A5042067089- HIV-related health complications and treatments
- HIV Research and Treatment
- HIV/AIDS Research and Interventions
- Sex work and related issues
- Health and Medical Studies
- Pneumocystis jirovecii pneumonia detection and treatment
- Adolescent Sexual and Reproductive Health
- Reproductive tract infections research
- Viral Infections and Immunology Research
- Poxvirus research and outbreaks
- Viral-associated cancers and disorders
- HIV/AIDS drug development and treatment
- Pericarditis and Cardiac Tamponade
- SARS-CoV-2 and COVID-19 Research
- Genital Health and Disease
- Skin Diseases and Diabetes
- Child and Adolescent Health
- Urological Disorders and Treatments
- Pharmaceutical studies and practices
- Dermatology and Skin Diseases
- Herpesvirus Infections and Treatments
- Lymphoma Diagnosis and Treatment
- Cervical Cancer and HPV Research
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Medicine and Dermatology Studies History
Ruhr University Bochum
2005-2025
Zero to Three
2022
University Hospitals of the Ruhr-University of Bochum
2011-2012
University of Duisburg-Essen
2010
Federal Ministry of Health
2010
Deutsche Gesellschaft für Information und Wissen
2010
GTx (United States)
2006
St. Josef-Hospital
2006
Urethritis is a common condition predominantly caused by sexually transmitted pathogens such as Chlamydia trachomatis, Neisseria gonorrhoeae, and Mycoplasma genitalium. It not possible to differentiate with certainty between on the basis of clinical characteristics alone. However, empirical antibiotic therapy often initiated in practice. The aim this practice guideline promote an evidence-based syndrome-orientated approach management male adolescents adults symptoms urethritis. Besides...
Purpose: Antiretroviral therapy has improved the prognosis for many individuals with HIV infection. Consequently, infection become a chronic and manageable disease increased risk of cardiovascular disease. Isolated diastolic dysfunction (DD) may be first indication underlying cardiac an early marker coronary artery Our aim was to assess prevalence DD in HIV-infected patients. Methods: In this cross-sectional cohort study, 698 unselected patients were included. All subjects underwent...
Zusammenfassung Die Urethritis ist ein häufiges, überwiegend durch sexuell übertragene Erreger wie Chlamydia trachomatis , Neisseria gonorrhoeae oder Mycoplasma genitalium verursachtes Krankheitsbild. Alleine aufgrund klinischer Merkmale die Unterscheidung der und Ausschluss von Koinfektionen nicht sicher möglich. In praktischen Versorgungssituation wird jedoch oftmals, noch vor dem Erregernachweis, eine empirische antibiotische Therapie durchgeführt. Ziel dieser evidenzbasierten S3‐Leitline...
Kaposi's sarcoma (KS) is a rare, malignant, multilocular vascular disease originating from lymphatic endothelial cells that can primarily affect the skin and mucous membranes, but also system internal organs such as gastrointestinal tract, lungs or liver. Five epidemiological subtypes of KS with variable clinical course prognosis are distinguished, increased incidence in specific populations: (1) Classical KS, (2) Iatrogenic immunosuppression, (3) Endemic (African) lymphadenopathic (4)...
Supplementation with uridine offers the possibility of a new and promising approach to nucleoside analogue reverse transcriptase inhibitor-associated mitochondrial toxicity. We investigated metabolic effects short-course treatment uridine-enriched food supplement NucleomaxX on hepatic function in thymidine-analogue treated HIV-infected patients. Mitochondrial was assessed by recently introduced non-invasive C-methionine breath test. supplementation enhanced decarboxylation reversibly but...
Abstract Purpose This study examined the characteristics, incidence and prognostic factors of first AIDS-defining condition developed after more than one year continuous antiretroviral therapy (ART) among people living with HIV (PLHIV). Methods We used data from two multicentre observational cohorts PLHIV in Germany between 1999 2018. Our outcome was event that occurred during follow-up ART. Descriptive analyses at ART initiation, time AIDS most frequently observed types illnesses were...
Abstract Human papillomavirus (HPV) XS2 was isolated from warts on an immunosuppressed patient. After HPV vaccination, the resolved. HPVXS2 also found in and normal skin of HIV-positive patients rarely HIV-negative controls. Further studies should elucidate mechanisms that lead to wart clearance.
HIV infection is associated with an elevated rate of cardiac diseases. The aim the current study was to assess prevalence valvular disorders in a large population HIV-infected patients.We enrolled 803 adults (age 44 ± 10 years, 16.6% women) this prospective, multicenter cohort study. All patients underwent comprehensive two-dimensional transthoracic echocardiography examination including Doppler evaluation function. Statistical analyses were performed respect severity infection.Overall,...
Traditional cardiovascular risk scores underestimate the incidence of diseases (CVD) in people living with HIV (PLH). This study compared effect HIV-specific factors (CRF) traditional CRF at baseline for their association incident CVD PLH. The ongoing, prospective HEART Aging (HIVH) assesses PLH German Ruhr Area since 2004. from HIVH least 5 years follow-up were examined help Cox proportional hazards models using inverse probability-of-censoring weights. adjusted age and sex. obtained hazard...
After the introduction of antiretroviral therapy, life expectancy HIV patients has increased to more than 30 years after initial diagnosis. Cardiovascular disease now is an important cause death in HIV-infected patients.In multicenter, prospective HIV-HEART study, 222 (38 %) suffered from lipodystrophy. Women were often affected men (41.5 % vs. 25.3 %). Patients with lipodystrophy on average 5 older and had been infected longer (10.4 6.6 years) then without lipodystrophy.Lipodystrophy was a...
Abstract Objectives Uncontrolled viral replication and antiretroviral treatment (ART) may independently contribute to hepatic mitochondrial toxicity. The present study was designed explore the longitudinal effects of modifications on function by means noninvasive 13C-methionine breath test (MeBT) diagnostics. Methods A total 113 HIV-infected patients underwent two consecutive MeBTs over an interval 11.8±3.5 months. Forty-nine remained stable ART or no therapy; 28 participants switched ART;...
Off-label use is defined as the usage of pharmaceuticals beyond their submitted, tested and approved use. Not only indications but also doses, route administration, patients' characteristics concomitant therapies are affected by approval. In recent years, impact off-label has increased markedly primarily because large number new medications with often limited dermatology, a multitude diagnoses exist which so uncommon that they have no chance approval studies. Experiences provide important...
Objectives: The aim of the study was to explore factors that may influence mental health status HIV-infected patients, and figure out a method could effectively classify patients by evaluating severity their problems. Methods: Eighty-five were recruited divided into two groups: low risk group (LRG, n = 38) high (HRG, 47). All finished Symptom Check-List 90 Revised (SCL-90-R) which is multidimensional questionnaire designed screen for broad range psychological Results: SCL-90-R scores HRG...