A5012006013- Prostate Cancer Diagnosis and Treatment
- Prostate Cancer Treatment and Research
- Bladder and Urothelial Cancer Treatments
- Renal cell carcinoma treatment
- Urologic and reproductive health conditions
- Urinary and Genital Oncology Studies
- Cancer Genomics and Diagnostics
- Urological Disorders and Treatments
- Renal and related cancers
- Cancer Cells and Metastasis
- Advanced Radiotherapy Techniques
- Colorectal Cancer Surgical Treatments
- Radiomics and Machine Learning in Medical Imaging
- Cancer Immunotherapy and Biomarkers
- Pediatric Urology and Nephrology Studies
- Immune cells in cancer
- Pelvic and Acetabular Injuries
- Cardiac, Anesthesia and Surgical Outcomes
- Ureteral procedures and complications
- Molecular Biology Techniques and Applications
- Urinary Tract Infections Management
- Single-cell and spatial transcriptomics
- Surgical Simulation and Training
- Healthcare Policy and Management
- Genetic and Kidney Cyst Diseases
Harvard University Press
1998-2025
Massachusetts General Hospital
2015-2024
Harvard University
2015-2024
Johns Hopkins Medicine
2023
Johns Hopkins University
2023
Exelixis (United States)
2023
Bristol-Myers Squibb (Germany)
2023
Boston University
2023
Brigham and Women's Hospital
2016
Robotics Research (United States)
2011
Circulating signals of drug resistance Cancer drugs often lose their effectiveness because tumors acquire genetic changes that confer resistance. Ideally, patients would be switched to a different before tumor growth resumes, but this requires early knowledge how arose. Miyamoto et al. have developed non-invasive method spot by sequencing RNA transcripts in single circulating cells (CTCs) (see the Perspective Nanus and Giannakakou). For example, prostate cancer patients, was triggered...
Rare circulating tumor cells (CTCs) are present in the blood of patients with metastatic epithelial cancers but have been difficult to measure routinely. We report a quantitative automated imaging system for analysis prostate CTCs, taking advantage prostate-specific antigen (PSA), unique tumor-associated marker. The specificity PSA staining enabled optimization criteria baseline image intensity, morphometric measurements, and integration multiple signals three-dimensional microfluidic...
The NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) for Prostate Cancer Early Detection provide recommendations prostate cancer screening healthy men who have elected to participate an early detection program. focus on minimizing unnecessary procedures and limiting the of indolent disease. These Insights summarize Panel's most significant discussions 2016 guideline update, which included issues surrounding high-risk populations (ie, African Americans, BRCA1/2 mutation...
The treatment of low-risk primary prostate cancer entails active surveillance only, while high-risk disease requires multimodal including surgery, radiation therapy, and hormonal therapy. Recurrence development metastatic remains a clinical problem, without clear understanding what drives immune escape tumor progression. Here, we comprehensively describe the microenvironment localized in comparison with adjacent normal samples healthy controls. Single-cell RNA sequencing high-resolution...
The NCCN Guidelines for Prostate Cancer Early Detection provide recommendations individuals with a prostate who opt to participate in an early detection program after receiving the appropriate counseling on pros and cons. These Insights summary of recent updates regard testing protocol, use multiparametric MRI, management negative biopsy results optimize clinically significant cancer minimize indolent disease.
Abstract Background Despite therapeutic advances, once a cancer has metastasized to the bone, it represents highly morbid and lethal disease. One third of patients with advanced clear cell renal carcinoma (ccRCC) present bone metastasis at time diagnosis. However, metastatic niche in humans, including immune stromal microenvironments, not been well-defined, hindering progress towards identification targets. Methods We collected fresh patient samples performed single-cell transcriptomic...
Abstract Blood-based biomarkers are critical in metastatic prostate cancer, where characteristic bone metastases not readily sampled, and they may enable risk stratification localized disease. We established a sensitive high-throughput strategy for analyzing circulating tumor cells (CTC) using microfluidic cell enrichment followed by digital quantitation of prostate-derived transcripts. In prospective study 27 patients with castration-resistant cancer treated first-line abiraterone,...
The NCCN Guidelines for Prostate Cancer Early Detection provide recommendations men choosing to participate in an early detection program prostate cancer. These Insights highlight notable recent updates. Overall, the 2014 update represents a more streamlined and concise set of recommendations. panel stratified age ranges at which initiating testing cancer should be considered. Indications biopsy include both cutpoint use multiple risk variables combination. In addition other biomarkers...
Purpose Prostate-specific antigen (PSA) level in midlife predicted future prostate cancer (PCa) mortality an unscreened Swedish population. Our purpose was to determine if a baseline PSA during predicts lethal PCa US population with opportunistic screening. Materials and Methods We conducted nested case-control study among men age 40 59 years who gave blood before random assignment the Physicians’ Health Study, randomized, placebo-controlled trial of aspirin β-carotene 22,071 male physicians...
Abstract Clear cell renal carcinoma (ccRCC) is the most common type of kidney cancer in adults. When ccRCC localized to kidney, surgical resection or ablation tumor often curative. However, metastatic setting, remains a highly lethal disease. Here we use fresh patient samples that include treatment-naive primary tissue, matched adjacent normal as well collected from patients with bone metastases. Single-cell transcriptomic analysis cells tumors reveals distinct transcriptional signature...
Prostate cancer represents a spectrum of disease that ranges from nonaggressive, slow-growing may not require treatment to aggressive, fast-growing does. The NCCN Guidelines for Cancer Early Detection provide set sequential recommendations detailing screening and evaluation strategy maximizing the detection prostate is potentially curable that, if left undetected, risk patient. guidelines were developed healthy men who have elected participate in early cancer, they focus on minimizing...
Abstract BACKGROUND Selecting treatment for clinically localized prostate cancer remains an ongoing challenge. Previous decision analyses focused on a hypothetical patient with average preferences, but preferences differ similar patients, implying that their optimal therapies may also differ. METHODS A model was constructed comparing 4 treatments cancer: 1) radical prostatectomy (RP); 2) external beam radiation (EB); 3) brachytherapy (BT); and 4) watchful waiting (WW). Published data were...
PURPOSE To investigate the use of radiation with radiosensitizing chemotherapy following repeated transurethral resection (trimodality therapy) as an alternative to radical cystectomy in T1 bladder cancer which has failed Bacillus Calmette-Guerin (BCG). PATIENTS AND METHODS Patients recurrent bladders who had BCG and were recommended undergo treated trimodality therapy. The primary end point was 3-year freedom from cystectomy. Secondary points distant metastasis at 3 5 years, local...