A5039736453- Cardiovascular Function and Risk Factors
- Cardiac Imaging and Diagnostics
- Advanced MRI Techniques and Applications
- Cardiac Valve Diseases and Treatments
- Atrial Fibrillation Management and Outcomes
- Cardiac Arrhythmias and Treatments
- Historical and Scientific Studies
- Cardiovascular Effects of Exercise
- Viral Infections and Immunology Research
- Advanced X-ray and CT Imaging
- Pulmonary Hypertension Research and Treatments
- Cardiomyopathy and Myosin Studies
- Cardiovascular Disease and Adiposity
- Radiomics and Machine Learning in Medical Imaging
- Congenital Heart Disease Studies
- Transcranial Magnetic Stimulation Studies
- Sports injuries and prevention
- Chemotherapy-induced cardiotoxicity and mitigation
- Heart Rate Variability and Autonomic Control
- Pain Mechanisms and Treatments
- Cardiac pacing and defibrillation studies
- Inflammatory Myopathies and Dermatomyositis
- Psychoanalysis and Psychopathology Research
- Motor Control and Adaptation
- Advanced MEMS and NEMS Technologies
Paris Cardiovascular Research Center
2023-2025
Sorbonne Université
2005-2024
Laboratoire d’Imagerie Biomédicale
2015-2024
Université Paris Cité
2011-2024
Inserm
2005-2024
Yale University
2021-2024
Assistance Publique – Hôpitaux de Paris
2023-2024
Hôpital Européen Georges-Pompidou
2024
Centre National de la Recherche Scientifique
2011-2024
Favaloro University
2024
Left atrial (LA) imaging is still not routinely used for diagnosis and risk stratification, although recent studies have emphasized its importance as an biomarker. Cardiovascular magnetic resonance able to evaluate LA structure function, metrics that serve early indicators of disease, provide prognostic information, e.g. regarding diastolic dysfunction, fibrillation (AF). MR angiography defines anatomy, useful planning ablation procedures, also characterizing shapes sizes might predict...
Left atrium (LA) volumes and function are predictors of cardiovascular events. Because LA cannot be assessed from magnetic resonance imaging (MRI) using the well-established left ventricular tagging techniques, we hypothesized that adequate feature tracking (FT) applied to conventional cine MRI data could characterize accurately.We studied 10 young (28 ± 7 years) elderly (64 6 healthy subjects, as well 20 patients with moderate severe aortic valve stenosis (AVS; 73 15 years, effective area:...
Importance of left atrial (LA) phasic function evaluation is increasingly recognized for its incremental value in terms prognosis and risk stratification. LA deformation the pathway normal aging has been characterized using echocardiographic speckle tracking. However, no data are available regarding age-related variations feature-racking (FT) techniques from standard cine magnetic resonance imaging (MRI). We studied 94 healthy adults (41 ± 14 yr, 47 women), who underwent MRI Doppler...
Higher cardiac radiation doses in participants with breast cancer treated therapy after lumpectomy were associated increased risk of reduced left ventricular global longitudinal strain at 2-year follow-up MRI.
Idiopathic inflammatory myopathy (IIM) is a group of autoimmune diseases with systemic myositis which may involve the myocardium. Cardiac involvement in IIM, although often subclinical, mimic clinical manifestations acute viral myocarditis (AVM). Our aim was to investigate usefulness combined analysis cardiovascular magnetic resonance (CMR) T1 and T2 mapping parameters measured both myocardium thoracic skeletal muscles differentiate AVM from IIM cardiac involvement. Sixty subjects were...
Purpose To determine whether left atrial (LA) strain quantification with cardiac magnetic resonance (MR) imaging feature tracking is associated the severity of LA fibrofatty myocardial remodeling at histologic analysis. Materials and Methods This prospective case-control study was approved by institutional review board. evaluated MR between January 2014 March 2015 in 13 consecutive patients (mean age, 61 years ± 19; nine male) mitral regurgitation 24 hours before valve surgery age-...
Immune checkpoint inhibitors (ICIs) are highly effective in treating cancer; however, cardiotoxicity can occur, including myocarditis. Cardiac magnetic resonance (CMR) imaging is useful for evaluation of myocarditis, although it has not been well studied ICI cardiotoxicity.We identified patients referred CMR from September 2015 through 2019. We assessed structural and functional parameters, feature tracking (FT) left ventricular atrial strain, T2- weighted ratios quantitative late gadolinium...
Abstract Background Diastolic dysfunction is a major cause of morbidity in obese individuals. We aimed to assess the ability magnetic resonance imaging (MRI) derived left atrial (LA) strain detect early diastolic individuals with obesity and type 2 diabetes, explore association between cardiac adipose tissue LA function. Methods Twenty patients T2D (55 ± 8 years) nineteen healthy controls (48 13 were imaged using cine steady state free precession 2-point Dixon cardiovascular resonance....
Purpose To investigate whether the peak early filling rate normalized to volume (PEFR/FV) estimated from four-dimensional (4D) flow cardiac MRI may be used assess impaired left ventricular (LV) and predict clinical outcomes in individuals with hypertrophic cardiomyopathy (HCM). Materials Methods Cardiac a 4D sequence late gadolinium enhancement (LGE), as well echocardiography, was performed 88 individuals: 44 participants HCM French prospective registry (ClinicalTrials.gov; NCT01091480)...
Segmentation of the left atrium (LA) is required to evaluate atrial size and function, which are important imaging biomarkers for a wide range cardiovascular conditions, such as fibrillation, stroke, diastolic dysfunction. LA segmentations currently being performed manually, time-consuming observer-dependent.
The vestibular responses evoked by transmastoid galvanic stimulation (GS) in the rectified soleus electromyogram (EMG) freely standing human subjects disappear when seated. However, a GS-induced facilitation of monosynaptic (H and tendon jerk) reflex has been described few experiments lying prone or This study addresses issue whether this while seated is vestibulospinal origin. (modulation ongoing EMG reflexes) were compared same normal sitting with back head support. polarity-dependent...
OBJECTIVE. The purpose of this study was to test the hypothesis that patients with idiopathic dilated cardiomyopathy (IDCM) and heart failure have increased liver T1 relaxation times at MRI owing congestion compared in IDCM without healthy control subjects. MATERIALS AND METHODS. For retrospective cross-sectional study, 55 subjects (33 men, 22 women; mean age, 47 ± 15 years) who had undergone cardiac were included: 20 35 consecutively registered IDCM. Twenty-one hospitalized for acute...
Mitral annular plane systolic excursion (MAPSE) and left ventricular (LV) early diastolic velocity (e') are key metrics of function, but not often measured by cardiovascular magnetic resonance (CMR). Its derivation is possible with manual, precise annotation the mitral valve (MV) insertion points along cardiac cycle in both two four-chamber long-axis cines, this process highly time-consuming, laborious, prone to errors. A fully automated, consistent, fast, accurate method for MV tracking...
Abstract Purpose Tricuspid valve flow velocities are challenging to measure with cardiovascular MR, as the rapidly moving valvular plane prohibits direct evaluation, but they vitally important diastolic function evaluation. We developed an automated valve‐tracking 2D method for measuring through dynamic tricuspid valve. Methods Nine healthy subjects and 2 patients were imaged. The approach uses a previously trained deep learning network, TVnet, automatically track from long‐axis cine images....
Adverse effects of large artery stiffening are well established in the systemic circulation; proximal pulmonary (PPA) and its sequelae poorly understood. We combined vivo (n = 6) with ex data from cadavers 8) organ donors 13), ages 18 to 89, assess whether aging PPA associates changes distensibility, biaxial wall strain, thickness, vessel diameter, composition. Aging exhibited significant negative associations distensibility cyclic strain (p ≤ 0.05), decreasing circumferential axial strains...
Abstract Transthoracic echocardiography (TTE) is the first‐line and most useful imaging modality for evaluating diastolic dysfunction (DD). Cardiovascular magnetic resonance (CMR) has not been fully evaluated this task. We investigated utility of CMR DD evaluation.Thirty‐one patients with a recent TTE (within 4 months) were prospectively enrolled, along 12 healthy age‐matched subjects. was performed at 1.5 T to assess function by quantifying mitral inflow velocities (E A), annular (e’), left...