A5003306040- Coronary Interventions and Diagnostics
- Pulmonary Hypertension Research and Treatments
- Aortic Disease and Treatment Approaches
- Electrospun Nanofibers in Biomedical Applications
- Tissue Engineering and Regenerative Medicine
- Aortic aneurysm repair treatments
- Elasticity and Material Modeling
- Cardiovascular Health and Disease Prevention
- Congenital Heart Disease Studies
- Atherosclerosis and Cardiovascular Diseases
- Cardiac and Coronary Surgery Techniques
- Eicosanoids and Hypertension Pharmacology
- Nuclear Structure and Function
- Cardiovascular Function and Risk Factors
- RNA Research and Splicing
- Connective tissue disorders research
- Cardiac Valve Diseases and Treatments
- Cardiovascular Disease and Adiposity
- Congenital heart defects research
- Vascular Procedures and Complications
- Birth, Development, and Health
- Central Venous Catheters and Hemodialysis
- Renin-Angiotensin System Studies
- Cardiac Imaging and Diagnostics
- PARP inhibition in cancer therapy
Yale University
2018-2025
Iowa State University
2024-2025
University of New Haven
2021
University of California, San Diego
2013-2017
Stanford University
2016
Apollo Hospitals
2000
We developed a tissue-engineered vascular graft (TEVG) for use in children and present results of U.S. Food Drug Administration (FDA)-approved clinical trial evaluating this patients with single-ventricle cardiac anomalies. The TEVG was used as Fontan conduit to connect the inferior vena cava pulmonary artery, but high incidence narrowing manifested within first 6 months, which treated successfully angioplasty. To elucidate mechanisms underlying early stenosis, we data-informed,...
Tissue-engineered vascular grafts hold great promise in many clinical applications, especially pediatrics wherein growth potential is critical. A continuing challenge, however, identification of optimal scaffold parameters for promoting favorable neovessel development. In particular, given the countless design available, including those related to polymeric microstructure, material behavior, and degradation kinetics, number possible designs almost limitless. Advances computationally modeling...
Abstract Background Tissue-engineered vascular grafts (TEVGs) have the potential to advance surgical management of infants and children requiring congenital heart surgery by creating functional conduits with growth capacity. Methods Herein, we used an integrative computational-experimental approach elucidate natural history neovessel formation in a large animal preclinical model; combining vitro accelerated degradation study mechanical testing, implantation studies vivo imaging histology,...
In the field of congenital heart surgery, tissue-engineered vascular grafts (TEVGs) are a promising alternative to traditionally used synthetic grafts. Our group has pioneered use TEVGs as conduit between inferior vena cava and pulmonary arteries in Fontan operation. The natural history graft remodeling its effect on hemodynamic performance not been well characterized. this study, we provide detailed analysis first U.S. clinical trial evaluating treatment disease. We show two distinct phases...
Hypertension induces significant aortic remodelling, often adaptive but sometimes not. To identify immuno-mechanical mechanisms responsible for differential we studied thoracic aortas from 129S6/SvEvTac and C57BL/6 J mice before after continuous 14-day angiotensin II infusion, which elevated blood pressure similarly in both strains. Histological biomechanical assessments of excised vessels were similar at baseline, suggesting a common homeostatic set-point mean wall stress. Histology further...
Matrix metalloproteinase (MMP)-12 is highly expressed in abdominal aortic aneurysms and its elastolytic function has been implicated the pathogenesis. This concept challenged, however, by conflicting data. Here, we sought to revisit role of MMP-12 aneurysm.Apoe-/- Mmp12-/-/Apoe-/- mice were infused with Ang II (angiotensin). Expression neutrophil extracellular traps (NETs) markers complement component 3 (C3) levels evaluated immunostaining aortas surviving animals. Plasma components analyzed...
Hypertension and transient increases in blood pressure from extreme exertion are risk factors for aortic dissection patients with age-related vascular degeneration or inherited connective tissue disorders. Yet, a common experimental model of angiotensin II-induced aortopathy mice appears independent high as lesions do not occur response to an alternative vasoconstrictor, norepinephrine, prevented by co-treatment vasodilator, hydralazine. We investigated vasoconstrictor administration adult...
Abstract Hypoxemia impairs cardiopulmonary function. We investigated pulmonary artery remodeling in mice exposed to chronic hypoxia for up five weeks and quantified associated changes cardiac lung function, without or with subsequent normoxic recovery the absence presence of exercise pharmacological intervention. Hypoxia-induced stiffening proximal stemmed primarily from adventitial collagen, which resulted part altered inter-cellular signaling phenotypic mural smooth muscle cells...
Vein graft failure is a prevalent problem in vascular surgeries, including bypass grafting and arteriovenous fistula procedures which veins are subjected to severe changes pressure flow. Animal clinical studies provide significant insight, but understanding the complex underlying coupled mechanisms can be advanced using computational models. Towards this end, we propose new model of venous growth remodelling (G&R) based on constrained mixture theory. First, identify constitutive...
Local microstructural defects and insidious positive feedback lead to tortuous arteries that disrupt blood flow.
This study provides reference values for changes in mouse lung biomechanics from 2 to 23 wk of age. There are rapid developmental structure and function male female mice between the ages 3 8 wk. Male become noticeably heavier than at or about 5 We identified that differences normal measurements likely weight-based, not sex-based.
Radial artery deviation and reimplantation exhibits improved patency rates in both sexes is associated with hemodynamics a rat model.
Abstract Tissue engineered vascular grafts (TEVGs) using scaffolds fabricated from braided poly(glycolic acid) (PGA) fibers coated with poly(glycerol sebacate) (PGS) are developed. The approach relies on in vivo tissue engineering by which neotissue forms solely within the body after a scaffold has been implanted. Herein, impact of altering braid design and coating formation is investigated. Several combinations braiding parameters manufactured evaluated Beige mouse model infrarenal...
Vein maladaptation, leading to poor long-term patency, is a serious clinical problem in patients receiving coronary artery bypass grafts (CABGs) or undergoing related procedures that subject veins elevated blood flow and pressure. We propose computational model of venous adaptation altered pressure based on constrained mixture theory growth remodeling (G&R). identify constitutive parameters optimally match biaxial data from mouse vena cava, then numerically the vein conditions quantify...
Abstract Stenosis is the primary complication of current tissue-engineered vascular grafts used in pediatric congenital cardiac surgery. Murine models provide considerable insight into possible mechanisms underlying this situation, but they are not efficient for identifying optimal changes scaffold design or therapeutic strategies to prevent narrowing. In contrast, computational modeling promises enable time- and cost-efficient examinations factors leading Whereas past have been limited by...
Clinical trials have demonstrated that lonafarnib, a farnesyltransferase inhibitor, extends the lifespan in patients afflicted by Hutchinson-Gilford progeria syndrome, devastating condition accelerates many characteristics of aging and results premature death due to cardiovascular sequelae. The US Food Drug Administration approved Zokinvy (lonafarnib) November 2020 for treating these patients, yet detailed examination drug-associated effects on structure, properties, function has remained...