A5068308552- Prostate Cancer Diagnosis and Treatment
- Advanced Radiotherapy Techniques
- Prostate Cancer Treatment and Research
- Medical Imaging Techniques and Applications
- Radiation Dose and Imaging
- Pancreatic and Hepatic Oncology Research
- Colorectal Cancer Surgical Treatments
- Radiation Therapy and Dosimetry
- Health Systems, Economic Evaluations, Quality of Life
- Radiopharmaceutical Chemistry and Applications
- Gastric Cancer Management and Outcomes
- Bladder and Urothelial Cancer Treatments
- Advances in Oncology and Radiotherapy
- Inflammatory Bowel Disease
- Radiomics and Machine Learning in Medical Imaging
- Colorectal and Anal Carcinomas
- Colorectal Cancer Screening and Detection
- Management of metastatic bone disease
- Lung Cancer Diagnosis and Treatment
- Urologic and reproductive health conditions
- Cancer survivorship and care
- Statistical Methods in Clinical Trials
- Ethics in Clinical Research
- Cancer Genomics and Diagnostics
- Palliative Care and End-of-Life Issues
Royal North Shore Hospital
2016-2025
The University of Sydney
2016-2025
Northern Sydney Local Health District
2015-2025
Gosford Hospital
2018-2024
Northern Cancer Institute
2012-2024
Royal Bolton Hospital
2022-2023
Central Coast Local Health District
2023
University of British Columbia
2023
University of Liverpool
2010-2022
Australian and New Zealand Intensive Care Society
2018-2022
In prostate cancer with biochemical failure after therapy, current imaging techniques have a low detection rate at the prostate-specific antigen (PSA) levels which targeted salvage therapy is effective. <sup>11</sup>C-choline and <sup>18</sup>F-fluoromethylcholine, though widely used, poor sensitivity PSA levels. <sup>68</sup>Ga-PSMA (Glu-NH-CO-NH-Lys-(Ahx)-[<sup>68</sup>Ga-<i>N,N</i>′-bis[2-hydroxy-5-(carboxyethyl)benzyl]ethylenediamine-<i>N,N</i>′-diacetic acid]) has shown promising...
<sup>68</sup>Ga-PSMA PET/CT scanning has been shown to be more sensitive than conventional imaging techniques in patients with prostate cancer. This prospective Australian multicenter study assessed whether affects management intent primary or recurrent <b>Methods:</b> Before undertaking PET imaging, referring medical specialists completed a questionnaire detailing relevant demographic and clinical data as well their proposed plan. A separate follow-up was after the scan results were...
To examine the detection rates of (68) Ga-PSMA-positron emission tomography (PET)/computed (CT) in patients with biochemical recurrence (BCR) after radical prostatectomy (RP), and also impact on their management.A total 300 consecutive prostate cancer (PCa) who underwent Ga-PSMA-PET/CT between February July 2015 were prospectively included Prostate Cancer Imaging (ProCan-I) database. For present analysis, we BCR (prostate-specific antigen [PSA] level ≥0.05 <1.0 ng/mL) RP, being considered...
Prostate-specific membrane antigen (PSMA) may be targeted for both diagnostic and therapeutic purposes in the management of prostate cancer (PCa). In preclinical models, androgen blockade (AB) increases expression PSMA hormone-sensitive castrate-resistant xenotypes. The aim this study was to evaluate effect AB treatment on <sup>68</sup>Ga-PSMA-11 PET imaging hormone-naive (luteinizing hormone-releasing hormone [LHRH] ± bicalutamide) men (enzalutamide or abiraterone) with metastatic PCa....
<sup>68</sup>Ga-PSMA (prostate-specific membrane antigen) PET/CT is increasingly used in men with prostate-specific antigen (PSA) failure after radical prostatectomy (RP) to triage those who will benefit from salvage radiation treatment (SRT). This study examines the value of PSMA-informed SRT improving outcomes context biochemical RP. <b>Methods:</b> We analyzed rising PSA RP readings between 0.05 and 1.0 ng/mL, considered eligible for at time PSMA. For each patient, clinical pathologic...
We report on the clinical process, quality assurance, and geometric dosimetric results of first implementation electromagnetic transponder-guided MLC tracking which occurred 28 November 2013 at Northern Sydney Cancer Centre.An transponder-based positioning system (Calypso) was modified to send target position output in-house-developed code, adjusts leaf positions optimally align treatment beam with real-time position. Clinical process assurance procedures were developed performed. The for a...
<sup>68</sup>Ga-labeled prostate-specific membrane antigen (PSMA) PET/CT is increasingly used in men with biochemical recurrence (BCR) after radical prostatectomy (RP), but its longer-term prognostic or predictive potential these unknown. The aim of this study was to evaluate the value PSMA PET for a 3-y freedom from progression (FFP) BCR RP undergoing salvage radiotherapy (sRT). <b>Methods:</b> This prospective multicenter enrolled 260 between 2015 and 2017. Eligible patients were referred...
Objectives To test the hypothesis that observation with early salvage radiotherapy ( SRT ) is not inferior to ‘standard’ treatment adjuvant RT ART respect biochemical failure in patients pT3 disease and/or positive surgical margins SMs after radical prostatectomy RP ). compare following secondary endpoints between two arms: patient‐reported outcomes, adverse events, failure‐free survival, overall disease‐specific time distant failure, local cost utility analysis, quality adjusted life years...
Abstract Background Intravenous [IV] infliximab is a well-established therapy for inflammatory bowel diseases [IBD] patients. A subcutaneous [SC] formulation of [CT-P13] has recently been shown to be as effective IV after two doses induction in randomised trial, but there are no data support elective switching patients on maintenance therapy. We aimed assess the effectiveness an programme SC CT-P13 treated with infliximab. Methods Patients established infliximab, who switched CT-P13, were...
Purpose: Kilovoltage intrafraction monitoring (KIM) is a real‐time image guidance method that uses widely available radiotherapy technology, i.e., gantry‐mounted x‐ray imager. The authors report on the geometric and dosimetric results of first patient treatment using KIM which occurred September 16, 2014. Methods: current prior 2D images to estimate 3D target position during cancer delivery. software was written process kilovoltage (kV) streamed from standard C‐arm linear accelerator with kV...
68Ga prostate-specific membrane antigen (PSMA) PET/CT is a new imaging technique that significantly more sensitive to prostate cancer lesions than other conventional modalities. Various benign and malignant neoplasms may also express PSMA show uptake on scan. We report case of 66-year-old man who had scan for restaging carcinoma. A PSMA-avid left femoral lymph node was identified. Subsequent biopsy confirmed the diagnosis follicular lymphoma. It important be aware this possibility avoid...
Studies have reported the effect of gender in context assessing predictors survival from colorectal cancer (CRC); however, few specifically addressed impact on clinical and pathological outcomes CRC. Appreciation disparities may assist implementation measures to address these differences, improve overall patients with CRC.The South Western Sydney Colorectal Tumour Group registry, which encompasses a population excess 800,000, prospectively collects data new Data 1997 2004 were collected,...