospective cohort study which records consecutive given chemotherapy AML or myelodysplastic syndrome (MDS) had received an allogeneic HSCT from 2006 to 2012 were reviewed IA. Triazole detected by VIPcheck™ screening method confirmed determining MIC EUCAST methodology.A total 432 included,...