A5065781665- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- RNA Research and Splicing
- Fungal and yeast genetics research
- Antibiotic Use and Resistance
- Developmental Biology and Gene Regulation
- RNA and protein synthesis mechanisms
- Antibiotic Resistance in Bacteria
- Pneumonia and Respiratory Infections
- Invertebrate Immune Response Mechanisms
- Genomics and Chromatin Dynamics
- Lipid Membrane Structure and Behavior
- Animal Genetics and Reproduction
- Antimicrobial Resistance in Staphylococcus
- Neurobiology and Insect Physiology Research
- Microtubule and mitosis dynamics
- Ubiquitin and proteasome pathways
- Cytokine Signaling Pathways and Interactions
- Ethics in Clinical Research
- Ethics in medical practice
- Vibrio bacteria research studies
- CRISPR and Genetic Engineering
- Biomedical Ethics and Regulation
- Bacterial Identification and Susceptibility Testing
- Bacteriophages and microbial interactions
Wellcome Trust
2024-2025
Princeton University
1994-2005
Stony Brook University
1999
Harvard University
1994-1996
Dana-Farber Cancer Institute
1994
RNA-binding proteins have been suggested to move in association with RNA as it leaves the nucleus. The NPL3 gene of yeast Saccharomyces cerevisiae encodes nuclear protein consensus motifs and similarity heterogeneous ribonucleoproteins members S/R family. We show that although Npl3 is located nucleus, can shuttle between nuclei heterokaryons. In contrast, other nucleus-targeted do not leave nucleus under similar conditions. Mutants missing or N terminus are still capable shuttling out...
The virulence of Salmonella typhimurium for mice results, in part, from its ability to survive after phagocytosis by macrophages. Although it is generally agreed that intracellular bacteria persist membrane-bound phagosomes, there remains some question as whether these phagosomes fuse with macrophage lysosomes. This report describes the maturation containing S. inside mouse bone marrow-derived Macrophages were infected briefly and incubated various intervals; then they examined fluorescence...
The NUF2 gene of the yeast Saccharomyces cerevisiae encodes an essential 53-kd protein with a high content potential coiled-coil structure similar to myosin. Nuf2 is associated spindle pole body (SPB) as determined by coimmunofluorescence known SPB proteins. appears be localized intranuclear region and candidate for involved in separation. nuclear association can disrupted, part, 1 M salt but not detergent Triton X-100. All removed from nuclei 8 urea extraction. In this regard, other...
RNA-binding proteins have been suggested to move in association with RNA as it leaves the nucleus. The NPL3 gene of yeast Saccharomyces cerevisiae encodes nuclear protein consensus motifs and similarity heterogeneous ribonucleoproteins members S/R family. We show that although Npl3 is located nucleus, can shuttle between nuclei heterokaryons. In contrast, other nucleus-targeted do not leave nucleus under similar conditions. Mutants missing or N terminus are still capable shuttling out...
Antimicrobial resistance (AMR) is a global public health challenge. Global efforts to decrease AMR through antimicrobial stewardship (AMS) initiatives include education and optimising the use of diagnostic technologies antibiotics. Despite this, economic societal challenges hinder AMS efforts. The objective this study was obtain insights from healthcare professionals (HCPs) on current identify opportunities for test utilisation Three hundred HCPs six countries (representing varied gross...
<ns3:p>The increasing threat from infection with drug-resistant pathogens is among the most serious public health challenges of our time. Formed by Wellcome in 2018, Surveillance and Epidemiology Drug-Resistant Infections Consortium (SEDRIC) an international think tank whose aim to inform policy change way countries track, share, analyse data relating infections, defining knowledge gaps identifying barriers delivery global surveillance. SEDRIC delivers its aims through discussions analyses...
ABSTRACT Runt functions as a transcriptional regulator in multiple developmental pathways Drosophila melanogaster. Recent evidence indicates that represses the transcription of several downstream target genes segmentation pathway. Here we demonstrate runt also to activate transcription. The initial expression female-specific sex-determining gene Sex-lethal blastoderm embryo requires activity. Consistent with role direct activator, shows sequence-specific binding sites early promoter. Using...
For Drosophila melanogaster flies, sexual fate is determined by the X chromosome number. The basic helix-loop-helix protein product of X-linked sisterlessB(sisB or scute) gene a key indicator dose and functions to activate switch Sex-lethal (Sxl) in female (XX), but not male (XY), embryos. Zygotically expressed sisB maternal daughterless (da)proteins are known form heterodimers that bind E-box sites transcription. We examined SISB-Da binding atSxl using footprinting gel mobility shift assays...