A5053049764- Antibiotic Resistance in Bacteria
- Antimicrobial Resistance in Staphylococcus
- Bacterial Identification and Susceptibility Testing
- Antibiotic Use and Resistance
- Pneumonia and Respiratory Infections
- Nosocomial Infections in ICU
- Enterobacteriaceae and Cronobacter Research
- Pharmaceutical and Antibiotic Environmental Impacts
- Urinary Tract Infections Management
- SARS-CoV-2 and COVID-19 Research
- SARS-CoV-2 detection and testing
- Surgical site infection prevention
- Antibiotics Pharmacokinetics and Efficacy
- Mycobacterium research and diagnosis
- Patient Satisfaction in Healthcare
- Clostridium difficile and Clostridium perfringens research
- Bacterial biofilms and quorum sensing
- Cardiac, Anesthesia and Surgical Outcomes
- Healthcare cost, quality, practices
- Biosensors and Analytical Detection
- Infection Control in Healthcare
- Vibrio bacteria research studies
- Streptococcal Infections and Treatments
- Respiratory viral infections research
- COVID-19 Clinical Research Studies
University Medical Center Utrecht
2016-2025
Utrecht University
2017-2025
Amphia Ziekenhuis
2015-2024
Heidelberg University
2015-2023
University Hospital Heidelberg
2015-2023
Elisabeth-TweeSteden Ziekenhuis
2005-2021
Bravis Ziekenhuis
2020
Oklahoma State University Center for Health Sciences
2015-2020
University of Antwerp
2019
Ghent University Hospital
2019
Nasal carriers of Staphylococcus aureus are at increased risk for health care-associated infections with this organism. Decolonization nasal and extranasal sites on hospital admission may reduce risk.In a randomized, double-blind, placebo-controlled, multicenter trial, we assessed whether rapid identification S. by means real-time polymerase-chain-reaction (PCR) assay, followed treatment mupirocin ointment chlorhexidine soap, reduces the hospital-associated infection.From October 2005...
Selective digestive tract decontamination (SDD) and selective oropharyngeal (SOD) are infection-prevention measures used in the treatment of some patients intensive care, but reported effects on patient outcome conflicting.
Abstract In 2003 in the Netherlands, a new methicillin-resistant Staphylococcus aureus (MRSA) strain emerged that could not be typed with Sma1 pulsed-field gel electrophoresis (NT-MRSA). The association of NT-MRSA humans reservoir animals was investigated. frequency increased from 0% 2002 to >21% after intensified surveillance implemented July 2006. Geographically, clustered pig farming. A case–control study showed carriers were more often or cattle farmers (pig odds ratio [OR] 12.2, 95%...
The choice of empirical antibiotic treatment for patients with clinically suspected community-acquired pneumonia (CAP) who are admitted to non-intensive care unit (ICU) hospital wards is complicated by the limited availability evidence. We compared strategies (allowing deviations medical reasons) beta-lactam monotherapy, beta-lactam-macrolide combination therapy, or fluoroquinolone monotherapy.In a cluster-randomized, crossover trial rotated in 4-month periods, we tested noninferiority...
<h3>Importance</h3> On February 27, 2020, the first patient with coronavirus disease 2019 (COVID-19) was reported in Netherlands. During following weeks, at 2 Dutch teaching hospitals, 9 health care workers (HCWs) received a diagnosis of COVID-19, 8 whom had no history travel to China or northern Italy, raising question whether undetected community circulation occurring. <h3>Objective</h3> To determine prevalence and clinical presentation COVID-19 among HCWs self-reported fever respiratory...
10 days after the first reported case of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in Netherlands (on Feb 27, 2020), 55 (4%) 1497 health-care workers nine hospitals located south had tested positive for SARS-CoV-2 RNA. We aimed to gain insight possible sources workers.We did a cross-sectional study at three Netherlands. screened participating infection, based on clinical symptoms (fever or mild symptoms) before screening. obtained epidemiological data through...
Background.The worldwide prevalence of extended-spectrum β-lactamase (ESBL)-producing Enterobacteriaceae is increasing rapidly both in hospitals and the community.A connection between ESBL-producing bacteria food animals, retail meat, humans has been suggested.We previously reported on genetic composition a collection Escherichia coli (ESBL-EC) from chicken meat restricted geographic area.Now, we have extended analysis with plasmid replicons, virulence factors, highly discriminatory genomic...
The lack of new antibiotic classes calls for a cautious use existing agents. Yet, every 10 min, almost two tons antibiotics are used around the world, all too often without any prescription or control. use, overuse and misuse select resistance in numerous species bacteria which then renders antimicrobial treatment ineffective. Almost countries face increased (AMR), not only humans but also livestock along food chain. spread AMR is fueled by growing human animal populations, uncontrolled...
To determine the relative importance of different risk factors for development surgical-site infections (SSIs) in orthopedic surgery with prosthetic implants.In a cohort 272 patients, following possible were studied: age, gender, method hair removal, duration operation, surgeon, underlying illness, and nasal carriage Staphylococcus aureus. Infections recorded Centers Disease Control criteria. The relation between SSI was tested univariate multiple logistic regression analysis.Community...
Abstract Objective: To test the hypothesis that perioperative elimination of nasal carriage Staphylococcus aureus using mupirocin ointment reduces surgical-site infection (SSI) rate in cardiothoracic surgery. Design: Unblinded intervention trial with historical controls. Setting: A university hospital, tertiary referral center for Patients: Consecutive patients undergoing surgery between August 1, 1989, and February 1991 (historical control group), March 1991, 1992 (intervention group)....
ABSTRACT Increasing antibiotic resistance in gram-negative bacteria has recently renewed interest colistin as a therapeutic option. The increasing use of necessitates the availability rapid and reliable methods for susceptibility testing. We compared seven testing (disk diffusion, agar dilution on Mueller-Hinton [MH] Isosensitest agar, Etest MH broth microdilution, VITEK 2) 102 clinical isolates collected from patient materials during selective digestive decontamination or oral trial an...
To estimate the proportion of methicillin-resistant Staphylococcus aureus (MRSA) isolates from humans that were sequence type (ST) 398, we surveyed 24 laboratories in 17 countries Europe 2007. Livestock-associated MRSA ST398 accounted for only a small humans; most Netherlands, Belgium, Denmark, and Austria.
In The Netherlands, patients exposed to pigs or veal calves were recently shown be at high risk of methicillin-resistant Staphylococcus aureus (MRSA) carriage. Amphia Hospital (Breda, Netherlands), 32% in this group carry MRSA. This resulted a 3-fold increase the annual MRSA incidence.
ABSTRACT Selective decontamination of the digestive tract (SDD) selectively eradicates aerobic Gram-negative bacteria (AGNB) by enteral administration oral nonabsorbable antimicrobial agents, i.e., colistin and tobramycin. We retrospectively investigated impact SDD, applied for 5 years as part an infection control program outbreak with extended-spectrum beta-lactamase (ESBL)-producing Klebsiella pneumoniae in intensive care unit (ICU), on resistance among AGNB. Colistin MICs were determined...
ObjectivesThe objectives of this study were to determine the prevalence carriage ESBL-producing Enterobacteriaceae (ESBL-E) in a representative sample general adult Dutch community, identify risk factors and gain understanding epidemiology these resistant strains.
Background Surgical Site Infections (SSI) are relatively frequent complications after colorectal surgery and associated with substantial morbidity mortality. Objective Implementing a bundle of care measuring the effects on SSI rate. Design Prospective quasi experimental cohort study. Methods A prospective surveillance for was performed in Amphia Hospital, Breda, from January 1, 2008 until 2012. As part National patient safety initiative, consisting 4 elements covering surgical process...
To rapidly assess possible community transmission in Noord-Brabant, the Netherlands, healthcare workers (HCW) with mild respiratory complaints and without epidemiological link (contact confirmed case or visited areas active circulation) were tested for severe acute syndrome coronavirus 2 (SARS-CoV-2). Within days, 1,097 HCW nine hospitals tested; 45 (4.1%) positive. Of six positive HCW, two accounted 38 HCW. The results informed local national risk management.