A5059657091- Venous Thromboembolism Diagnosis and Management
- Mycobacterium research and diagnosis
- Tuberculosis Research and Epidemiology
- Complement system in diseases
- Infectious Diseases and Mycology
- Travel-related health issues
- Atrial Fibrillation Management and Outcomes
- Antifungal resistance and susceptibility
- Diagnosis and Treatment of Venous Diseases
- Pneumocystis jirovecii pneumonia detection and treatment
- Pneumonia and Respiratory Infections
- Blood Coagulation and Thrombosis Mechanisms
- Quinazolinone synthesis and applications
- Surgical site infection prevention
- Acute Ischemic Stroke Management
- Bacteriophages and microbial interactions
- Bacterial Infections and Vaccines
- Cytomegalovirus and herpesvirus research
- Clinical practice guidelines implementation
- Psoriasis: Treatment and Pathogenesis
- Central Venous Catheters and Hemodialysis
- Polyomavirus and related diseases
- Skin Protection and Aging
- Antibiotic Resistance in Bacteria
- Glycosylation and Glycoproteins Research
Admiraal De Ruyter Ziekenhuis
2019-2024
University Medical Center Utrecht
2000-2023
Radboud University Nijmegen
2008-2022
Radboud University Medical Center
2008-2022
Radboud Institute for Molecular Life Sciences
2021
Leiden University Medical Center
2006-2019
National Institute for Public Health and the Environment
2017
Academic Medical Center
2006-2015
Slotervaartziekenhuis
2008-2012
The Netherlands Cancer Institute
2008
Non-tuberculous mycobacteria (NTM) infections are hard to treat. New antimicrobial drugs and smarter combination regimens needed.Our aim was determine the in vitro activity of bedaquiline against NTM assess its synergy with established antimycobacterials.We determined MICs for clinically relevant species Mycobacterium tuberculosis by broth microdilution 30 isolates. Synergy testing performed using chequerboard method 22 reference strains clinical isolates abscessus (MAB) avium complex (MAC)....
We report a case of 58-year-old renal transplant patient who developed recurrent urinary tract infection with an extended-spectrum β-lactamase (ESBL)-positive Klebsiella pneumoniae strain in the first month posttransplant. Even though it tested susceptible to carbapenems and despite repeated meropenem treatment, his recurred. The eventually evolved into epididymitis that was successfully treated bacteriophages. This demonstrates difficulty treating relapsing ESBL-positive Gram-negative...
The risk of venous thrombosis is approximately 2- to 4-fold increased after air travel, but the absolute unknown. objective this study was assess travel.We conducted a cohort among employees large international companies and organisations, who were followed between 1 January 2000 31 December 2005. occurrence symptomatic linked exposure as assessed by travel records provided organisations. A long-haul flight defined at least 4 h participants considered exposed for postflight period 8 wk....
Recent evidence suggests that higher rifampicin doses may improve tuberculosis (TB) treatment outcome.In this observational cohort study we evaluated all TB patients who were treated with high-dose (> 10 mg/kg daily) in our reference centre, from January 2008 to May 2018. Indications, achieved plasma exposures, safety and tolerability evaluated.Eighty-eight included. The main indications low concentrations (64.7%) severe illness (29.5%), including central nervous system TB. Adjusted dosages...
Selective oropharyngeal decontamination (SOD) and selective of the digestive tract (SDD) are associated with improved outcomes among patients in intensive care units (ICUs), but uncertainty remains about their long-term effects on resistance levels. We determined trends antibiotic Gram-negative bacteria 38 Dutch ICUs using not SOD/SDD.The Infectious Disease Surveillance Information System-Antibiotic Resistance (ISIS-AR) was used to identify all Enterobacteriaceae, Pseudomonas aeruginosa...
Detection of the source Clostridium difficile strains is importance for control nosocomial spread this microorganism. For purpose, vaginal and rectal swabs from 183 mothers, duplicate fecal samples (taken on days 1 4 after birth) neonates, 94 environmental were cultured C. difficile. The microorganism was never detected in meconium obtained day birth. On other hand, an incidence 17% positivity noted Forty-two percent 31 colonized neonates had been delivered with complications. bacteria...
ABSTRACT We have assessed matrix-assisted laser desorption ionization–time of flight mass spectrometry (MALDI-TOF MS) identification (Bruker) nontuberculous mycobacteria from newly positive liquid cultures respiratory samples. Twelve (22%) 54 isolates were identified directly medium. After subculture and with manual operation, this rose to 49/54 (91%). MALDI-TOF MS is less promising than previously suggested.
Introduction Patients with a first venous thromboembolism (VTE) are at risk of recurrence. Recurrent VTE (rVTE) can be prevented by extended anticoagulant therapy, but this comes the cost an increased bleeding. It is still uncertain whether patients intermediate recurrence or high and bleeding will benefit from treatment, strategy where duration tailored on predicted risks rVTE improve outcomes. The aim Leiden Thrombosis Recurrence Risk Prevention (L-TRRiP) study to evaluate outcomes...
Mannose-binding lectin (MBL) is a serum complement factor playing dominant role in first-line defense. When MBL binds to specific sugar moieties on microorganisms, the pathway (LCP) activated. Changes mbl gene and promotor may result with less activity, predisposing individual recurrent infections. Using functional assay, we investigated at what concentration different microbes activated MBL. Less than 1 colony-forming unit (CFU) of Neisseria meningitidis groups B C still MBL, which be...
We report the case of a kidney transplant recipient with invasive aspergillosis due to Aspergillus fumigatus resistant voriconazole and intermediately susceptible posaconazole who failed therapy. Plasma concentrations indicated an unfavorable ratio area under concentration-time curve over MIC. Posaconazole should be used caution for caused by strains attenuated susceptibility, as drug exposure may inadequate, resulting in therapeutic failure.
Mycobacterium marinum is a nontuberculous mycobacterium that causes skin and soft tissue infections. Treatment consists of multiple antibiotics, sometimes combined with surgical debridement. There little evidence for the choice duration treatment, role susceptibility testing.We performed retrospective cohort study culture-confirmed M. infections in Netherlands 2011-2018 period. Clinical characteristics, vitro susceptibility, extent disease, treatment regimens, outcomes were analyzed....
Antibody replacement therapy for patients with antibody deficiencies contains only IgG. As a result, concurrent IgM and IgA deficiency present in large proportion of deficient persists. Especially remain at risk recurrent infections the gastrointestinal respiratory tract. The lack current IgG is likely to contribute persistence these mucosal because this class especially important complement activation on surface. We evaluated whether supplementation increased serum bactericidal capacity...