A5088342842- Bladder and Urothelial Cancer Treatments
- Prostate Cancer Diagnosis and Treatment
- Prostate Cancer Treatment and Research
- Urinary and Genital Oncology Studies
- Radiomics and Machine Learning in Medical Imaging
- Urological Disorders and Treatments
- Urologic and reproductive health conditions
- MRI in cancer diagnosis
- Urinary Bladder and Prostate Research
- Fibroblast Growth Factor Research
- Renal cell carcinoma treatment
- Epigenetics and DNA Methylation
- Tissue Engineering and Regenerative Medicine
- Molecular Biology Techniques and Applications
- Cancer, Lipids, and Metabolism
- Radiopharmaceutical Chemistry and Applications
- Global Cancer Incidence and Screening
- Colorectal Cancer Screening and Detection
- Testicular diseases and treatments
- Hormonal and reproductive studies
- Cancer Cells and Metastasis
- Esophageal Cancer Research and Treatment
- Urinary Tract Infections Management
- Medical Imaging Techniques and Applications
- Advanced MRI Techniques and Applications
Turku University Hospital
2016-2025
University of Turku
2016-2025
Princess Margaret Cancer Centre
2009-2024
University Health Network
2010-2024
University of Toronto
2009-2024
Wesley Research Institute
2019
Health Net
2011-2017
Mount Sinai Hospital
2010-2014
Erasmus University Rotterdam
2012
Helsinki University Hospital
2012
Purpose Multidisciplinary management improves complex treatment decision making in cancer care, but its impact for bladder (BC) has not been documented. Although radical cystectomy (RC) currently is viewed as the standard of care muscle-invasive (MIBC), radiotherapy-based, bladder-sparing trimodal therapy (TMT) that combines transurethral resection tumor, chemotherapy radiation sensitization, and external beam radiotherapy emerged a valid option. In absence randomized studies, this study...
The first interim analysis of the KEYNOTE-564 study showed improved disease-free survival with adjuvant pembrolizumab compared placebo after surgery in patients clear cell renal carcinoma at an increased risk recurrence. reported here, additional 6 months follow-up, was designed to assess longer-term efficacy and safety versus placebo, as well secondary exploratory endpoints.In multicentre, randomised, double-blind, placebo-controlled, phase 3 trial, adults aged 18 years or older recurrence...
Radiohybrid (rh)
To evaluate variant histologies (VHs) for disease-specific survival (DSS) in patients with invasive urothelial bladder cancer (BCa) undergoing radical cystectomy (RC).We analysed a multi-institutional cohort of 1082 treated upfront RC cT1-4aN0M0 BCa at eight centres. Univariable and multivariable Cox' regression analyses were used to assess the effect different VHs on DSS overall three stage-based analyses. The stages defined as 'organ-confined' (≤pT2N0), 'locally advanced' (pT3-4N0)...
To evaluate the risk factors for mortality and morbidity related to radical cystectomy (RC) in a medium-sized academic centre, analyse rate trends of perioperative mortality, as although complications RC are lower modern than historic series, is still associated with marked risks.The study included 258 patients undergoing bladder cancer Turku University Hospital 1986-2005. Basic patient characteristics in-hospital, early (from hospital discharge 3 months) combined were analysed. Risk...
To evaluate in a multi-institutional study whether radiomic features useful for prostate cancer (PCa) detection from 3 Tesla (T) multi-parametric MRI (mpMRI) the transition zone (TZ) differ those peripheral (PZ).3T mpMRI, including T2-weighted (T2w), apparent diffusion coefficient (ADC) maps, and dynamic contrast-enhanced (DCE-MRI), were retrospectively obtained 80 patients at three institutions. This was approved by institutional review board of each participating institution. First-order...
Study Type – Prognosis (multi‐centre cohort) Level of Evidence 1b What’s known on the subject? and What does study add? More men than women develop bladder cancer (BC) but reasons why are unclear. Recent findings have implicated androgens, androgen receptors (AR) AR expression in BC. Previous studies showed that a significant loss was associated with aggressive However, these results been gathered limited series patients. We analyzed BC its correlation gender, grade, stage clinical outcome...
Study Type – Therapy (case series) Level of Evidence 4 What's known on the subject? and What does study add? The reported discordance between staging transurethral bladder resection radical cystectomy pathology in literature ranges from 20 to 80%.Correct cancer has direct implications for its management. upstaging organ‐confined (OC) non‐organ‐confined (nOC) disease been 40% cases. Lymphovascular invasion (LVI) is a factor be associated with poor clinical outcome. Pathological was observed...
Purpose To develop and validate a classifier system for prediction of prostate cancer (PCa) Gleason score (GS) using radiomics texture features T2-weighted imaging (T2w), diffusion weighted (DWI) acquired high b values, T2-mapping (T2). Methods T2w, DWI (12 0–2000 s/mm2), T2 data sets 62 patients with histologically confirmed PCa were at 3T surface array coils. The post-processed monoexponential kurtosis models, while T2w was standardized to common scale. Local statistics 8 different...
Computed tomography (CT) and bone scintigraphy (BS) are the imaging modalities currently used for distant metastasis staging of prostate cancer (PCa).To compare standard with newer potentially more accurate modalities.This prospective, single-centre trial (NCT03537391) enrolled 80 patients newly diagnosed high-risk PCa (International Society Urological Pathology grade group ≥3 and/or prostate-specific antigen [PSA] ≥20 cT ≥ T3; March 2018-June 2019) to undergo primary two three advanced...
SPOTLIGHT (NCT04186845) evaluated diagnostic performance and safety of radiohybrid
No AccessJournal of UrologyInvestigative Urology1 Jan 2012The FGFR3 Mutation is Related to Favorable pT1 Bladder Cancer Bas W.G. van Rhijn, Theo H. der Kwast, Liyang Liu, Neil E. Fleshner, Peter J. Bostrom, André N. Vis, Sultan S. Alkhateeb, Chris Bangma, Michael A.S. Jewett, Ellen C. Zwarthoff, Alexandre R. Zlotta, and Bharati Bapat RhijnBas Rhijn Division Urology, Princess Margaret Hospital, Toronto, Ontario, Canada Department Genetics, Samuel Lunenfeld Research Institute, Mount Sinai...
To evaluate the role of a 3T biparametric magnetic resonance imaging (bpMRI), T2 -weighted imaging, and three separate diffusion-weighted acquisitions combined with targeted biopsy (TB) for improving risk stratification men elevated prostate-specific antigen (PSA).Between March 2013 February 2015, 175 clinical suspicion prostate cancer (PCa) were offered bpMRI (NCT01864135) based on PCa (two repeated PSA measurements in range 2.5-20.0 ng/ml and/or abnormal digital rectal examination). Men an...
To evaluate monoexponential, stretched exponential, kurtosis, and biexponential models for diffusion-weighted imaging (DWI) of normal prostate cancer (PCa), using b-values up to 2000 s/mm(2) , in terms fitting quality repeatability.Eight healthy volunteers 16 PCa patients underwent a total four repeated 3T DWI examinations 12 b-values, respectively. The highest b-value was . normalized mean signal intensities regions interest, placed tissue anatomical images prostatectomy sections, were...
Abstract The human epidermal growth factor receptor 2 (HER2) is an oncogene targeted by several kinase inhibitors and therapeutic antibodies. While the endosomal trafficking of many other tyrosine kinases known to regulate their oncogenic signalling, prevailing view on HER2 that this predominantly retained cell surface. Here, we find sortilin-related 1 (SORLA; SORL1 ) co-precipitates with in cancer cells regulates subcellular distribution promoting recycling back plasma membrane. SORLA...
Magnetic resonance imaging (MRI) combined with targeted biopsy (TB) is increasingly used in men clinically suspected prostate cancer (PCa), but the long acquisition times, high costs, and inter-center/reader variability of routine multiparametric MRI limit its wider adoption.The aim was to validate a previously developed unique reporting protocol, IMPROD biparametric (bpMRI) (NCT01864135), clinical suspicion PCa multi-institutional trial (NCT02241122). bpMRI has average time 15 minutes (no...