A5010372722- Cellular transport and secretion
- Cell Adhesion Molecules Research
- Monoclonal and Polyclonal Antibodies Research
- Glycosylation and Glycoproteins Research
- Lipid Membrane Structure and Behavior
- Cellular Mechanics and Interactions
- HER2/EGFR in Cancer Research
- Sphingolipid Metabolism and Signaling
- Surfactants and Colloidal Systems
- Erythrocyte Function and Pathophysiology
Åbo Akademi University
2016-2024
University of Turku
2018-2024
Turku Centre for Computer Science
2019-2024
Turku Centre for Biotechnology
2018
Abstract The human epidermal growth factor receptor 2 (HER2) is an oncogene targeted by several kinase inhibitors and therapeutic antibodies. While the endosomal trafficking of many other tyrosine kinases known to regulate their oncogenic signalling, prevailing view on HER2 that this predominantly retained cell surface. Here, we find sortilin-related 1 (SORLA; SORL1 ) co-precipitates with in cancer cells regulates subcellular distribution promoting recycling back plasma membrane. SORLA...
Spatially controlled, cargo-specific endocytosis is essential for development, tissue homeostasis, and cancer invasion often hijacked by viral infections 1 . Unlike clathrin-mediated endocytosis, which exploits adaptors selective protein internalization, the clathrin dynamin-independent endocytic pathway (CLIC-GEEC, CG-pathway) has until now been considered a bulk internalization route fluid phase, glycosylated membrane proteins lipids 2,3 Although core molecular players of CG have recently...
EPLIN, an actin-binding protein, has been described as both a tumour promoter and suppressor in different cancers. EPLIN isoform(α or β)-specific functions, which remain largely unknown, could explain these opposing roles. We observed distinct EPLIN-isoform localization; EPLINα is recruited to actin plasma membrane ruffles endosomes, while EPLINβ resides on stress fibers. identified two regions demonstrated interaction with Rab21, established regulator of β1-integrin endosomal traffic....
Abstract Human epidermal growth factor receptor 2 (HER2) is an oncogene targeted by several kinase inhibitors and therapeutic antibodies. Endosomal trafficking of many other tyrosine kinases regulates their oncogenic signaling, but the prevailing view that HER2 retained on cell surface. Here we reveal in cancer cells Sortilin related 1 (SORLA; SORL1 ) forms a complex with its subcellular distribution promoting recycling endosomal back to plasma membrane. Expression SORLA lines bladder...