A5016225042- Antibiotic Resistance in Bacteria
- Bacterial Identification and Susceptibility Testing
- Antibiotic Use and Resistance
- HIV/AIDS drug development and treatment
- Antimicrobial Resistance in Staphylococcus
- Urinary Tract Infections Management
- HIV/AIDS Research and Interventions
- Neutropenia and Cancer Infections
- Pneumonia and Respiratory Infections
- HIV Research and Treatment
- Pharmaceutical and Antibiotic Environmental Impacts
- Antibiotics Pharmacokinetics and Efficacy
- Mycobacterium research and diagnosis
- HIV-related health complications and treatments
- Escherichia coli research studies
- Pneumocystis jirovecii pneumonia detection and treatment
- Enterobacteriaceae and Cronobacter Research
- Streptococcal Infections and Treatments
- Gut microbiota and health
- Nosocomial Infections in ICU
- Patient Satisfaction in Healthcare
- Evolution and Genetic Dynamics
- Clostridium difficile and Clostridium perfringens research
- Antifungal resistance and susceptibility
- Social Media in Health Education
National Institute for Public Health and the Environment
2017-2025
National Centre for Infectious Diseases
2023
Radboud University Nijmegen
2020
University of Groningen
2020
Amsterdam University Medical Centers
2020
Vrije Universiteit Amsterdam
2020
Radboud University Medical Center
2020
Canisius-Wilhelmina Ziekenhuis
2020
Leiden University Medical Center
2020
University Medical Center Groningen
2020
In the Netherlands, number of cases infection with New Delhi metallo-beta-lactamase (NDM)-positive Enterobacteriaceae is low. Here, we report an outbreak NDM-1-producing Klebsiella pneumoniae in a Dutch hospital interspecies transfer resistance plasmid and unexpected occurrence other unrelated health care centers (HCCs). Next-generation sequencing was performed on 250 carbapenemase-producing isolates, including 42 NDM-positive isolates obtained from 29 persons at site. Most were K. (n = 26)...
We investigated the prevalence of azole resistance Aspergillus fumigatus isolates in Netherlands by screening clinical A. for during 2013-2018. analyzed azole-resistant phenotypically vitro susceptibility testing and presence mutations Cyp51A gene. Over 6-year period, 508 (11%) 4,496 culture-positive patients harbored an isolate. Resistance frequency increased from 7.6% (95% CI 5.9%-9.8%) 2013 (58/760 patients) to 14.7% 12.3%-17.4%) 2018 (112/764 (p = 0.0001). TR34/L98H (69%)...
Since March 2022, there has been an emergence of multidrug-resistant organisms (MDRO) in the Netherlands patients originating from Ukraine (58 patients, 75 isolates). For about half these recent hospitalisation was reported. Genomic surveillance revealed that majority MDRO represent globally spread epidemic lineages and 60% contain New Delhi metallo-β-lactamase (NDM) genes. Professionals should be aware increase such associated with migration medical evacuation people Ukraine.
Abstract Introduction : The number of HIV‐infected children and adolescents requiring second‐line antiretroviral treatment (ART) is increasing in low‐ middle‐income countries (LMIC). However, the effectiveness paediatric ART potential risk factors for virologic failure are poorly characterized. We performed an aggregate analysis outcomes assessed need third‐line ART. Methods a multicentre by systematically reviewing literature to identify cohorts receiving LMIC, contacting corresponding...
Abstract Background The Netherlands is currently considered a low endemic country for carbapenem-resistant Enterobacterales (CRE) and carbapenemase-producing (CPE), experiencing only sporadic hospital outbreaks. This study aims to describe susceptibility carbapenems the epidemiology of carbapenemase production in 2017–2019. Methods Three complementary nationwide surveillance systems are place monitor carbapenem Netherlands. Routine antimicrobial test results from medical microbiology...
This study aims to describe the virological, immunological and clinical efficacy of protease inhibitor (PI)-based second-line antiretroviral therapy (ART) in rural South Africa.An observational cohort was performed on 210 patients (including 39 children) who initiated PI-based at least 12 months prior data collection. Biannual clinical, virological monitoring performed. Primary endpoints were adequate response (plasma HIV-1 RNA<400 copies/ml), full suppression RNA<50 copies/ml) treatment...
Background. In sub-Saharan Africa, the number of persons living with human immunodeficiency virus (HIV) has increased immensely. parallel, rates noncommunicable diseases, especially cardiovascular disease, are rising rapidly in resource-limited settings. This study aims to evaluate relation between subclinical atherosclerosis and HIV-related traditional risk factors HIV-infected patients rural South Africa.
Abstract Verona Integron-encoded Metallo-beta-lactamase (VIM) is the most frequently-encountered carbapenemase in healthcare-related pathogen Pseudomonas aeruginosa . In Netherlands, a low-endemic country for antibiotic-resistant bacteria, no national surveillance data on prevalence of carbapenemase-producing P. (CPPA) was available. Therefore, 2016, pilot study initiated to investigate occurrence, molecular epidemiology, genetic characterization, and resistomes CPPA among isolates submitted...
Abstract Background After the lifting of most COVID-19 control measures, many infectious diseases re-emerged in 2022. A strong increase invasive group streptococcal (iGAS) infections, among both adults and young children, was reported by several countries. Viral infections such as influenza varicella, known risk factors for iGAS infection, also increased during We estimated proportion GAS skin soft tissue (SSTI) children aged 0-5 years attributable to pneumonia/sepsis respiratory viruses...
Abstract Objectives To determine trends, seasonality and the association between community antibiotic use antimicrobial resistance (AMR) in Escherichia coli Klebsiella pneumoniae urinary tract infections. Methods We analysed Dutch national databases from January 2008 to December 2016 regarding AMR for nitrofurantoin, trimethoprim, fosfomycin ciprofloxacin. Antibiotic was expressed as DDD/1000 inhabitant-days (DID) percentage of total tested isolates. Temporal trends were with autoregressive...
In this retrospective observational study, we analysed a community outbreak of impetigo with meticillin-resistant Staphylococcus aureus (MRSA), additional resistance to fusidic acid (first-line treatment). The occurred between June 2018 and January 2020 in the eastern part Netherlands an epidemiological link three cases from north-western part. Forty nine eight carrier were identified, including 47 children. All but one case had community-onset symptoms. Pharmacy prescription data for...
Context As life expectancy improves among Human Immunodeficiency Virus (HIV) patients, renal and cardiovascular diseases are increasingly prevalent in this population. Renal disease mutual risk factors characterized by albuminuria. Understanding the interactions between HIV, is first step tackling new therapeutic frontier HIV. Methods In a rural primary health care centre, 903 HIV-infected adult patients were randomly selected data on HIV-infection collected. Glomerular filtration rate...
During October-December 2015, 29 patients in a hospital the Netherlands acquired nosocomial infection with multidrug-resistant, New Delhi-metallo-β-lactamase-positive Klebsiella pneumoniae strain. Extensive control measures were needed to stop this outbreak. The estimated economic impact of outbreak was $804,263; highest costs associated bed closures.
Emergence of urine-associated Escherichia coli ST38 producing OXA-244 harbouring putative uropathogenicity factors in the Netherlands.
Direct health effects of antibiotic resistance are difficult to assess. We quantified the risk recurrent bacteremia associated with resistance.We extracted antimicrobial susceptibility testing data on blood isolates from Dutch surveillance system for between 2008 and 2017. First first (4-30 days) episodes were categorized as susceptible, single nonsusceptible, or co-nonsusceptible third-generation cephalosporins without carbapenems (Enterobacteriaceae), ceftazidime (Pseudomonas species),...
HIV-associated Pneumocystis jirovecii pneumonia (PJP) remains one of the commonest opportunistic infections in Western countries. Although it has been suggested that racial differences PJP incidence exist, early studies report conflicting results. This study aimed to investigate a developed country among patients originating from sub-Saharan Africa compared with other regions origin.A retrospective observational cohort was performed 13,844 HIV-infected Dutch ATHENA cohort. The main outcome...
Seven hospitals participated in the Dutch national surveillance for ventilator-associated pneumonia (VAP) and its risk factors. We analysed time-independent time-dependent factors VAP using standard Cox regression flexible Weighted Cumulative Effects method (WCE) that evaluates both current past exposures. The prospective of intensive care patients aged ≥16 years ventilated ≥48 hours resulted inclusion 940 primary ventilation periods, comprising 7872 days. average incidence density was...
Carbapenemases produced by Enterobacterales are often encoded genes on transferable plasmids and represent a major healthcare problem, especially if the contain additional antibiotic resistance genes. As part of Dutch national surveillance, 50 medical microbiological laboratories submit their isolates suspected carbapenemase production to National Institute for Public Health Environment characterization. All which is confirmed subjected next-generation sequencing.To study molecular...
BackgroundThe COVID-19 pandemic resulted in adaptation infection control measures, increased patient transfer, high occupancy of intensive cares, downscaling non-urgent medical procedures and decreased travelling.AimTo gain insight the influence these changes on antimicrobial resistance (AMR) prevalence Netherlands, a country with low AMR prevalence, we estimated demographics six highly resistant microorganisms (HRMO) hospitalised patients Netherlands during waves (March-June 2020, October...
Colistin is a last-resort treatment option for infections with multidrug-resistant Gram-negative bacteria. However, colistin resistance increasing.A six-month prospective matched case-control study was performed in which 22 Dutch laboratories 32 associated hospitals participated. Laboratories were invited to send maximum of five colistin-resistant Escherichia coli or Klebsiella pneumoniae (COLR-EK) isolates and colistin-susceptible (COLS-EK) the reference laboratory, patient location,...