A5031077871- HIV/AIDS Research and Interventions
- HIV Research and Treatment
- HIV/AIDS drug development and treatment
- HIV/AIDS Impact and Responses
- Adolescent Sexual and Reproductive Health
- HIV, Drug Use, Sexual Risk
- Global Maternal and Child Health
- Healthcare Systems and Reforms
- Sex work and related issues
- Healthcare Policy and Management
- SARS-CoV-2 and COVID-19 Research
- COVID-19 epidemiological studies
- Pneumocystis jirovecii pneumonia detection and treatment
- HIV-related health complications and treatments
- Mobile Health and mHealth Applications
- COVID-19 Clinical Research Studies
- Immune Cell Function and Interaction
- Vaccine Coverage and Hesitancy
- Mosquito-borne diseases and control
- COVID-19 diagnosis using AI
- SARS-CoV-2 detection and testing
- COVID-19 Impact on Reproduction
- Mycobacterium research and diagnosis
- Leprosy Research and Treatment
- Tuberculosis Research and Epidemiology
Amsterdam Institute for Global Health and Development
2016-2025
Amsterdam University Medical Centers
2018-2025
University of Amsterdam
2016-2025
PharmAccess Group
2012-2024
Vrije Universiteit Amsterdam
2024
Amsterdam UMC Location University of Amsterdam
2011-2023
Joep Lange Institute
2018-2023
Pharmac
2021
University of Oxford
2021
Universitat de Barcelona
2017
Background Cardiovascular disease (CVD) is the leading cause of adult mortality in low-income countries but data on prevalence cardiovascular risk factors such as hypertension are scarce, especially sub-Saharan Africa (SSA). This study aims to assess and determinants blood pressure four SSA populations rural Nigeria Kenya, urban Namibia Tanzania. Methods Findings We performed cross-sectional household surveys Kwara State, Nigeria; Nandi district, Kenya; Dar es Salaam, Tanzania Greater...
ABSTRACT A cross-sectional survey was carried out with 485 healthy working adult Ethiopians who are participating in a cohort study on the progression of human immunodeficiency virus type 1 (HIV-1) infection to establish hematological reference ranges for HIV-negative Ethiopians. In addition, enumeration absolute numbers and percentages leukocyte subsets performed 142 randomly selected individuals. Immunological results were compared those 1,356 Dutch blood donor controls....
This study aimed to investigate the consequences of using clinicoimmunological criteria detect antiretroviral treatment (ART) failure and guide regimen switches in HIV-infected adults sub-Saharan Africa. Frequencies unnecessary switches, patterns HIV drug resistance, risk factors for accumulation nucleoside reverse transcriptase inhibitor (NRTI)-associated mutations were evaluated.Cross-sectional analysis switching ART regimens at 13 clinical sites 6 African countries was performed. Two...
Background. Human immunodeficiency virus type 1 (HIV-1) drug resistance may limit the benefits of antiretroviral therapy (ART). This cohort study examined patterns drug-resistance mutations (DRMs) in individuals with virological failure on first-line ART at 13 clinical sites 6 African countries and predicted their impact second-line susceptibility.
Ghana is one of the sub-Saharan African countries making significant progress towards universal access to quality healthcare. However, it remains a challenge attain 2015 targets for health related Millennium Development Goals (MDGs) partly due sector human resource challenges including low staff motivation. This paper addresses indicators worker motivation and assesses associations with care patient safety in Ghana. The aim identify interventions at level that contribute improvement...
Background Quality care in health facilities is critical for a sustainable insurance system because of its influence on clients' decisions to participate and utilize services. Exploration the different dimensions healthcare quality their associations will help determine more effective improvement interventions sustainability strategies, especially resource constrained countries Africa where universal access good remains challenge. Purpose To examine differences perceptions clients staff if...
Background While HIV testing and counselling is a key entry point for treatment as prevention, over half of HIV-infected adults in Kenya are unaware they infected. Offering self-testing (HST) at community pharmacies may enhance detection undiagnosed infections. We assessed the feasibility pharmacy-based HST Coastal Kenya. Methods Staff five pharmacies, supported by on-site research assistants, recruited adult clients (≥18 years) seeking services indicative risk. Participants were offered...
An increasing number of people on antiretroviral therapy (ART) in sub-Saharan Africa has led to declines HIV related morbidity and mortality. However, virologic failure (VF) acquired drug resistance (ADR) may negatively affect these gains. This study describes the prevalence correlates HIV-1 VF ADR among first-line ART experienced adults at a rural clinic Coastal Kenya. HIV-infected for ≥6 months were cross-sectionally recruited between November 2008 March 2011. The primary outcome was VF,...
Limited availability of viral load (VL) monitoring in HIV treatment programmes sub-Saharan Africa can delay switching to second-line ART, leading the accumulation drug resistance mutations (DRMs). The objective this study was evaluate reverse transcriptase inhibitors after continued virological failure on first-line among adults and children Africa.HIV-1-positive an NNRTI-based ART were included. Retrospective VL and, if ≥1000 copies/mL, pol genotypic testing performed. Among participants...
To assess syncytium-inducing (SI) and non-syncytium-inducing (NSI) frequencies, coreceptor usage gp120 V3 sequences of HIV-1 isolates from Ethiopian AIDS patients.Cross-sectional study on 48 hospitalized patients (CD4 T cells < 200 x 10(6) cell/l) with stage III or IV the WHO staging system for infection disease.Peripheral blood mononuclear (PBMC) all were tested by MT-2 assay to determine SI/NSI phenotypes. Lymphocyte subsets enumerated using Coulter counting FACScan analysis. Viral load...
The increasing prevalence of acquired and transmitted HIV-1 drug resistance is an obstacle to successful antiretroviral therapy (ART) in the low- middle-income countries (LMICs) hardest hit by pandemic. Genotypic testing could facilitate choice initial ART areas with rising (TDR) enable care-providers determine which individuals virological failure (VF) on a first- or second-line regimen require change treatment. An inexpensive near point-of-care (POC) genotypic test would be useful settings...
Background Long-term success of HIV antiretroviral therapy requires near-perfect adherence, maintained throughout one's lifetime. However, perceptions towards ART and patterns adherence may change during the life course. We assessed challenges to long-term in adolescents adults three regional treatment centers Uganda. Methods conducted 24 in-depth interviews 2 focus group discussions with a total 33 health-care providers expert clients (HIV patients on who assist support fellow patients)....
Abstract Introduction : Our understanding of how to achieve optimal long‐term adherence antiretroviral therapy (ART) in settings where the burden HIV disease is highest remains limited. We compared levels and determinants over time between HIV‐positive persons receiving ART who were enrolled a bi‐regional cohort sub‐Saharan Africa Asia. Methods This multicentre prospective study adults starting first‐line assessed patient‐reported at follow‐up clinic visits using 30‐day visual analogue...