A5019221575- Respiratory Support and Mechanisms
- Intensive Care Unit Cognitive Disorders
- Cardiac Arrest and Resuscitation
- Sepsis Diagnosis and Treatment
- Hemodynamic Monitoring and Therapy
- Immune Response and Inflammation
- Thermal Regulation in Medicine
- Family and Patient Care in Intensive Care Units
- Traumatic Brain Injury and Neurovascular Disturbances
- Cardiac, Anesthesia and Surgical Outcomes
- Neonatal Respiratory Health Research
- Anesthesia and Neurotoxicity Research
- Non-Invasive Vital Sign Monitoring
- Heart Rate Variability and Autonomic Control
- Anesthesia and Sedative Agents
- Neuroscience of respiration and sleep
- Frailty in Older Adults
- Ultrasound in Clinical Applications
- Airway Management and Intubation Techniques
- Long-Term Effects of COVID-19
- Renal function and acid-base balance
- Mechanical Circulatory Support Devices
- Palliative Care and End-of-Life Issues
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Patient Safety and Medication Errors
Radboud University Nijmegen
2016-2025
Radboud University Medical Center
2016-2025
University Medical Center
2014-2024
Radboud Institute for Molecular Life Sciences
2015-2021
General Department of Preventive Medicine
2020
Ziekenhuis Bernhoven
2020
Streekziekenhuis Koningin Beatrix
2020
Catharina Ziekenhuis
2020
Ziekenhuis Groep Twente
2020
University Medical Center Utrecht
2019
Selective digestive tract decontamination (SDD) and selective oropharyngeal (SOD) are infection-prevention measures used in the treatment of some patients intensive care, but reported effects on patient outcome conflicting.
<b>Objectives</b> To develop and validate a delirium prediction model for adult intensive care patients determine its additional value compared with by caregivers. <b>Design</b> Observational multicentre study. <b>Setting</b> Five units in the Netherlands (two university hospitals three affiliated teaching hospitals). <b>Participants</b> 3056 aged 18 years or over. <b>Main outcome measure</b> Development of (defined as at least one positive screening) during patients’ stay care....
Objective: To examine the impact of delirium during intensive care unit stay on long-term health-related quality life and cognitive function in survivors. Design: Prospective 18-month follow-up study. Setting: Four units a university hospital. Patients: A median 18 months after discharge, questionnaires were sent to 1,292 survivors with (n = 272) without 1020) their stay. Measurements Main Results: The Short Form-36v1, checklist individual strength-fatigue, failure questionnaire used....
<h3>Importance</h3> One-year outcomes in patients who have had COVID-19 and received treatment the intensive care unit (ICU) are unknown. <h3>Objective</h3> To assess occurrence of physical, mental, cognitive symptoms among with at 1 year after ICU treatment. <h3>Design, Setting, Participants</h3> An exploratory prospective multicenter cohort study conducted ICUs 11 Dutch hospitals. Patients (N = 452) COVID-19, aged 16 years older, alive hospital discharge following admission to during first...
Significance Hitherto, both the autonomic nervous system and innate immune were regarded as systems that cannot be voluntarily influenced. The present study demonstrates that, through practicing techniques learned in a short-term training program, sympathetic can indeed Healthy volunteers exhibited profound increases release of epinephrine, which turn led to increased production anti-inflammatory mediators subsequent dampening proinflammatory cytokine response elicited by intravenous...
<h3>Importance</h3> Results of studies on use prophylactic haloperidol in critically ill adults are inconclusive, especially patients at high risk delirium. <h3>Objective</h3> To determine whether improves survival among delirium, which was defined as an anticipated intensive care unit (ICU) stay least 2 days. <h3>Design, Setting, and Participants</h3> Randomized, double-blind, placebo-controlled investigator-driven study involving 1789 treated 21 ICUs, nonpharmacological interventions for...
Evidence has accumulated that respiratory muscle dysfunction develops in critically ill patients and contributes to prolonged weaning from mechanical ventilation. Accordingly, it seems highly appropriate monitor the muscles these patients. Today, we are only at beginning of routinely monitoring function. Indeed, most clinicians do not evaluate function all. In our opinion, however, practical issues absence sound scientific data for clinical benefit should discourage having a closer look This...
Rationale: Comprehensive studies addressing the incidence of physical, mental, and cognitive problems after ICU admission are lacking. With an increasing number survivors, improved understanding post-ICU is necessary. Objectives: To determine occurrence cooccurrence new among survivors 1 year admission, their impact on daily functioning, risk factors associated with 1-year outcomes. Methods: Prospective multicenter cohort study, including patients ⩾16 years age, admitted for ⩾12 hours...
Abstract Background Temperature management is used with increased frequency as a tool to mitigate neurological injury. Although frequently used, little known about the optimal cooling methods for inducing and maintaining controlled normo- hypothermia in intensive care unit (ICU). In this study we compared efficacy of several commercially available devices temperature ICU patients various types Methods Fifty adult an indication mild or strict normothermia were prospectively enrolled. Ten each...
Reversal of sepsis-induced immunoparalysis may reduce the incidence secondary infections and improve outcome. Although IFN-γ granulocyte-macrophage colony-stimulating factor (GM-CSF) restore immune competence ex vivo stimulated leukocytes patients with sepsis, effects on in are not known.To investigate GM-CSF humans.We performed a double-blind, placebo-controlled, randomized study 18 healthy male volunteers that received Escherichia coli endotoxin (LPS; 2 ng/kg, intravenously) days 1 7...
Heparin is the most widely used anticoagulant in continuous renal replacement procedures but little known about balance between filter coagulation and patient hemorrhage during treatment. Filter survival hemorrhagic complications 240 periods 78 critically ill patients, treated with arteriovenous hemofiltration hemodiafiltration, were studied for this article. The crude incidence of was 17.7 +/- 2.5 (mean SE) per 1000 h at an activated partial thromboplastin time (APTT) 15 to 35 s, as...
Abstract Introduction To evaluate whether alkaline phosphatase (AP) treatment improves renal function in sepsis-induced acute kidney injury (AKI), a prospective, double-blind, randomized, placebo-controlled study critically ill patients with severe sepsis or septic shock evidence of AKI was performed. Methods Thirty-six adult according to Systemic Inflammatory Response Syndrome criteria and defined the Network were included. Dialysis intervention standardized Acute Quality Initiative...
Delirium occurs frequently in critically ill patients and is associated with disease severity infection. Although several pathways for delirium have been described, biomarkers intensive care unit (ICU) not well studied. We examined plasma delirious nondelirious the role of these on long-term cognitive function.In an exploratory observational study, we included 100 ICU or without ("inflamed") ("noninflamed") infection/systemic inflammatory response syndrome (SIRS). was diagnosed by using...
Objective: To determine gender differences in the innate immune response and vascular reactivity during human endotoxemia. Design: Clinical experimental study. Setting: University medical center intensive care research unit. Subjects: Fifteen female 15 male volunteers. Interventions: Intravenous injection of 2 ng/kg Escherichia coli lipopolysaccharide. Measurements Main Results: C-reactive protein, leukocytes, cytokines were measured at regular time intervals as indicators inflammation....
Obesity is associated with a variety of diseases, which results in decreased overall life expectancy. Nevertheless, some studies suggest that being overweight may reduce hospital mortality certain patient groups, referred to as obesity paradox. Conflicting for critically ill patients are reported. Therefore, we wished investigate the association body mass index and patients.Observational cohort study Dutch patients.A dataset from National Intensive Care Evaluation registry includes admitted...
Implementation of strict glucose control in most intensive care units has resulted increased use point-of-care devices the unit. The aim this study was to determine reliability testing meters among critically ill patients under insulin treatment.Prospective observational study.Intensive unit and non-intensive a tertiary teaching hospital.A oxidase method used validate devices. Three different devices, Accu-Chek Sensor (Roche Diagnostics), Precision (Abbott HemoCue were tested. Glucose...
Alkaline phosphatase (AP) attenuates inflammatory responses by lipopolysaccharide detoxification and may prevent organ damage during sepsis. To investigate the effect of AP in patients with severe sepsis or septic shock on acute kidney injury.A multicenter double-blind, randomized, placebo-controlled phase IIa study (2:1 ratio).Thirty-six intensive care unit (20 men/16 women, mean age 58 +/- 3 years) a proven suspected Gram-negative bacterial infection, >or=2 systemic response syndrome...
Endotoxin (lipopolysaccharide [LPS]) tolerance is characterized by a reduced responsiveness to subsequent LPS challenge. In animal and human in vitro experiments, associated with an attenuated response of proinflammatory cytokines enhanced production anti-inflammatory cytokines. It unclear if this mechanism accounts for the development humans vivo.Clinical experimental study.Intensive care research unit.Fourteen healthy male volunteers.Intravenous injections 2 ng/kg/day Escherichia coli on 5...