A5112368584- HIV/AIDS drug development and treatment
- Tuberculosis Research and Epidemiology
- Pneumocystis jirovecii pneumonia detection and treatment
- HIV Research and Treatment
- HIV/AIDS Research and Interventions
- Antibiotic Resistance in Bacteria
- Hepatitis C virus research
- HIV-related health complications and treatments
- Mycobacterium research and diagnosis
- Diagnosis and treatment of tuberculosis
Cambodian Institute for Cooperation and Peace
2015-2021
Abstract Introduction : The number of HIV‐infected children and adolescents requiring second‐line antiretroviral treatment (ART) is increasing in low‐ middle‐income countries (LMIC). However, the effectiveness paediatric ART potential risk factors for virologic failure are poorly characterized. We performed an aggregate analysis outcomes assessed need third‐line ART. Methods a multicentre by systematically reviewing literature to identify cohorts receiving LMIC, contacting corresponding...
We determined the prevalence and incidence of liver dysfunction before after initiation combination antiretroviral therapy (cART) in TREAT Asia Pediatric HIV Observational Database.Data from children initiated on cART between 2 18 years age with baseline alanine aminotransferase (ALT) available at least once Database 2008 2012 were analyzed. Prevalence biomarkers including aspartate to platelet ratio index FIB4 (a noninvasive panel stage disease) assessed.Data 1930 included. Their median was...
Introduction Prolonged inpatient multidrug-resistant tuberculosis (MDR-TB) treatment for all patients is not sustainable high-burden settings, but there limited information on community-based programme outcomes MDR-TB. Methods The Cambodian Health Committee, a non-governmental organisation (NGO), launched the MDR-TB in 2006 cooperation with National Tuberculosis Program (NTP) including option as key component. was transferred to NTP oversight 2011 NGO clinical management continuing. Patients...
Limited access to drug susceptibility testing (DST) in referral hospitals contributes delayed detection of multidrug-resistant tuberculosis (MDR-TB).To document the impact identifying rifampicin (RMP) resistance using Xpert(®) MTB/RIF on time diagnosis and treatment, evaluate its performance under programmatic conditions.Using a prospective observational study, we screened presumptive MDR-TB cases with Xpert solid culture/conventional DST. RMP was confirmed line-probe assay (LPA). We...
Due to the emergence of Mycobacterium tuberculosis (M.tb) clinical isolates resistant most potent first-line drugs (FLD), second-line (SLD) are being prescribed more frequently. We explore genetic characteristics and molecular mechanisms M.tb phenotypically SLD, including pre-extensively drug-resistant (pre-XDR) extensively (XDR) isolates.Drug-resistant (DR) collected from 2012 2017 were tested using sequencing phenotypic drug susceptibility testing. Genotypes determined their links with SLD...