Zekarias Gessesse Arefaine

ORCID: 0000-0003-0371-2006
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About
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Research Areas
  • COVID-19 Clinical Research Studies
  • SARS-CoV-2 and COVID-19 Research
  • COVID-19 Impact on Reproduction
  • Parasites and Host Interactions
  • Infection Control and Ventilation
  • Trypanosoma species research and implications
  • Pneumocystis jirovecii pneumonia detection and treatment
  • SARS-CoV-2 detection and testing
  • Healthcare Systems and Reforms
  • Antibiotic Use and Resistance
  • Research on Leishmaniasis Studies
  • Child Nutrition and Water Access
  • Amoebic Infections and Treatments
  • HIV/AIDS Research and Interventions
  • Global Maternal and Child Health
  • Infection Control in Healthcare
  • HIV/AIDS oral health manifestations

Mekelle University
2020-2024

Background Serological testing for SARS-CoV-2 plays an important role epidemiological studies, in aiding the diagnosis of COVID-19, and assess vaccine responses. Little is known on dynamics serology African settings. Here, we aimed to characterize longitudinal antibody response profile Ethiopia. Methods In this prospective study, a total 102 PCR-confirmed COVID-19 patients were enrolled. We obtained 802 plasma samples collected serially. antibodies determined using four lateral flow...

10.1371/journal.pone.0263627 article EN cc-by PLoS ONE 2022-03-23

Introduction All individuals and couples have a basic human right to decide freely responsibly the number, spacing, timing of their child. However, In Ethiopia, prevalence contraceptive utilization remains low it varies in different regions. Therefore, this study was aimed determine determinant factors affecting modern contraception reproductive age group (15–49 years) Edaga-Hamus Town. Methodology A community based Cross-Sectional carried out on April 23 May 10, 2017. systemic random...

10.1371/journal.pone.0227795 article EN cc-by PLoS ONE 2020-03-06

Even though use of antiretroviral therapy (HAART) decreases the incidence opportunistic infections (OIs) they are continuing to be a major cause morbidity and mortality. Studies concerning this problem scarce in Eastern Africa. The aim study was determine predictors OIs after initiation HAART Ethiopia.A health facility based single centered cohort using structured data extraction sheet conducted. population all HIV positive ART naive adolescents adults who started between January 2009 May...

10.1371/journal.pone.0229757 article EN cc-by PLoS ONE 2020-04-20

Background: COVID-19 symptomatology in Africa appears significantly less serious than the industrialized world. We and others previously postulated a partial explanation for this phenomenon, being different, more activated immune system due to parasite infections. investigated hypothesis an endemic area Africa. Methods: Ethiopian patients were enrolled screened intestinal parasites. The primary outcome was proportion of with severe COVID-19. Logistic regression models used estimate...

10.2139/ssrn.3832647 article EN SSRN Electronic Journal 2021-01-01

Background The rapid diagnostic test (RDT) rK39 is currently being used for routine diagnosis of visceral leishmaniasis (VL) in East Africa. However, continuous monitoring the performance assay, particular its impact on clinical decision initiating anti-leishmanial treatment and outcomes remains needed as there are concerns about this test. Methods VL patients prospectively enrolled a trial with RDT were included. We evaluated effect testing guiding initiation outcome. On basis result well...

10.1371/journal.pone.0253303 article EN cc-by PLoS ONE 2021-06-14

Abstract Background B-cell hypo-responsiveness has been associated with intestinal parasitic co-infection. The effect of parasite co-infection on antibody response to SARS-CoV-2 is unknown. Here, we aimed determine among COVID-19 patients co-infected parasites and those without Methods In this prospective cohort study, a total 589 samples were serially collected from 72 RT-PCR-confirmed patients. Anti-SARS-CoV-2 nucleocapsid protein (NP) titers measured longitudinally during hospitalization....

10.1101/2023.08.20.23294345 preprint EN cc-by medRxiv (Cold Spring Harbor Laboratory) 2023-08-21

Background: Serological testing for SARS-CoV-2 plays an important role epidemiological studies, in aiding the diagnosis of COVID-19, and assess vaccine responses. Little is known on dynamics serology African settings. Here, we aimed to characterize longitudinal antibody response profile Ethiopia.Methods: In this prospective study, a total 102 PCR-confirmed COVID-19 patients were enrolled. We obtained 802 plasma samples collected serially. antibodies determined using four lateral flow...

10.2139/ssrn.3897696 article EN SSRN Electronic Journal 2021-01-01
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