A5041824842- Cardiac Arrhythmias and Treatments
- Atrial Fibrillation Management and Outcomes
- HIV-related health complications and treatments
- Cardiac electrophysiology and arrhythmias
- Cardiac pacing and defibrillation studies
- Cardiovascular Function and Risk Factors
- Electrostatic Discharge in Electronics
- Cardiac Valve Diseases and Treatments
- Cardiovascular Syncope and Autonomic Disorders
- Cardiac Imaging and Diagnostics
- HIV Research and Treatment
- Viral Infections and Immunology Research
- Pneumocystis jirovecii pneumonia detection and treatment
- Cardiovascular Disease and Adiposity
- Healthcare Technology and Patient Monitoring
- HIV/AIDS drug development and treatment
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Heart Rate Variability and Autonomic Control
- Aortic aneurysm repair treatments
- Pulmonary Hypertension Research and Treatments
- Ion channel regulation and function
- Lipoproteins and Cardiovascular Health
- ECG Monitoring and Analysis
- Pericarditis and Cardiac Tamponade
- HIV/AIDS Research and Interventions
Witten/Herdecke University
2017-2025
Alfried Krupp Hospital
2016-2025
GTx (United States)
2018
Alfried Krupp von Bohlen und Halbach Foundation
2018
Essen University Hospital
2007-2014
West German Heart and Vascular Center Essen
2006-2013
Ruhr University Bochum
2013
University of Duisburg-Essen
2006-2012
Deutsches Herzzentrum München
2007-2011
Elisabeth-Krankenhaus Essen
2009
Pulsed field ablation (PFA) is a new, non-thermal modality for pulmonary vein (PV) isolation in patients with atrial fibrillation (AF). The multi-centre EUropean Real World Outcomes Field AblatiOn Patients Symptomatic AtRIAl Fibrillation (EU-PORIA) registry sought to determine the safety, efficacy, and learning curve characteristics pentaspline, multi-electrode PFA catheter.All-comer AF from seven high-volume centres were consecutively enrolled. Procedural follow-up data collected. Learning...
Macrolide antibiotics are known to have a different proarrhythmic potential in the presence of comparable QT prolongation surface ECG. Because extent has been used as surrogate marker for cardiotoxicity, we aimed study electrophysiological effects macrolide erythromycin, clarithromycin, and azithromycin previously developed experimental model proarrhythmia. In 37 Langendorff-perfused rabbit hearts, erythromycin (150-300 microM, n = 13) clarithromycin 13), 11) led similar increases interval...
Antiretroviral therapy improved the survival of patients with human immunodeficiency virus (HIV) infection. With increased life expectancy, HIV-infected increasingly are experiencing comorbidities, most notably cardiovascular risk factors (CRFs) and coronary heart disease (CHD). This study utilized a prospective, cross-sectional multicentre long-term design. In 803 (82% male; mean age 44.2 ± 10.3 years) we evaluated prevalence CRFs 10-year CHD using Framingham model. The presence factor was...
Abstract Aims Catheter ablation for atrial fibrillation (AF) using thermal energy can cause collateral damage. Pulsed field (PFA) is a novel non-thermal source. Few small clinical studies have been published. We report on the first ‘real-world’ experience with pulmonary vein isolation (PVI) PFA paroxysmal AF (PAF). Methods and results Pre- post-ablation, phrenic nerve function was assessed. After high-density left (LA) bipolar voltage mapping, all PVs were individually isolated 13 Fr...
Abstract Aims Pulsed field ablation (PFA) is a novel, non-thermal, cardiac tissue-selective modality. To date, radiofrequency (RF)-guided high-power short-duration (HPSD) represents the gold standard besides cryo-ablation for pulmonary vein isolation (PVI). This single-centre, retrospective study investigated efficacy of PFA-PVI vs. HPSD-RF PVI in terms single-procedure arrhythmia-free outcome and safety real-world setting. Methods results Consecutive, paroxysmal atrial fibrillation (AF)...
Purpose:To analyze aortic remodeling processes in terms of true (TL) and false lumen (FL) volumes patients with type B dissection undergoing thoracic endovascular repair (TEVAR) versus treated medically. Methods:Serial contrast-enhanced computed tomography (CT) scans 27 (24 men; mean age 60±13 years) who underwent TEVAR (n=17) or medical therapy only (n=10) were analyzed. TL FL over the entire descending aorta at baseline follow-up quantified by 3-dimensional reconstruction....
Thermal left atrial ablation can cause bronchial damage. Pulsed field (PFA) is a novel, nonthermal modality for paroxysmal fibrillation. We report on effects after pulmonary vein isolation using PFA fibrillation.A computed tomography scan showing the respiratory tract adjacent to was obtained. Oral anticoagulation interrupted procedure day. Peri-procedurally, patients received heparin with an activated clotting time goal of >350 seconds. All veins were individually isolated 13F steerable...
Congenital and acquired long QT syndrome (LQTS) are caused by abnormalities of ionic currents underlying ventricular repolarization. For a better understanding the mechanisms which functional electrical instability at level whole heart leads to torsade de pointes (TdP), novel model LQT3 was developed role transmural dispersion repolarization for development proarrhythmia evaluated.In 11 Langendorff-perfused rabbit hearts, veratridine (0.1-0.5 microM), an inhibitor sodium channel...
Purpose: Antiretroviral therapy has improved the prognosis for many individuals with HIV infection. Consequently, infection become a chronic and manageable disease increased risk of cardiovascular disease. Isolated diastolic dysfunction (DD) may be first indication underlying cardiac an early marker coronary artery Our aim was to assess prevalence DD in HIV-infected patients. Methods: In this cross-sectional cohort study, 698 unselected patients were included. All subjects underwent...
Human immunodeficiency virus (HIV) infection is an independent risk factor for coronary heart disease (CHD) and associated with perturbation of the gut microbiota.We analyzed microbiota in 30 HIV-infected individuals CHD (CHD+) without (CHD-) HIV-HEART study group.Gut linked to was lower α-diversity. Despite insignificant differences β-diversity, co-occurrence networks bacterial genera clearly diverged between CHD+ CHD- individuals. Multidimensional scaling separated into 2 microbiome...
Idiopathic pulmonary arterial hypertension (PAH) is a rare disease. HIV-infected patients exhibit considerably higher rate of development this condition compared to the general population.This cross-sectional study 802 (83.4% male; age 44.3+/-10.3 years) HIV-positive aimed evaluate male-to-female ratio in HIV-related PAH and elucidate whether more likely occur receiving highly active antiretroviral therapy (HAART) than HIV-treatment-naïve patients. All were examined by Doppler...
Background: Corrected QT (QTc) prolongation is predictive of cardiovascular mortality in both the general and human immunodeficiency virus (HIV) populations. Objective: As part HIV-HEART study, we assessed prevalence risk factors a prolonged QTc interval patients with HIV infection. Methods: In this cross-sectional cohort 802 unselected HIV-infected were included. Data analyzed by use gender-specific categories (men abnormal at > 440 ms women >460 ms). Multiple variables related to infection...