A5079763596- Nerve injury and regeneration
- Nerve Injury and Rehabilitation
- Prostate Cancer Diagnosis and Treatment
- Prostate Cancer Treatment and Research
- Neural dynamics and brain function
- Urologic and reproductive health conditions
- Memory and Neural Mechanisms
- Neuroscience and Neuropharmacology Research
- Neural and Behavioral Psychology Studies
- Dysphagia Assessment and Management
- Traumatic Brain Injury and Neurovascular Disturbances
- Traumatic Brain Injury Research
- Spine and Intervertebral Disc Pathology
- Head and Neck Cancer Studies
- Peripheral Nerve Disorders
- Intracerebral and Subarachnoid Hemorrhage Research
- Voice and Speech Disorders
- Surgical Simulation and Training
- Cerebrospinal fluid and hydrocephalus
- Salivary Gland Tumors Diagnosis and Treatment
- Parkinson's Disease Mechanisms and Treatments
- Spatial Neglect and Hemispheric Dysfunction
- Transcranial Magnetic Stimulation Studies
- Head and Neck Surgical Oncology
- EEG and Brain-Computer Interfaces
Icahn School of Medicine at Mount Sinai
2013-2023
Center for Discovery
2020-2023
Hackensack Meridian Health
2020-2023
Mount Sinai Hospital
2017-2022
Henry Ford Health System
2017-2019
Johnson University
2019
NeuroSpine Institute
2019
Rutgers, The State University of New Jersey
2019
Hackensack University Medical Center
2010-2018
Montefiore Medical Center
2018
Dysphagia is very common in patients with Parkinson disease (PD) and often leads to aspiration pneumonia, the most cause of death PD. Current therapies are largely ineffective for dysphagia. Because pharyngeal sensation normally triggers swallowing reflex, we examined sensory nerves PD Lewy pathology.Sensory supplying pharynx were excised from autopsied pharynges obtained clinically diagnosed neuropathologically confirmed (n = 10) healthy age-matched controls 4). We glossopharyngeal nerve...
Parkinson disease (PD) is a neurodegenerative primarily characterized by cardinal motor manifestations and CNS pathology. Current drug therapies can often stabilize these symptoms, attention has shifted to the other nonmotor symptoms of PD that are resistant therapy. Dysphagia in perhaps most important drug-resistant symptom because it leads aspiration pneumonia, leading cause death. Here, we present direct evidence for degeneration pharyngeal nerves PD. We examined cervical vagal nerve...
Dysphagia (impaired swallowing) is common in patients with Parkinson disease (PD) and related to aspiration pneumonia, the primary cause of death PD. Therapies that ameliorate limb motor symptoms PD are ineffective for dysphagia. This suggests pathophysiology dysphagia may differ from affecting muscles, but little known about potential neuromuscular abnormalities swallowing muscles study examined fiber histochemistry pharyngeal constrictor cricopharyngeal sphincter postmortem specimens 8...
1. Inferotemporal, hippocampal, and parahippocampal units were recorded while monkeys alert (as judged by eye movements) but resting, in both light dark. 2. Spontaneous saccadic movements produced significant changes unit activity for 108 of 308 cells. This is shown to be extraretinal either because it occurred complete darkness or its timing relative the movement. 3. The total modulation ventral temporal lobe estimated over ten million action potentials.
ABSTRACT Little is known about the specializations of human tongue muscles. In this study, myofibrillar adenosine triphosphatase (mATPase) histochemical staining was used to study percentage and distribution slow twitch muscle fibers (slow MFs) within muscles four neurologically normal adults specimens from a 2‐year‐old human, newborn an adult with idiopathic Parkinson's disease (IPD), macaque monkey. The average MFs in 54%, IPD 45%, while neonatal (32%) monkey (28%) had markedly fewer MFs....
Treatment of human papillomavirus-related oropharyngeal squamous cell carcinoma (HPVOPC) results in unprecedented high survival rates but possibly unnecessary toxicity. We hypothesized that upfront surgery and neck dissection followed by reduced-dose adjuvant therapy for early intermediate HPVOPC would ultimately result equivalent progression-free (PFS) overall while reducing
The European Association of Urology guidelines recommend the use imaging, biomarkers, and risk calculators in men at prostate cancer. Risk predictive that combine multiparametric magnetic resonance imaging with prebiopsy variables aid as an individualized decision-making tool for patients cancer, advanced neural networking increases reliability these tools.
Sobotka, Stanislaw, Anna Nowicka, and James L. Ringo. Activity linked to externally cued saccades in single units recorded from hippocampal, parahippocampal, inferotemporal areas of macaques. J. Neurophysiol. 78: 2156–2163, 1997. We studied whether target-directed, commanded saccadic eye movements (saccades) induced activity cortex, the hippocampal formation, parahippocampal gyrus. The monkeys first were required fix their gaze on a small cross presented left or right center monitor screen....
Three macaques were trained on a task in which sequence of single visual images was presented serially, and the monkeys signaled whether image new or repeated one. The optic chiasm splenium corpus callosum transected, leaving anterior commissure as only path for cortical interhemispheric transfer. Images to one eye at time. Re-presentations same recognized correctly >95% trials. A robust stimulus-specific adaptation (i.e., reduced response image) seen population units recorded from...
We compared the performance of multiparametric magnetic resonance imaging for prediction extraprostatic extension in African American and Caucasian men evaluated racial disparities pathological outcomes after radical prostatectomy.We identified 975 patients who underwent prostatectomy with preoperative between January 2013 April 2019 at our institution. Multivariable logistic regression analysis was performed predicting extension, high grade prostate cancer (final pathology GGG [Gleason...
Biochemical recurrence (BCR) affects a significant proportion of patients who undergo robotic-assisted laparoscopic prostatectomy (RALP).To evaluate the performance routine clinical prostate multiparametric magnetic resonance imaging (mpMRI) and Decipher genomic classifier score for prediction biochemical in underwent RALP.Retrospective cohort study.Ninety-one RALP performed by single surgeon, had mpMRI before RALP, taken from samples, specific antigen (PSA) follow-up >3 years or BCR within...
Abstract Background Aggressive histologic worst pattern of invasion (WPOI) in surrounding soft tissue has been shown to be predictive higher local recurrence and poorer survival oral cavity squamous cell carcinoma (OCSCC) patients. This study investigates whether aggressive WPOI can predict the mandibular phenotype. Methods Patients consecutively diagnosed with OCSCC undergoing a mandibulectomy (marginal or segmental) between 2013 2018 were reviewed. Senior physicians re‐reviewed radiologic...
Abstract Background The detection of prostate cancer requires histological confirmation in biopsy core. Currently, number unnecessary biopsies are being performed the United States. This is due to absence appropriate decision‐making protocol. Aim To develop and validate a 4K score/multiparametric magnetic resonance imaging (mpMRI)‐based nomogram predict (PCa), clinically significant (csPCa), unfavorable (uPCa). Methods Results Retrospective, single‐center study evaluating cohort 574 men with...
Background: Cancer patients with COVID-19 have a poor disease course. Among tumor types, prostate cancer and share several risk factors, the interaction of is purported to an adverse outcome. Methods: This was single-institution retrospective study on 286,609 who underwent test at Mount Sinai Hospital system from March 2020 December 2020. Chi-square/Fisher’s exact tests were used summarize baseline characteristics categorical data, Mann–Whitney U for continuous variables. Univariable...
Multiparametric magnetic resonance imaging (MRI) is increasingly used to diagnose prostate cancer (PCa). It not yet established whether all men with negative MRI (Prostate Imaging-Reporting and Data System version 2 score <3) should undergo biopsy or not.To develop validate a prediction model that uses clinical parameters reduce unnecessary biopsies by predicting PCa clinically significant (csPCa) for findings who are at risk of harboring PCa.This was retrospective analysis 200 underwent...