A5018908850- Bladder and Urothelial Cancer Treatments
- Prostate Cancer Diagnosis and Treatment
- Prostate Cancer Treatment and Research
- Urinary and Genital Oncology Studies
- Cancer, Lipids, and Metabolism
- Urological Disorders and Treatments
- Renal cell carcinoma treatment
- Colorectal Cancer Screening and Detection
- Esophageal Cancer Research and Treatment
- Hormonal and reproductive studies
- Health Systems, Economic Evaluations, Quality of Life
- Epigenetics and DNA Methylation
- Urologic and reproductive health conditions
- Cancer Immunotherapy and Biomarkers
- Cancer Research and Treatments
- Cancer Genomics and Diagnostics
- Genital Health and Disease
- Global Cancer Incidence and Screening
- Renal and related cancers
- Economic and Financial Impacts of Cancer
- Metabolism, Diabetes, and Cancer
- Galaxies: Formation, Evolution, Phenomena
- Urinary Bladder and Prostate Research
- Mathematical Biology Tumor Growth
- Cancer survivorship and care
University of Toronto
2016-2025
University Health Network
2016-2025
Princess Margaret Cancer Centre
2016-2025
Public Health Ontario
2021-2025
University of Ottawa
2023-2025
Health Net
2017-2025
Artificial Intelligence in Medicine (Canada)
2024
Institute for Clinical Evaluative Sciences
2014-2023
Mount Sinai Hospital
2005-2023
University Hospitals Birmingham NHS Foundation Trust
2023
Purpose Multidisciplinary management improves complex treatment decision making in cancer care, but its impact for bladder (BC) has not been documented. Although radical cystectomy (RC) currently is viewed as the standard of care muscle-invasive (MIBC), radiotherapy-based, bladder-sparing trimodal therapy (TMT) that combines transurethral resection tumor, chemotherapy radiation sensitization, and external beam radiotherapy emerged a valid option. In absence randomized studies, this study...
Purpose To evaluate the association between cumulative duration of metformin use after prostate cancer (PC) diagnosis and all-cause PC-specific mortality among patients with diabetes. Patients Methods We used a population-based retrospective cohort design. Data were obtained from several Ontario health care administrative databases. Within men older than age 66 years incident diabetes who subsequently developed PC, we examined effect antidiabetic medication exposure PC on mortality. Crude...
The purpose of this guideline is to provide a useful reference on the effective evidence-based diagnoses and management non-metastatic upper tract urothelial carcinoma (UTUC).The Pacific Northwest Evidence-based Practice Center Oregon Health & Science University (OHSU) team conducted searches in Ovid MEDLINE (1946 March 3rd, 2022), Cochrane Central Register Controlled Trials (through January Database Systematic Reviews 2022). were updated August 2022. When sufficient evidence existed, body...
Background Pembrolizumab has a manageable safety profile as described in its label, which was primarily based on 2799 patients who participated clinical trials for melanoma or non-small cell lung cancer. Here, we evaluated the of pembrolizumab broader population from 31 advanced cancer across 19 types. Methods Safety analyzed received at least one dose (200 mg every 3 weeks [Q3W], 10 mg/kg Q2W Q3W, 2 Q3W). Adverse events (AEs) and immune-mediated AEs infusion reactions were evaluated....
350 Background: The PD-1 inhibitor pembro has durable antitumor activity in pts with metastatic urothelial carcinoma. Upregulation of the pathway been observed BCG-resistant NMIBC, suggesting may benefit. Efficacy and safety HR, BCG-unresponsive NMIBC was evaluated single-arm phase 2 KEYNOTE-057 study; updated results for carcinoma situ (CIS) or without papillary tumor (cohort A) are reported. Methods: Pts histologically confirmed CIS disease, who received adequate BCG therapy were...
An elevated neutrophil-to-lymphocyte ratio (NLR) is associated with poor outcome in various tumours. Its prognostic utility patients urothelial carcinoma of the bladder (UCB) undergoing radical cystectomy (RC) yet to be fully elucidated. A cohort RC for UCB a tertiary referral centre between 1992 and 2012 was analysed. Neutrophil-to-lymphocyte computed using complete blood counts performed pre-RC, or before neo-adjuvant chemotherapy where applicable. Time-dependent receiver operating...
We determined if the USPSTF recommendation against prostate specific antigen screening was associated with a change in biopsy and cancer detection rates.We conducted time series analysis (October 2008 to June 2013) of biopsies performed at University Health Network (Toronto). Biopsies for active surveillance or solely targeting magnetic resonance imaging detected lesions were excluded from study. Interventional ARIMA models step functions used examine changes number cancers per month. Low...
We aimed to determine the risk of short- and long-term stroke, as well accidental injury, in patients discharged from an emergency department who were given a diagnosis peripheral vestibular disorder.In this population-based, retrospective, cohort study, we identified all adult Ontario, Canada, between 2006 2011, with primary disorder. assessed hospitalized strokes at 7, 30, 90, 365 days, subsequent falls, motor vehicle accidents, fractures, burns. To provide context, same outcomes...
Background In validation studies, risk models for clinically significant prostate cancer (csPCa; Gleason score ≥3+4) combining multiparametric MRI and clinical factors have demonstrated poor calibration (over- underprediction) limited use in avoiding unnecessary biopsies. Purpose MRI-based following local recalibration were compared with a strategy that combined Prostate Imaging Data Reporting System (PI-RADS; version 2) prostate-specific antigen density (PSAd) to assess the potential...
A phase 1b study of photosensitizer TLD-1433-mediated photodynamic therapy (PDT) was performed in bacillus Calmette-Guérin (BCG)-unresponsive non-muscle-invasive bladder cancer (NMIBC) patients.The primary objectives were safety and tolerability PDT, with secondary (1) pharmacokinetic (PK) properties TLD-1433 (2) efficacy, as evaluated by recurrence-free survival complete response (CR) at 90 180 d for patients treated the maximum recommended starting dose (0.35 mg/cm2 surface area)...
Neoadjuvant chemotherapy (NAC) improves survival for patients with muscle-invasive bladder cancer (MIBC) treated radical cystectomy. Studies on the potential benefit of NAC before radiation-based therapy (RT) are conflicting.
The PCPT has demonstrated a higher incidence of high grade (Gleason pattern 4 or greater) prostate cancers among men randomized to finasteride. One plausible explanation for this finding is that tumor as assigned by TRUS guided biopsy artifactually associated with volume.We evaluated our institutional data set biopsies in the last 3 years and identified 369 cases cancer fit criteria PSA less than 10 ng/ml, at center RP center. We risk factors Gleason greater on then specimens from same...