A5009398971- Prostate Cancer Treatment and Research
- Prostate Cancer Diagnosis and Treatment
- Bladder and Urothelial Cancer Treatments
- Radiomics and Machine Learning in Medical Imaging
- Urologic and reproductive health conditions
- Urinary and Genital Oncology Studies
- Radiopharmaceutical Chemistry and Applications
- Molecular Biology Techniques and Applications
- Urinary Bladder and Prostate Research
- Hormonal and reproductive studies
- Renal cell carcinoma treatment
- Urological Disorders and Treatments
- Sexual function and dysfunction studies
- Cancer, Lipids, and Metabolism
- MRI in cancer diagnosis
- Cancer-related gene regulation
- Advanced Neural Network Applications
- Urinary Tract Infections Management
- Anesthesia and Sedative Agents
- Renal and related cancers
- Anesthesia and Pain Management
- AI in cancer detection
- Medical Imaging Techniques and Applications
- Cell Adhesion Molecules Research
- Infectious Disease Case Reports and Treatments
Turku University Hospital
2016-2025
University of Turku
2005-2025
University of Milan
2019
Finland University
2019
Satakunta Central Hospital
2014
University Consortium of Pori
2014
Radiomics or computer-extracted texture features derived from MRI have been shown to help quantitatively characterize prostate cancer (PCa). not explored depth in the context of predicting biochemical recurrence (BCR) PCa.To identify a set radiomic pretreatment biparametric (bpMRI) that may be predictive PCa BCR.Retrospective.In all, 120 patients two institutions, I1 and I2 , partitioned into training D1 (N = 70) independent validation D2 50) . All were followed for ≥3 years.3T, T2 -weighted...
Computed tomography (CT) and bone scintigraphy (BS) are the imaging modalities currently used for distant metastasis staging of prostate cancer (PCa).To compare standard with newer potentially more accurate modalities.This prospective, single-centre trial (NCT03537391) enrolled 80 patients newly diagnosed high-risk PCa (International Society Urological Pathology grade group ≥3 and/or prostate-specific antigen [PSA] ≥20 cT ≥ T3; March 2018-June 2019) to undergo primary two three advanced...
To evaluate the role of a 3T biparametric magnetic resonance imaging (bpMRI), T2 -weighted imaging, and three separate diffusion-weighted acquisitions combined with targeted biopsy (TB) for improving risk stratification men elevated prostate-specific antigen (PSA).Between March 2013 February 2015, 175 clinical suspicion prostate cancer (PCa) were offered bpMRI (NCT01864135) based on PCa (two repeated PSA measurements in range 2.5-20.0 ng/ml and/or abnormal digital rectal examination). Men an...
Magnetic resonance imaging (MRI) combined with targeted biopsy (TB) is increasingly used in men clinically suspected prostate cancer (PCa), but the long acquisition times, high costs, and inter-center/reader variability of routine multiparametric MRI limit its wider adoption.The aim was to validate a previously developed unique reporting protocol, IMPROD biparametric (bpMRI) (NCT01864135), clinical suspicion PCa multi-institutional trial (NCT02241122). bpMRI has average time 15 minutes (no...
Abstract Purpose Based on in vitro studies, it is known that androgen deprivation therapy (ADT) increases prostate-specific membrane antigen (PSMA) expression. Therefore, we hypothesised ADT improves the performance of PSMA-PET imaging primary staging prostate cancer. The purpose study was to demonstrate time course effect PSMA uptake different types metastatic lesions evaluated with 68 Ga-PSMA-11 PET/MRI. Methods Nine men treatment-naïve cancer were enrolled a prospective, registered...
To prospectively compare 18F-prostate-specific membrane antigen (PSMA)-1007 positron emission tomography (PET)/CT, whole-body magnetic resonance imaging (WBMRI) including diffusion-weighted (DWI) and standard computed (CT), in primary nodal staging of prostate cancer (PCa).Men with newly diagnosed unfavourable intermediate- or high-risk PCa underwent 18F-PSMA-1007 PET/CT, WBMRI DWI contrast-enhanced CT within a median 8 days. Six readers (two for each modality) independently reported pelvic...
Bilateral extended pelvic lymph node dissection at the time of radical prostatectomy is current standard care if indicated; often, however, performed in pN0 disease. With more accurate staging achieved with magnetic resonance imaging-targeted biopsies for prostate cancer diagnosis, indication bilateral may be revised. We aimed to assess feasibility unilateral era modern imaging.We analyzed a multi-institutional data set men cN0 disease diagnosed by biopsy who underwent and dissection. The...
Although prostate cancer (PCa) is the most common in men Western countries, there significant variability geographical incidence. This might result from genetic factors, discrepancies screening policies, or differences lifestyle. Gut microbiota has recently been associated with progression, but its role PCa unclear. Characterization of gut and functions PCa. In a prospective multicenter clinical trial (NCT02241122), profiles 181 suspicion were assessed utilizing 16S rRNA sequencing....
Rab7 has been shown to regulate the late steps of endocytic pathway. In bone-resorbing osteoclasts, it is involved in formation ruffled border, which a endosomal-like compartment plasma membrane. Here we report new Rab7-interacting protein, Rac1, another small GTPase protein that binds GTP-form as found with two-hybrid system. We demonstrate further colocalizes Rac1 at fusion zone border osteoclasts. other cell types, such fibroblast-like cells, partial colocalization perinuclear. Because...
Prostate cancer is one of the most common and heritable human cancers. Our aim was to find germline biomarkers that can predict disease outcome. We previously detected predisposing signals at 2q37, location prostate specific ANO7 gene. To investigate, in detail, associations between gene PrCa risk aggressiveness, sequenced castration resistant tumors together with samples from unselected patients unaffected males. Two pathogenic variants were discovered genotyped 1769 1711 Expression vs....
Although multiparametric magnetic resonance imaging (MRI) has high sensitivity, its lower specificity leads to a prevalence of false-positive lesions requiring biopsy.To develop and externally validate scoring system for MRI-detected Prostate Imaging Reporting Data System (PIRADS)/Likert ≥3 containing clinically significant prostate cancer (csPCa).The multicentre Rapid Access Diagnosis (RAPID) pathway included 1189 patients referred urology due elevated age-specific prostate-specific antigen...
Abstract Purpose To prospectively compare the ability of 18 F-PSMA-1007 PET/CT and whole-body MRI (WBMRI) with DWI to detect prostate cancer (PCa) lesions assess their local stage. Additionally, evaluate correlation between PSMA uptake on expression as assessed by immunohistochemistry. Methods Men newly diagnosed unfavourable intermediate or high-risk PCa underwent WBMRI before robot-assisted laparoscopic prostatectomy. Diagnostic accuracy for intraprostatic tumour localization, seminal...
Purpose To evaluate repeatability of prostate DWI‐derived radiomics and machine learning methods for cancer (PCa) characterization. Methods A total 112 patients with diagnosed PCa underwent 2 MRI examinations (Scan1 Scan2) performed on the same day. DWI was using 12 b‐values (0–2000 s/mm ), post‐processed kurtosis function, areas were annotated whole mount prostatectomy sections. 1694 radiomic features including Sobel, Kirch, Gradient, Zernike Moments, Gabor, Haralick, CoLIAGe, Haar wavelet...
The European Association of Urology guidelines recommend the use imaging, biomarkers, and risk calculators in men at prostate cancer. Risk predictive that combine multiparametric magnetic resonance imaging with prebiopsy variables aid as an individualized decision-making tool for patients cancer, advanced neural networking increases reliability these tools.
Background Multiparametric MRI of the prostate has been shown to improve risk stratification men with an elevated prostate‐specific antigen (PSA). However, long acquisition time, high cost, and inter‐center/reader variability a routine multiparametric limit its wider adoption. Purpose To develop validate nomograms based on unique rapid biparametric (bpMRI) qualitative quantitative derived variables for prediction clinically significant cancer (SPCa). Study Type Retrospective analyses single...
Abstract Existing tools for post-radical prostatectomy (RP) prostate cancer biochemical recurrence (BCR) prognosis rely on human pathologist-derived parameters such as tumor grade, with the resulting inter-reviewer variability. Genomic companion diagnostic tests Decipher tend to be tissue destructive, expensive, and not routinely available in most centers. We present a non-destructive method automated BCR prognosis, termed "Histotyping", that employs computational image analysis of...