A5056482819- Chemotherapy-induced cardiotoxicity and mitigation
- Radiation Dose and Imaging
- Cardiac Imaging and Diagnostics
- Breast Cancer Treatment Studies
- Cardiac Arrhythmias and Treatments
- Cardiovascular Function and Risk Factors
- Cardiac pacing and defibrillation studies
- Atrial Fibrillation Management and Outcomes
- Advanced Radiotherapy Techniques
- Cardiac electrophysiology and arrhythmias
- Cancer Treatment and Pharmacology
- Ocular and Laser Science Research
- Radiation Therapy and Dosimetry
- Radioactivity and Radon Measurements
- Traumatic Ocular and Foreign Body Injuries
- Cardiac Valve Diseases and Treatments
- Effects of Radiation Exposure
- Carcinogens and Genotoxicity Assessment
- Acute Myocardial Infarction Research
- Radiology practices and education
- Brain Metastases and Treatment
- Intraocular Surgery and Lenses
- Cardiovascular Syncope and Autonomic Disorders
- Advanced X-ray and CT Imaging
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
Autorité de Sûreté Nucléaire
2025
Institut de Radioprotection et de Sûreté Nucléaire
2015-2024
Universitario Francisco de Asís
2024
Hepatitis B Foundation
2024
Laboratoire de Chimie Physique - Matière et Rayonnement
2009-2022
National Institute for Radiological Protection
2012-2021
Université de Caen Normandie
2019
Normandie Université
2019
Service de la Santé Publique
2017
Laboratoire Epidémiologie et Analyses en Santé Publique : Risques, Maladies Chroniques et Handicaps
2015
Epidemiologic studies of the prevalence rheumatic heart disease have used clinical screening with echocardiographic confirmation suspected cases. We hypothesized that all surveyed children would show a significantly higher disease.Randomly selected schoolchildren from 6 through 17 years age in Cambodia and Mozambique were screened for according to standard criteria.Clinical examination detected was confirmed by echocardiography 8 3677 5 2170 Mozambique; corresponding rates 95% confidence...
Intra-individual heterogeneity of cardiac exposure is an issue in breast cancer (BC) radiotherapy that was poorly considered previous cardiotoxicity studies mainly based on mean heart dose (MHD). This dosimetric study analyzes the distribution individually-determined radiation doses to and its substructures including coronary arteries evaluate whether MHD a relevant surrogate parameter for these substructures.Data were collected from BACCARAT prospective included left or right unilateral BC...
The choice of resynchronization therapy between with (CRT-D) and without (CRT-P) a defibrillator remains contentious issue. Cause-of-death analysis among CRT-P, compared CRT-D, patients could help evaluate the extent to which CRT-P would have additionally benefited from in daily clinical practice.A total 1705 consecutive implanted CRT (CRT-P: 535 CRT-D: 1170) 2008 2010 were enrolled CeRtiTuDe, multicentric prospective follow-up cohort study, specific adjudication for causes death at 2 years....
Abstract Aims The aim of this study was to compare procedural efficacy and safety, including 1-year freedom from AF recurrence, between the novel cryoballoon system PolarX (Boston Scientific) Arctic Front Advance Pro (AFA-Pro) (Medtronic), in patients with paroxysmal undergoing PVI. Methods results This multicentre prospective observational included 267 consecutive a first cryoablation procedure for (137 PolarX, 130 AFA-Pro). Kaplan-Meier curves log-rank test used recurrence both groups....
The increasing use of CT scans in the paediatric population raises question a possible health impact ionising radiation exposure associated with scans. aim this study was to describe pattern early childhood.In 14 major French radiology departments, children undergoing at least 1 scan before age 5, between 2000 and 2006, were included. For each examination, absorbed organ doses calculated.43% 27 362 cohort aged less than year during their first exposure, 9% being month. mean number...
Radiation dose to the eye lens is a crucial issue for interventional cardiologists (ICs) who are exposed during procedures they perform. This paper presents retrospective assessment of cumulative doses ICs enrolled in O'CLOC study Occupational Cataracts and Lens Opacities Cardiology. Information on workload catheterisation laboratory, radiation protection equipment, per procedure reduction factors associated with eye-protective equipment were considered. For 129 at an average age 51 had...
Radiotherapy (RT) for breast cancer presents a benefit in terms of reducing local recurrence and deaths resulting from but it can lead to secondary effects due the presence neighboring cardiac normal tissues within irradiation field. Breast RT has been shown be associated with long-term increased risk heart failure, coronary artery disease, myocardial infarction finally cardiovascular death more than 10 years after RT. However, there is still lack knowledge early cardiotoxicity induced by...
Previous studies suggested that radiation therapy (RT) for breast cancer (BC) can induce cardiac arrhythmias and conduction disorders. However, the association with mean heart dose specific substructures doses was less studied.We conducted a nested case-control study based on French BC patients, enrolled in European MEDIRAD-BRACE (https://clinicaltrials.gov, Identifier: NCT03211442), who underwent three-dimensional conformal (3D-CRT) between 2009 2013 were retrospectively followed until...
This paper presents the dosimetry part of European ELDO project, funded by DoReMi Network Excellence, in which a method was developed to estimate cumulative eye lens doses for past practices based on personal dose equivalent values, H(p)(10), measured above lead apron at several positions collar, chest and waist levels. Measurement campaigns anthropomorphic phantoms were carried out typical interventional settings considering different tube projections configurations, beam energies...
Abstract Background Breast cancer (BC) radiotherapy (RT) can induce cardiotoxicity, with adverse events often observed many years after BC RT. Subclinical left ventricular (LV) dysfunction be detected early RT global longitudinal strain (GLS) measurement based on 2D speckle-tracking echocardiography. This 6-month follow-up analysis from the BACCARAT prospective study aimed to investigate association between cardiac radiation doses and subclinical LV GLS reduction. Methods The patient group...
Higher cardiac radiation doses in participants with breast cancer treated therapy after lumpectomy were associated increased risk of reduced left ventricular global longitudinal strain at 2-year follow-up MRI.
Background Circadian disruption has long been appreciated as a downstream consequence of Alzheimer's Disease in humans. However, an upstream role for behavioral circadian regulating AD pathology remains open question. Methods To determine the central clock suprachiasmatic nucleus (SCN) amyloid pathology, we crossed 5xFAD mouse model with mice harboring deletion critical gene Bmal1 GABAergic neurons using VGAT-iCre, which is expressed >95% SCN cells. examine light-dark cycle this process,...
Right-lateralized cardiac substructures can be substantially exposed during right breast cancer (R-BC) radiotherapy. The benefit of deep inspiration breath hold (DIBH) is established in combination with volumetric modulated arctherapy (VMAT) for left regional node irradiation but unknown R-BC. This study evaluated the dosimetric DIBH locoregional R-BC VMAT.All patients treated adjuvant DIBH-VMAT Department Radiation Oncology Institut Curie (Paris, France) until December 2022 were included,...
The eye is well known to be sensitive clearly high doses (>2 Gy) of ionizing radiation. In recent years, however, cataracts have been observed in populations exposed lower doses. Interventional cardiologists are repeatedly and acutely scattered radiation (X-rays) during the diagnostic therapeutic procedures they perform. These "low" exposures may cause damage lens induce early cataracts, as radiation-induced cataracts. O'CLOC study (Occupational Cataracts Lens Opacities interventional...
Purpose: We measured the proportion of intravascular leads, which can be extracted by simple traction versus with newer techniques, and examined overall safety success rate lead extractions. Methods: Between January 2005 December 2007, 311 consecutive patients (mean age = 70 ± 14 years, 79% men) underwent extractions 250 atrial, 318 ventricular, 22 coronary sinus in surgical facilities two experienced medical centers, under general anesthesia, at a mean 7.2 5.1 years (range 0.1–27.0) after...
<h3>Objectives</h3> Increased risk of circulatory system diseases (CSDs) was observed in nuclear workers handling uranium and plutonium Russia the UK. This work examines CSD mortality after chronic intake among 2897 (79 892 person-years) at a processing plant (1960–2006) France. <h3>Methods</h3> Cumulative exposure to different compounds, classified by their isotopic composition solubility type, quantified on basis plant-specific job-exposure matrix individual job histories. HRs associated...
Breast cancer is the most common among women, and radiotherapy plays a major role in its treatment. However, breast can lead to incidental irradiation of heart, resulting an increased risk for variety heart diseases arising many years after radiotherapy. Therefore, identifying patients at highest radiation-induced cardiac complications crucial developing strategies primary secondary prevention, which may contribute healthy aging. There still need precise knowledge on relationship between...