A5006944238- Prostate Cancer Treatment and Research
- Prostate Cancer Diagnosis and Treatment
- Urologic and reproductive health conditions
- Cancer, Lipids, and Metabolism
- Epigenetics and DNA Methylation
- Microbial Inactivation Methods
- Cancer Genomics and Diagnostics
- Bladder and Urothelial Cancer Treatments
- Radiomics and Machine Learning in Medical Imaging
- Radiopharmaceutical Chemistry and Applications
- MRI in cancer diagnosis
- Radiation Effects and Dosimetry
- Genital Health and Disease
- Colorectal Cancer Surgical Treatments
- Single-cell and spatial transcriptomics
- Cancer-related gene regulation
- Colorectal Cancer Screening and Detection
- Health Systems, Economic Evaluations, Quality of Life
- Cancer Cells and Metastasis
- Statistical Methods in Clinical Trials
- Pelvic floor disorders treatments
- Advanced Radiotherapy Techniques
- Urinary Bladder and Prostate Research
- Urinary and Genital Oncology Studies
- Medical Imaging Techniques and Applications
Prostate Cancer Foundation of Australia
2015-2025
Garvan Institute of Medical Research
2016-2025
St Vincent's Clinic
2016-2025
UNSW Sydney
2016-2025
St Vincent's Hospital Sydney
2016-2025
St Vincent's Hospital
2002-2025
St Vincent’s Private Hospital Sydney
2007-2024
The Kinghorn Cancer Centre
2014-2024
Saint Vincent's Catholic Medical Center
2001-2024
St. Vincent's Birmingham
2001-2024
In prostate cancer with biochemical failure after therapy, current imaging techniques have a low detection rate at the prostate-specific antigen (PSA) levels which targeted salvage therapy is effective. <sup>11</sup>C-choline and <sup>18</sup>F-fluoromethylcholine, though widely used, poor sensitivity PSA levels. <sup>68</sup>Ga-PSMA (Glu-NH-CO-NH-Lys-(Ahx)-[<sup>68</sup>Ga-<i>N,N</i>′-bis[2-hydroxy-5-(carboxyethyl)benzyl]ethylenediamine-<i>N,N</i>′-diacetic acid]) has shown promising...
We developed a preoperative nomogram for prediction of lymph node metastases in patients with clinically localized prostate cancer.The study was retrospective, nonrandomized analysis 7,014 treated radical prostatectomy at 6 institutions between 1985 and 2000. Exclusion criteria consisted androgen ablation therapy, salvage pretreatment specific antigen (PSA) greater than 50 ng/ml. Preoperative predictors PSA, clinical stage (1992 TNM) biopsy Gleason sum. These were used logistic regression...
<sup>68</sup>Ga-PSMA PET/CT scanning has been shown to be more sensitive than conventional imaging techniques in patients with prostate cancer. This prospective Australian multicenter study assessed whether affects management intent primary or recurrent <b>Methods:</b> Before undertaking PET imaging, referring medical specialists completed a questionnaire detailing relevant demographic and clinical data as well their proposed plan. A separate follow-up was after the scan results were...
To assess the accuracy of 68Gallium-prostate-specific membrane antigen (68Ga-PSMA) positron emission tomography/computed tomography (PET/CT) for lymph node (LN) staging in intermediate- and high-risk prostate cancer (PCa).From April to October 2015, 30 patients with (n = 3) or 27) PCa were prospectively enrolled. Patients underwent preoperative 68Ga-PSMA PET/CT. Both visual semi-quantitative analyses undertaken. Subsequently, all radical prostatectomy (RP) an extended pelvic dissection. The...
Nicotine is thought to be the key substance responsible for tobacco-smoking habits and appears trigger reinforcement via ventral tegmental area (VTA). Recently, multiple anatomical substrates drug have been identified in vicinity of midbrain. In addition posterior portion VTA, central linear nucleus raphé supramammillary hypothalamus mediate reinforcement. Using intracranial self-administration procedures, we examined whether these regions reinforcing effects nicotine. Rats learned lever...
To examine the detection rates of (68) Ga-PSMA-positron emission tomography (PET)/computed (CT) in patients with biochemical recurrence (BCR) after radical prostatectomy (RP), and also impact on their management.A total 300 consecutive prostate cancer (PCa) who underwent Ga-PSMA-PET/CT between February July 2015 were prospectively included Prostate Cancer Imaging (ProCan-I) database. For present analysis, we BCR (prostate-specific antigen [PSA] level ≥0.05 <1.0 ng/mL) RP, being considered...
Multiparametric magnetic resonance imaging appears to improve prostate cancer detection but prospective studies are lacking. We determined the accuracy of multiparametric for detecting significant before diagnostic biopsy in men with abnormal specific antigen/digital rectal examination.In this single center, study older than 40 years examination and no previous underwent T2-weighted, diffusion-weighted dynamic contrast enhanced without an endorectal coil. Imaging was allocated alternately...
Prostate-specific membrane antigen (PSMA) may be targeted for both diagnostic and therapeutic purposes in the management of prostate cancer (PCa). In preclinical models, androgen blockade (AB) increases expression PSMA hormone-sensitive castrate-resistant xenotypes. The aim this study was to evaluate effect AB treatment on <sup>68</sup>Ga-PSMA-11 PET imaging hormone-naive (luteinizing hormone-releasing hormone [LHRH] ± bicalutamide) men (enzalutamide or abiraterone) with metastatic PCa....
<b>Background:</b> Multi-parametric magnetic resonance imaging (mpMRI) is validated for the diagnosis of clinically significant prostate cancer (csPCa). <sup>68</sup>Ga-PSMA -11 PET/CT (PSMA-PET/CT) combined with mpMRI has improved negative predictive value over alone csPCa. The aim this post-hoc analysis PRIMARY study was to evaluate clinical significance patterns intra-prostatic PSMA activity, proposing a 5- point score optimise accuracy PSMA-PET/CT csPCa in low prevalence population....
PURPOSE: We evaluated the predictive accuracy of a recently published preoperative nomogram for prostate cancer that predicts 5-year freedom from recurrence. applied this to patients seven different institutions spanning three continents. METHODS: Clinical data 6,754 were supplied validation, and 6,232 complete records used. Nomogram-predicted probabilities 60-month recurrence compared with actual follow-up in two ways. First, areas under receiver operating characteristic curves (AUCs)...
<sup>68</sup>Ga-PSMA (prostate-specific membrane antigen) PET/CT is increasingly used in men with prostate-specific antigen (PSA) failure after radical prostatectomy (RP) to triage those who will benefit from salvage radiation treatment (SRT). This study examines the value of PSMA-informed SRT improving outcomes context biochemical RP. <b>Methods:</b> We analyzed rising PSA RP readings between 0.05 and 1.0 ng/mL, considered eligible for at time PSMA. For each patient, clinical pathologic...
No AccessJournal of UrologyAdult Urology1 May 2016The Diagnostic Performance Multiparametric Magnetic Resonance Imaging to Detect Significant Prostate Cancer J.E. Thompson, P.J. van Leeuwen, D. Moses, R. Shnier, P. Brenner, W. Delprado, M. Pulbrook, Böhm, A.M. Haynes, A. Hayen, and P.D. Stricker ThompsonJ.E. Thompson St. Vincent’s Centre, Darlinghurst, New South Wales, Australia Garvan Institute Medical Research, Kinghorn School Medicine, University Kensington, More articles by this author ,...
Abstract Background: Epigenetic alterations are common in prostate cancer, yet how these modifications contribute to carcinogenesis is poorly understood. We investigated whether specific histone prognostic for cancer relapse, and the expression of epigenetic genes altered tumorigenesis. Methods: Global levels H3 lysine-18 acetylation (H3K18Ac) lysine-4 dimethylation (H3K4diMe) were assessed immunohistochemically a cohort 279 cases. gene was silico by analysis microarray data from 23 primary...
To evaluate in a multi-institutional study whether radiomic features useful for prostate cancer (PCa) detection from 3 Tesla (T) multi-parametric MRI (mpMRI) the transition zone (TZ) differ those peripheral (PZ).3T mpMRI, including T2-weighted (T2w), apparent diffusion coefficient (ADC) maps, and dynamic contrast-enhanced (DCE-MRI), were retrospectively obtained 80 patients at three institutions. This was approved by institutional review board of each participating institution. First-order...