A5083771332- Cardiac Arrest and Resuscitation
- Mechanical Circulatory Support Devices
- Congenital Heart Disease Studies
- Respiratory Support and Mechanisms
- Neonatal Respiratory Health Research
- Transplantation: Methods and Outcomes
- Cardiac Structural Anomalies and Repair
- Cardiac, Anesthesia and Surgical Outcomes
- Acute Kidney Injury Research
- Hemodynamic Monitoring and Therapy
- Heart Failure Treatment and Management
- Trauma Management and Diagnosis
- Congenital Diaphragmatic Hernia Studies
- Cardiac Arrhythmias and Treatments
- Tracheal and airway disorders
- Trauma and Emergency Care Studies
- Aortic Disease and Treatment Approaches
- Central Venous Catheters and Hemodialysis
- Ultrasound in Clinical Applications
- Sepsis Diagnosis and Treatment
- Airway Management and Intubation Techniques
- Disaster Response and Management
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Traumatic Brain Injury and Neurovascular Disturbances
- Blood Coagulation and Thrombosis Mechanisms
The Ohio State University
2016-2025
Nationwide Children's Hospital
2016-2025
Grandview Medical Center
2023
Rainbow Babies & Children's Hospital
2022
Nationwide Mutual Insurance Company (United States)
2020
Creative Commons
2019
Weatherford College
2019
Princeton University
2018
Eunice Kennedy Shriver National Institute of Child Health and Human Development
2018
Mattel Children's Hospital
2018
Hyperglycemia in critical care populations has been shown to be a risk factor for increased morbidity and mortality. Minimal data exist postoperative pediatric cardiac patients. The goal of this study was determine whether hyperglycemia the period associated with or mortality.Retrospective chart review.Tertiary care, free-standing medical center dedicated intensive unit.We included 184 patients <1 yr age who underwent surgery requiring cardiopulmonary bypass from October 2002 August 2004....
On the basis of laboratory cardiopulmonary resuscitation (CPR) investigations and limited adult data demonstrating that survival depends on attaining adequate arterial diastolic blood pressure (DBP) during CPR, American Heart Association recommends using to guide pediatric CPR. However, evidence-based targets CPR remain an important knowledge gap for guidelines.
We developed a tissue-engineered vascular graft (TEVG) for use in children and present results of U.S. Food Drug Administration (FDA)-approved clinical trial evaluating this patients with single-ventricle cardiac anomalies. The TEVG was used as Fontan conduit to connect the inferior vena cava pulmonary artery, but high incidence narrowing manifested within first 6 months, which treated successfully angioplasty. To elucidate mechanisms underlying early stenosis, we data-informed,...
Approximately 40% of children who experience an in-hospital cardiac arrest survive to hospital discharge. Achieving threshold intra-arrest diastolic blood pressure (BP) targets during cardiopulmonary resuscitation (CPR) and systolic BP after the return circulation may be associated with improved outcomes.To evaluate effectiveness a bundled intervention comprising physiologically focused CPR training at point care structured clinical event debriefings.A parallel, hybrid stepped-wedge, cluster...
Abstract Advancements in congenital heart surgery have heightened the importance of durable biomaterials for adult survivors. Dystrophic calcification poses a significant risk to long-term viability prosthetic these procedures. Herein, we describe natural history most frequently used vascular conduits, expanded polytetrafluoroethylene grafts. Through retrospective clinical study and an ovine model, compare degree between tissue-engineered grafts Results indicate superior durability grafts,...
OBJECTIVES: Arterial diastolic blood pressure (DBP) greater than 25 mm Hg in infants and 30 children 1 year old during cardiopulmonary resuscitation (CPR) was associated with survival to hospital discharge one prospective study. We sought validate these potential hemodynamic targets a larger multicenter cohort. DESIGN: Prospective observational SETTING: Eighteen PICUs the ICU-RESUScitation trial from October 2016 March 2020. PATIENTS: Children less or equal 18 years CPR seconds invasive (BP)...
The objective of this study was to associate ventilation rates during in-hospital cardiopulmonary resuscitation with 1) arterial blood pressure and 2) survival outcomes.Prospective, multicenter observational study.Pediatric pediatric cardiac ICUs the Collaborative Pediatric Critical Care Research Network.Intubated children (≥ 37 wk gestation < 19 yr old) who received at least 1 minute resuscitation.None.Arterial rate (breaths/min) were manually extracted from line capnogram waveforms....
In the field of congenital heart surgery, tissue-engineered vascular grafts (TEVGs) are a promising alternative to traditionally used synthetic grafts. Our group has pioneered use TEVGs as conduit between inferior vena cava and pulmonary arteries in Fontan operation. The natural history graft remodeling its effect on hemodynamic performance not been well characterized. this study, we provide detailed analysis first U.S. clinical trial evaluating treatment disease. We show two distinct phases...
Abstract Background Epinephrine is provided during cardiopulmonary resuscitation (CPR) to increase systemic vascular resistance and generate higher diastolic blood pressure (DBP) improve coronary perfusion attain return of spontaneous circulation (ROSC). The DBP response epinephrine pediatric CPR its association with outcomes have not been well described. Thus, the objective this study was measure between change in after administration ROSC. Methods This a prospective multicenter children...
Background: It is difficult to clinically detect a new infection in patients with Mechanical Circulatory Support (MCS; including veno-arterial and veno-veno extracorporeal membrane oxygenation, ventricular assist devices). The prompt, accurate identification of utilizing plasma biomarkers could prompt earlier initiation antimicrobial agents may improve outcomes. Methods: We utilized ELISA evaluate novel biomarkers, soluble Triggering Receptor Expressed on Myeloid cells (sTREM-1) Presepsin,...
Objectives: The objective of this study was to compare survival outcomes and intra-arrest arterial blood pressures between children receiving cardiopulmonary resuscitation for bradycardia poor perfusion those with pulseless cardiac arrests. Design: Prospective, multicenter observational study. Setting: PICUs ICUs the Collaborative Pediatric Critical Care Research Network. Patients: Children (< 19 yr old) who received greater than or equal 1 minute invasive pressure monitoring in place....
To evaluate associations between sodium bicarbonate use and outcomes during pediatric in-hospital cardiac arrest (p-IHCA).Prespecified secondary analysis of a prospective, multicenter cluster randomized interventional trial.Eighteen participating ICUs the ICU-RESUScitation Project (NCT02837497).Children less than or equal to 18 years old greater 37 weeks post conceptual age who received chest compressions any duration from October 2016 March 2021.None.Child event characteristics, prearrest...
Trisomy 13 and 18 are associated with congenital heart disease. Cardiac palliation has been reported in the literature, but is not usually done this population. Thus, a multi-disciplinary team may experience controversy formulating care plan that includes cardiac intervention. Our objective was to determine differences recommendations for intervention population between physicians specializing pediatric critical care, neonatology, genetics. A web-based survey performed April 2007 August...
Abstract Limited data exist on ECMO at the time of LT x in children. The UNOS database was queried from 2000 to 2013 for pediatric lung transplant recipients (<18 yr) assess post‐transplant survival patients x. Of 587 with 17 ECMO, 585 were used univariate and Kaplan–Meier function analysis, 535 multivariate Cox models, 24 propensity score matching. Univariate ( HR = 1.777; 95% CI : 0.658, 4.803; p 0.257) (log‐rank test: chi‐square (df 1): 1.32, 0.250) analyses did not identify a...