A5044820153- Prostate Cancer Treatment and Research
- Prostate Cancer Diagnosis and Treatment
- Bladder and Urothelial Cancer Treatments
- Global Cancer Incidence and Screening
- Urinary and Genital Oncology Studies
- Renal cell carcinoma treatment
- Patient-Provider Communication in Healthcare
- Urological Disorders and Treatments
- Genital Health and Disease
- Healthcare Policy and Management
- Economic and Financial Impacts of Cancer
- Health Systems, Economic Evaluations, Quality of Life
- Renal and related cancers
- Health Literacy and Information Accessibility
- Congenital heart defects research
- Urologic and reproductive health conditions
- Diversity and Career in Medicine
- Palliative Care and End-of-Life Issues
- Mobile Health and mHealth Applications
- Cancer, Lipids, and Metabolism
- Radiopharmaceutical Chemistry and Applications
- Colorectal Cancer Screening and Detection
- Breastfeeding Practices and Influences
- Primary Care and Health Outcomes
- Pelvic floor disorders treatments
Vanderbilt University Medical Center
2016-2025
Memorial Sloan Kettering Cancer Center
2011-2023
Vanderbilt-Ingram Cancer Center
2015-2023
Vanderbilt University
2010-2023
Bristol-Myers Squibb (Germany)
2016-2023
Breast Cancer Research Foundation
2023
Exelixis (United States)
2023
Hurley Medical Center
2021
Michigan State University
2021
Seoul Medical Center
2020
The NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) for Prostate Cancer Early Detection provide recommendations prostate cancer screening healthy men who have elected to participate an early detection program. focus on minimizing unnecessary procedures and limiting the of indolent disease. These Insights summarize Panel's most significant discussions 2016 guideline update, which included issues surrounding high-risk populations (ie, African Americans, BRCA1/2 mutation...
The summary presented herein covers recommendations on the early detection of prostate cancer and provides a framework to facilitate clinical decision-making in implementation screening, biopsy, follow-up. This is Part I two-part series that focuses screening. Please refer II for discussion initial repeat biopsies as well biopsy technique. systematic review utilized inform this guideline was conducted by an independent methodological consultant. based searches Ovid MEDLINE Embase Cochrane...
The NCCN Guidelines for Prostate Cancer Early Detection provide recommendations individuals with a prostate who opt to participate in an early detection program after receiving the appropriate counseling on pros and cons. These Insights summary of recent updates regard testing protocol, use multiparametric MRI, management negative biopsy results optimize clinically significant cancer minimize indolent disease.
The summary presented herein covers recommendations on the early detection of prostate cancer and provides a framework to facilitate clinical decision-making in implementation screening, biopsy, follow-up. This is Part II two-part series focusing initial repeat biopsies, biopsy technique. Please refer I for discussion screening recommendations. systematic review utilized inform this guideline was conducted by an independent methodological consultant. based searches Ovid MEDLINE Embase...
Abstract Summary: Nkx2‐5 , one of the earliest cardiac‐specific markers in vertebrate embryos, was used as a genetic locus to knock Cre recombinase gene by homologous recombination. Offspring resulting from heterozygous Nkx2‐5/Cre mice mated ROSA26 ( R26R ) reporter provided model system for following activity β‐galactosidase (β‐gal) activity. β‐gal initially observed early cardiac crescent, cardiomyocytes looping heart tube, and epithelium first pharyngeal arch. In later stage embryos...
Mutations in developmental regulatory genes have been found to be responsible for some cases of congenital heart defects. One such gene is Gata4, a zinc finger transcription factor. In order circumvent the early embryonic lethality Gata4-null embryos and investigate role myocardial Gata4 expression cardiac development, we used Cre/loxP technology conditionally delete myocardium mice at an late time point morphogenesis. Early deletion by Nkx2-5Cre resulted hearts with striking thinning,...
The Bmp4 signaling molecule is expressed in ventral splanchnic and branchial-arch mesoderm outflow-tract (OFT) myocardium, suggesting a role for OFT development. Inactivation of the caudal branchial arch myocardium by using conditional null allele Nkx2.5cre recombinase resulted abnormal morphogenesis arteries (BAAs) defective septation. Expression aortic-sac myocardial markers was reduced expression sm22LacZ transgene, smooth-muscle marker, attenuated BAAs conotruncus Nkx2.5cre; mutants....
<h3>Importance</h3> Low health literacy is known to adversely affect outcomes in patients with chronic medical conditions. To our knowledge, the association of postoperative has not been studied in-depth a surgical patient population. <h3>Objective</h3> evaluate undergoing major abdominal surgery. <h3>Design, Setting, and Participants</h3> From November 2010 December 2013, 1239 who were elective gastric, colorectal, hepatic, pancreatic resections for both benign malignant disease at single...
The association between health literacy and all-cause mortality among cancer patients remains unclear. This is a retrospective cohort study of 9603 diagnosed with prostate, lung, breast, renal, colorectal, brain, head neck, bladder, pancreatic, liver, sarcoma, gastric cancers who were screened for 2008 2018, using the Brief Health Literacy Screen (BHLS). Higher scores (range, 3-15) indicate higher literacy. was estimated multivariable Cox proportional hazards models. A total 8608 (89%)...
Codification of COVID-19-era use telemedicine as a permanent feature US healthcare has been discussed it may increase accessibility and equity. This study assesses whether is associated with improved differential access to cancer care for racial ethnic minorities. We conducted cross-sectional analysis the National Health Interview Survey from July 2020 December 2021 estimated prevalence utilization in both population (N=46,799) subgroup patients (N=7,784). Complex survey-weighted...
The genetic control of cell fate specification, morphogenesis and expansion the spleen, a crucial lymphoid organ, is poorly understood. Recent studies mutant mice implicate various transcription factors in spleen development, but hierarchical relationships between these have not been explored. In this report, we establish network that regulates ontogeny, by analyzing asplenic for Pbx1, Hox11 (Tlx1), Nkx3.2 (Bapx1) Pod1 (capsulin, Tcf21). We show Nkx2.5, among earliest known markers splenic...
COUP-TFII, an orphan member of the steroid receptor superfamily,has been implicated in mesenchymal-epithelial interaction during organogenesis. The generation a lacZ knock-in allele COUP-TFII locus mice allows us to use X-gal staining follow expression developing stomach. We found is expressed mesenchyme and epithelium Conditional ablation floxed by Nkx3-2Cre recombinase gastric results dysmorphogenesis stomach manifested major patterning defects posteriorization radial patterning....
PURPOSE Men diagnosed with prostate cancer have multiple options available for treatment. Previous reports indicated a trend of differing modalities treatment chosen by African American and white men. We investigated the role ethnicity in primary choice how this affected overall cancer-specific mortality. METHODS By utilizing data abstracted from Cancer Prostate Strategic Urologic Research Endeavor (CaPSURE), patients were compared ethnicity, treatment, number comorbidities, risk level...
Approximately 70% of all suicides in patients aged >60 years are attributed to physical illness, with higher rates noted cancer. The purpose the current study was characterize suicide among genitourinary cancers and identify factors associated this specific cohort.Patients prostate, bladder, kidney, testis, penile cancer were identified Surveillance, Epidemiology, End Results database (1988-2010). Standardized mortality ratios (SMRs) 95% confidence intervals (95% CIs) calculated for each...
Health literacy is the ability to obtain, comprehend, and act on medical information an independent predictor of health outcomes in patients with chronic conditions. However, little has been reported regarding potential association surgical outcomes. We hypothesized that patient complications after radical cystectomy would be associated literacy. In a sample 368 patients, we found higher scores (as determined by Brief Literacy Screen) were decreased odds developing minor (odds ratio = 0.90,...
Background Previous studies have demonstrated an association between a diagnosis of cancer and the risk suicide; however, they failed to account for psychiatric care before diagnosis, which may confound this relationship. The objective study was assess effect on suicide, accounting prediagnosis utilization. Methods All adult residents Ontario, Canada who were diagnosed with (1 prostate, breast, colorectal, melanoma, lung, bladder, endometrial, thyroid, kidney, or oral cancer) 1997 2014...
Among patients with cancer, prior research suggests that mental illness may have reduced survival. The objective was to assess the impact of psychiatric utilisation (PU) cancer diagnosis on survival outcomes.All residents Ontario diagnosed one top 10 malignancies (1997-2014) were included. primary exposure gradient (PUG) score in 5 years cancer: 0: none, 1: outpatient, 2: emergency department, 3: hospital admission. A multivariable, cause-specific hazard model used effect PUG cancer-specific...