A5058575753- Chemotherapy-induced cardiotoxicity and mitigation
- Cardiac Imaging and Diagnostics
- Breast Cancer Treatment Studies
- Advanced Radiotherapy Techniques
- Cardiovascular Function and Risk Factors
- Medical Imaging Techniques and Applications
- Ovarian cancer diagnosis and treatment
- Radiation Dose and Imaging
- Cancer Risks and Factors
- Radiomics and Machine Learning in Medical Imaging
- Pancreatic and Hepatic Oncology Research
- Cancer-related Molecular Pathways
- Global Cancer Incidence and Screening
- Cancer-related cognitive impairment studies
- PI3K/AKT/mTOR signaling in cancer
- Lymphoma Diagnosis and Treatment
- Cardiovascular Disease and Adiposity
- Radiation Therapy and Dosimetry
- Cutaneous lymphoproliferative disorders research
- Cancer, Lipids, and Metabolism
- Endometrial and Cervical Cancer Treatments
- HER2/EGFR in Cancer Research
- Effects of Radiation Exposure
- Digital Radiography and Breast Imaging
- Gene expression and cancer classification
University of Groningen
2016-2025
University Medical Center Groningen
2016-2025
AbbVie (Bahamas)
2017
Siemens (Germany)
2017
Roche (Bosnia-Herzegovina)
2017
Purpose A relationship between mean heart dose (MHD) and acute coronary event (ACE) rate was reported in a study of patients with breast cancer (BC). The main objective our cohort to validate this investigate if other dose-distribution parameters are better predictors for ACEs than MHD. Patients Methods consisted 910 consecutive female BC treated radiotherapy (RT) after breast-conserving surgery. primary end point cumulative incidence within 9 years follow-up. Both MHD various the cardiac...
PurposePencil beam scanned proton therapy (PBS-PT) treatment quality might be compromised by interplay and motion effects. Via fraction-wise reconstruction of 4D dose distributions accumulation, we assess the clinical relevance related target degradation in thoracic cancer patients.Methods materialsFor ten patients (Hodgkin lymphoma non-small cell lung cancer) treated at our facility, daily breathing pattern records, delivery log-files weekly repeated 4DCTs were collected. Patients exhibited...
Previous studies suggested that radiation therapy (RT) for breast cancer (BC) can induce cardiac arrhythmias and conduction disorders. However, the association with mean heart dose specific substructures doses was less studied.We conducted a nested case-control study based on French BC patients, enrolled in European MEDIRAD-BRACE (https://clinicaltrials.gov, Identifier: NCT03211442), who underwent three-dimensional conformal (3D-CRT) between 2009 2013 were retrospectively followed until...
Abstract Purpose: To evaluate if serum cytokine levels could be used as diagnostic or prognostic markers in ovarian cancer. Experimental Design: A bead array was done to simultaneously analyze 14 cytokines the sera of 187 cancer patients with complete clinicopathologic data and follow-up, 45 benign tumors, 50 healthy controls. Serum well-known tumor marker CA-125 were routinely measured all patients. Results: CA-125, interleukin 6 (IL-6), IL-7, IL-10 elevated compared tumors. Analyzing...
Ovarian cancer is the most frequent cause of death from gynaecological in Western world. Current prognostic factors do not allow reliable prediction response to chemotherapy and survival for individual ovarian patients. Epidermal growth factor receptor (EGFR) HER-2/neu are frequently expressed but their value remains unclear. In this study, we investigated expression EGFR, EGFR variant III (EGFRvIII), important downstream signalling components a large series epithelial Immunohistochemical...
PurposeRadiation-induced acute coronary events (ACEs) may occur as a treatment-related late adverse effect of breast cancer (BC) radiation. However, the underlying mechanisms behind this radiation-induced cardiac disease remain to be determined. The objective study was test hypothesis that radiation dose calcified atherosclerotic plaques in left anterior descending artery (LAD) is better predictor for ACEs than whole heart or ventricle patients with BC treated therapy.Methods and...
Anthracyclines increase heart failure (HF) risk, but the long-term prevalence of myocardial dysfunction in young breast cancer (BC) survivors is unknown. Early measures left ventricular are needed to identify BC patients at risk symptomatic HF.Within an established cohort, we studied markers for among 569 women, who were 5-7 years (n = 277) or 10-12 292) after treatment ages 40-50 years. Left ejection fraction (LVEF) and global longitudinal strain (GLS) assessed by echocardiography....
Breast cancer is the most common among women, and radiotherapy plays a major role in its treatment. However, breast can lead to incidental irradiation of heart, resulting an increased risk for variety heart diseases arising many years after radiotherapy. Therefore, identifying patients at highest radiation-induced cardiac complications crucial developing strategies primary secondary prevention, which may contribute healthy aging. There still need precise knowledge on relationship between...
In the case of breast cancer (BC), radiotherapy (RT) helps reduce locoregional recurrence and BC-related deaths but can lead to cardiotoxicity, resulting in an increased risk long-term major cardiovascular events. It is therefore primary importance early detect subclinical left ventricular (LV) dysfunction BC patients after RT determine dose-response relationships between cardiac doses these events.Within frame MEDIRAD European project (2017-2022), prospective multicenter EARLY-HEART study...
Higher cardiac radiation doses in participants with breast cancer treated therapy after lumpectomy were associated increased risk of reduced left ventricular global longitudinal strain at 2-year follow-up MRI.
The prognostic impact of p53 immunostaining in a large series tumours from epithelial ovarian cancer patients two-centre study was analysed. population (n=476) comprised retrospective 188 (Dutch cohort) and prospective 288 (Scottish enrolled clinical trials. P53 expression determined by immunohistochemistry on tissue microarrays. Association with progression-free survival (PFS) overall (OS) analysed univariate multivariate Cox regression analysis. Aberrant overexpression significantly...
To assess sinoatrial node (SAN) and atrioventricular (AVN) doses for breast cancer (BC) patients treated with 3D-CRT evaluate whether "large" cardiac structures (whole heart four chambers) would be relevant surrogates.This single center study was based on 116 BCE (56 left-sided, 60 right-sided) without respiratory gating strategies few IMN irradiations from 2009 to 2013. The heart, the left right ventricles (LV, RV), atria (LA, RA) were contoured using multi-atlases auto-segmentation. SAN...
Acute coronary events (ACEs) are considered the most important side effect of radiation therapy (RT) for breast cancer, but underlying mechanisms still have to be identified. Process-oriented models mathematically describe development disease and provide a link between subsequent risk. Here, this is exploited learn about from observed age-time patterns ACE risk.A process-oriented model atherosclerosis ACEs was applied contemporary cancer cohort 810 patients with measurements artery...
Abstract Cardiac structure contouring is a time consuming and tedious manual activity used for radiotherapeutic dose toxicity planning. We developed an automatic cardiac segmentation pipeline use in low-dose non-contrast planning CT based on deep learning algorithms small datasets. Fifty scans were retrospectively selected the whole heart, ventricles atria contoured. A two stage was trained 41 non contrast CTs, tuned with 3 validated 6 scans. In first stage, An InceptionResNetV2 network to...
Purpose/Objective: To compare half (H-arc)-vs.quarter-arc (Q-arc) VMAT simultaneously integrated boost (SIB) approach to further reduce normal breast tissue dose burden using hypofractionated whole irradiation.Materials and Methods: Fifty-eight patients were included in this study Pinnacle 9.6 (Philips, Best, NL).For the (PTV1) irradiation two tangential field-in-field beams used, while treating (PTV2) volume a single was applied.SIB optimized inverse SmartARC technique taking into account...