A5007674670- Bladder and Urothelial Cancer Treatments
- Monoclonal and Polyclonal Antibodies Research
- Renal cell carcinoma treatment
- Epigenetics and DNA Methylation
- Cellular transport and secretion
- HER2/EGFR in Cancer Research
- Cancer, Lipids, and Metabolism
- Genomics and Chromatin Dynamics
- RNA Research and Splicing
- Prostate Cancer Diagnosis and Treatment
- Amino Acid Enzymes and Metabolism
- Nuclear Structure and Function
- Urinary and Genital Oncology Studies
- Prostate Cancer Treatment and Research
Turku University Hospital
2015-2025
University of Turku
2015-2025
Abstract The human epidermal growth factor receptor 2 (HER2) is an oncogene targeted by several kinase inhibitors and therapeutic antibodies. While the endosomal trafficking of many other tyrosine kinases known to regulate their oncogenic signalling, prevailing view on HER2 that this predominantly retained cell surface. Here, we find sortilin-related 1 (SORLA; SORL1 ) co-precipitates with in cancer cells regulates subcellular distribution promoting recycling back plasma membrane. SORLA...
Abstract Purpose To prospectively compare the ability of 18 F-PSMA-1007 PET/CT and whole-body MRI (WBMRI) with DWI to detect prostate cancer (PCa) lesions assess their local stage. Additionally, evaluate correlation between PSMA uptake on expression as assessed by immunohistochemistry. Methods Men newly diagnosed unfavourable intermediate or high-risk PCa underwent WBMRI before robot-assisted laparoscopic prostatectomy. Diagnostic accuracy for intraprostatic tumour localization, seminal...
Many patients with muscle-invasive bladder cancer (BC) are either ineligible for or do not benefit from cisplatin-based chemotherapy, and there is an unmet need to estimate individuals' drug sensitivities. We investigated the suitability of conditionally reprogrammed (CR) cells characterization BC properties their feasibility personalized sensitivity screening. The CR cultures were established six tumors varying histology stage. Four successfully propagated genomic, transcriptomic, protein...
Background Prostate cancer (PCa) is the most common among men in western countries. While active surveillance increasingly utilized, majority of patients are currently treated with radical prostatectomy. In order to avoid over-treatment, there an indisputable need for reliable biomarkers identify potentially aggressive and lethal cases. Nuclear intermediate filament proteins called lamins play a role chromatin organization, gene expression cell stiffness. The lamin A associated poor outcome...
To evaluate the expression of alanine-serine-cysteine-transporter 2 (ASCT2) and L-type amino acid transporter1 (LAT1) in prostate cancer (PCa) their impact on uptake 18F-1-amino-3-fluorocyclobutane-1-carboxylic (18F-fluciclovine) which is approved for detection recurrent PCa. Twenty-five hormone-naïve patients with histologically confirmed PCa underwent PET/CT before prostatectomy. Dynamic imaging was performed immediately after injection 368 ± 10 MBq 18F-fluciclovine expressed as SUVmax at...