A5007148840- Neuroscience and Neuropharmacology Research
- Photoreceptor and optogenetics research
- Neural dynamics and brain function
- Retinal Development and Disorders
- Neuroscience and Neural Engineering
- Neurobiology and Insect Physiology Research
- Neural Networks and Applications
- Zebrafish Biomedical Research Applications
- Visual perception and processing mechanisms
- Viral Infectious Diseases and Gene Expression in Insects
- Monoclonal and Polyclonal Antibodies Research
- Metabolism and Genetic Disorders
- Pain Mechanisms and Treatments
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Axon Guidance and Neuronal Signaling
- Protein Tyrosine Phosphatases
- EEG and Brain-Computer Interfaces
- Genetics and Neurodevelopmental Disorders
- RNA regulation and disease
- Advanced Memory and Neural Computing
- Memory and Neural Mechanisms
- Insect and Arachnid Ecology and Behavior
- Neuroinflammation and Neurodegeneration Mechanisms
- Endoplasmic Reticulum Stress and Disease
- Receptor Mechanisms and Signaling
Kunming Medical University
2025
Carnegie Mellon University
2020-2024
Columbia University
1998-2021
Brain (Germany)
2021
Chan Zuckerberg Initiative (United States)
2021
Kavli Institute for Theoretical Sciences
2021
Boston Children's Hospital
2011-2018
Harvard University
2003-2018
Allen Institute for Brain Science
2018
Harvard University Press
2009
Signal transducer and activator of transcription (STAT) proteins are both tyrosine- serine-phosphorylated, mediating signal transduction gene regulation. Following regulation, STAT activity in the nucleus is then terminated by a nuclear protein phosphatase(s), which remains unidentified. Using novel antibody arrays to screen Stat1-specific we identified SHP-2-Stat1 interaction A431 cell nucleus. SHP-2 Stat1 localization their association response either epidermal growth factor or...
Mouse retinal ganglion cells (RGCs) have been classified into around 20 subtypes based on the shape, size, and laminar position of their dendritic arbors. In most cases tested, RGC in this manner also distinct functional signatures. Here we asked whether defined by morphology stereotyped axonal arbors main central target, superior colliculus (SC). We used transgenic viral methods to sparsely label RGCs characterized both individual RGCs. Axon varied position. For each 12 dendritically,...
Skilled motor behavior requires rapidly integrating external sensory input with information about internal state to decide which movements make next. Using machine learning approaches for high-resolution kinematic analysis, we uncover the logic of a rapid decision underlying sensory-guided locomotion in mice. After detecting obstacles their whiskers mice select distinct strategies depending on whisker-derived estimate obstacle location together position and velocity body. Although rely...
Neocortical sensory areas have associated primary and secondary thalamic nuclei. While nuclei transmit information to cortex, remain poorly understood. We recorded juxtasomally from somatosensory (POm) visual (LP) of awake mice while tracking whisking pupil size. POm activity correlated with whisking, but not precise whisker kinematics. This coarse movement modulation persisted after facial paralysis thus was due reafference. phenomenon also continued during optogenetic silencing motor...
Summary The neocortex, comprised of multiple distinct layers, processes sensory input from the periphery, makes decisions, and executes actions. Despite extensive investigation cortical anatomy physiology, contributions different layers to guided behaviors remain unknown. Here, we developed a two-alternative forced choice (2AFC) paradigm in which head-fixed mice use single whisker either discriminate textures parametrically varied roughness or detect same textured surfaces. Lesioning barrel...
For Drosophila melanogaster flies, sexual fate is determined by the X chromosome number. The basic helix-loop-helix protein product of X-linked sisterlessB(sisB or scute) gene a key indicator dose and functions to activate switch Sex-lethal (Sxl) in female (XX), but not male (XY), embryos. Zygotically expressed sisB maternal daughterless (da)proteins are known form heterodimers that bind E-box sites transcription. We examined SISB-Da binding atSxl using footprinting gel mobility shift assays...
We analyzed the acquisition of fluorescence a GFP fusion protein expressed from gene constructs designed to regulate either time translation or transcription. Both with wild-type appended N-terminus Bicoid (Bcd) transcription factor. One construct, P[gfp-bcd] an mRNA that was initially translated at egg deposition. GFP–Bcd could first be detected in anterior nuclei embryo syncytial blastoderm stage, within 1.5–2.5 h after commenced. The second P[hs-gfp-bcd], utilized thehsp70promoter...
Abstract The retinogeniculate synapse transmits information from retinal ganglion cells ( RGC ) in the eye to thalamocortical relay neurons visual thalamus, dorsal lateral geniculate nucleus dLGN ). Studies mice have identified genetic markers for distinct classes of s encoding different features space, facilitating dissection subtype‐specific physiology and anatomy. In this study, we examine morphological properties axon arbors BD ‐ class ON OFF direction selective that, by definition,...
Abstract All neocortical sensory areas have an associated primary and secondary thalamic nucleus. While the nuclei encode information for transmission to cortex, nature of encoded in is poorly understood. We recorded juxtasomally from neurons somatosensory (POm) visual (LP) awake head-fixed mice with simultaneous whisker tracking pupilometry. POm activity correlated whether or not a mouse was whisking, but precise whisking kinematics. This coarse movement modulation persisted after...
Previous studies have demonstrated that the specificity of Src homology 2 (SH2) and phosphotyrosine-binding domain interactions are mediated by phosphorylated tyrosines their neighboring amino acids. Two first phosphotyrosine-based binding sites were found on middle T antigen polyoma virus. Tyr-250 acts as a site for ShcA, whereas Tyr-315 forms SH2 p85 subunit phosphatidylinositol 3-kinase. However, genetic analysis given phosphotyrosine's role in signaling can be complicated when it serves...
Quantifying relevant interactions between neural populations is a prominent question in the analysis of high-dimensional recordings. However, existing dimension reduction methods often discuss communication absence formal framework, while frameworks proposed to address this gap are impractical data analysis. This work bridges framework M-Information Flow with practical real data. To end, we propose Iterative Regression, message-dependent linear technique that iteratively finds an orthonormal...
Transient global amnesia (TGA) and transient epileptic (TEA) are inherently challenging to diagnose share many similarities, which can easily lead confusion. In this report, we present a case of 57-year-old female patient experienced recurrent with incidentally found chronic ischemic temporo-parietal lesion including hippocampus also revealed frequent interictal epileptiform discharges in acute period be features TEA. We aim explore the differences between TEA TGA through confusing when...