A5086586885- Breast Cancer Treatment Studies
- Advanced Radiotherapy Techniques
- Inflammatory Bowel Disease
- CO2 Sequestration and Geologic Interactions
- Colorectal and Anal Carcinomas
- Microscopic Colitis
- Pancreatic and Hepatic Oncology Research
- Lung Cancer Diagnosis and Treatment
- Radioactive element chemistry and processing
- Reservoir Engineering and Simulation Methods
- Atmospheric and Environmental Gas Dynamics
- Histone Deacetylase Inhibitors Research
- Gastric Cancer Management and Outcomes
- Microbial Community Ecology and Physiology
- Gynecological conditions and treatments
- Hydraulic Fracturing and Reservoir Analysis
- Drilling and Well Engineering
- Cancer survivorship and care
- Management of metastatic bone disease
- Ubiquitin and proteasome pathways
- Palliative Care and End-of-Life Issues
- Groundwater flow and contamination studies
- Peptidase Inhibition and Analysis
- Gut microbiota and health
- Mycobacterium research and diagnosis
Royal North Shore Hospital
2018-2024
The University of Sydney
2012-2024
King's College Hospital NHS Foundation Trust
2021-2023
King's College London
2019-2023
Mater Health Services
2020-2022
Mater Misericordiae Hospital
2021-2022
Northern Sydney Local Health District
2021
Inova Fairfax Hospital
2020
Chris O’Brien Lifehouse
2015-2018
Royal Prince Alfred Hospital
2009-2018
Romidepsin is a structurally unique, potent class 1 selective histone deacetylase inhibitor. The primary objective of this international, pivotal, single-arm, phase II trial was to confirm the efficacy romidepsin in patients with relapsed or refractory peripheral T-cell lymphoma (PTCL).Patients who were at least one prior systemic therapy for whom failed received 14 mg/m(2) as 4-hour intravenous infusion on days 1, 8, and 15 every 28 days. end point rate complete response/unconfirmed...
Radiotherapy is essential to the treatment of most solid tumors and acquired or innate resistance this therapeutic modality a major clinical problem. Here we show that miR-139-5p potent modulator radiotherapy response in breast cancer via its regulation genes involved multiple DNA repair reactive oxygen species defense pathways. Treatment cells with mimic strongly synergized radiation both
ABSTRACT Iron-reducing enrichments were obtained from leachate ponds at the U.S. Borax Company in Boron, Calif. Based on partial small-subunit (SSU) rRNA gene sequences (approximately 500 nucleotides), six isolates shared 98.9% nucleotide identity. As a representative, isolate QYMF was selected for further analysis. could be grown with Fe(III)-citrate, Fe(III)-EDTA, Co(III)-EDTA, or Cr(VI) as electron acceptors, and yeast extract lactate serve donors. Growth during iron reduction occurred...
Subsurface amendments of slow-release substrates (e.g., emulsified vegetable oil [EVO]) are thought to be a pragmatic alternative using short-lived, labile for sustained uranium bioimmobilization within contaminated groundwater systems. Spatial and temporal dynamics subsurface microbial communities during EVO amendment unknown likely differ significantly from those populations stimulated by soluble substrates, such as ethanol acetate. In this study, one-time injection resulted in decreased U...
Treatment of Crohn's disease (CD) with biologics may alter progression, leading to fewer disease-related complications, but cost and adverse event profiles often limit their effective use. Tools identifying patients at high risk who would benefit the most from biologics, be valuable. Previous studies suggest that biomarkers aid in determining course CD. We aimed determine if combined serologic immune responses NOD2 genetic markers are associated CD complications. In this cross-sectional...
Microbial communities were characterized at contaminated sites that had elevated levels of nitrate, nickel, aluminum, and uranium (up to 690 mM, 310 microM, 42 30 respectively). The bacterial community structure based upon clonal libraries the SSU rRNA genes (screened clones = 876) was diverse background site, but three acidic samples decreased diversity majority closely related Azoarcus Pseudomonas species. Arthrobacter Novosphingobium sequences recovered from not sites, similar pseudomonad...
Human papillomavirus (HPV) causes most cases of anal cancers. In this study, we analyzed biopsy material from 112 patients with cancers in Australia for the presence HPV DNA by INNO LiPA genotyping assay. There were 82% (92) males and 18% (20) females. The mean age at diagnosis was significantly ( p = 0.006) younger (52.5 years) than females (66 years). HIV‐infected diagnosed a much earlier (48.2 HIV negative (56.3 0.05). detected 96.4% (108) cases. type 16 commonest, 75% (81) samples being...
Introduction Anal cancer in men who have sex with (MSM) living HIV is an important issue but there are no consistent guidelines for how to screen this cancer. In settings where screening anal cytology unavailable, regular examinations been proposed some their cost‐effectiveness unknown. Methods Our objective was estimate the of HIV‐positive MSM Australia using a probabilistic Markov model. Data sources were based on medical literature and clinical trial receiving annual examination...
Our purpose was to report outcomes of a novel palliative radiation therapy protocol that omits computed tomography simulation and prospectively collects electronic patient-reported (ePROs).Patients receiving extracranial, nonstereotactic, linear accelerator-based who met inclusion criteria (no mask-based immobilization diagnostic within 4 weeks) were eligible. Global pain scored with the 11-point numerical rating scale (NPRS). Patients coded as having osseous or soft tissue metastases...
Abstract Introduction Temporary tissue expanders with metallic ports for gradual saline injection are increasingly employed to facilitate breast reconstruction after post‐mastectomy radiotherapy ( PMRT ). Treatment beams therefore pass through a high‐density rare‐earth magnet. Measurements ex vivo suggest attenuation of dose the skin and chest wall at clinical risk relapse. The purpose study was quantify resulting reduction in , compared treatment planning system TPS Methods Sixteen patients...
Repository corticotropin injection (RCI) has regulatory approval for many indications, including symptomatic sarcoidosis. This large case series of patients with advanced sarcoidosis treated RCI describes patient characteristics, utilization patterns, concomitant therapies, and physicians' assessments treatment response.Patients ⩾18 years sarcoidosis, in the previous 36 months, who had completed a course or received ⩾6 months at time data collection were included.The study included 302 (mean...
Aim: To assess real-world occurrence of common clinical trial-reported adverse events (AE) among patients with recurrent ovarian cancer initiating niraparib 200 mg/day. Materials & methods: This retrospective observational study used physician-extracted anonymized medical record data eligible mg/day after platinum-based chemotherapy. Results: Of 153 patients, 57 (37%) experienced ≥1 the three most all-grade AEs within 3 months initiation: nausea (16%; grade 3/4: 2%), thrombocytopenia (14%;...
Supportive cancer care services, including acupuncture and Tai Chi Qigong (TQ), are offered to patients manage symptoms and/or treatment-related adverse effects improve quality of life during after standard care. Normal face-to-face TQ group services were suspended the coronavirus (COVID-19) pandemic reduce risk transmission infection meet social distancing restriction guidelines. This led a sudden shift from sessions telehealth in health system. We report patients' experiences as new...