A5055948301- Coronary Interventions and Diagnostics
- Cardiac Imaging and Diagnostics
- Acute Myocardial Infarction Research
- Cerebrovascular and Carotid Artery Diseases
- Advanced Radiotherapy Techniques
- Prostate Cancer Treatment and Research
- Prostate Cancer Diagnosis and Treatment
- Radiopharmaceutical Chemistry and Applications
- Medical Imaging Techniques and Applications
- Working Capital and Financial Performance
- Angiogenesis and VEGF in Cancer
- Radiation Dose and Imaging
- Integrated Circuits and Semiconductor Failure Analysis
- Advanced X-ray and CT Imaging
- Peripheral Artery Disease Management
- Radiomics and Machine Learning in Medical Imaging
- Antiplatelet Therapy and Cardiovascular Diseases
- Chemotherapy-induced cardiotoxicity and mitigation
- Cardiac Valve Diseases and Treatments
- Venous Thromboembolism Diagnosis and Management
- Ultrasound and Hyperthermia Applications
- Pain Management and Treatment
- International Business and FDI
- Cardiovascular Disease and Adiposity
- Global trade and economics
Cancer Care Ontario
2025
Women's College Hospital
2018-2024
University Health Network
2018-2024
University of Toronto
1998-2024
Mount Sinai Hospital
2018-2024
Toronto General Hospital
2021-2024
Princess Margaret Cancer Centre
2018-2021
MedStar Washington Hospital Center
2006-2020
University of Kansas
2020
World Bank
2017
Background —Treatment of in-stent restenosis presents a critical limitation intracoronary stent implantation. Ionizing radiation has been shown to decrease neointimal formation within stents in animal models and initial clinical trials. We studied the effects γ-radiation therapy versus placebo on angiographic outcomes patients with restenosis. Methods Results —One hundred thirty underwent successful coronary intervention were then blindly randomized receive either 192 Ir (15 Gy) or placebo....
Background —Intracoronary γ-radiation therapy reduces recurrent in-stent restenosis (ISR). This study, BETA WRIST (Washington Radiation for In-Stent Trial) was designed to examine the efficacy and safety of β-emitter 90-yttrium prevention ISR. Methods Results —A total 50 consecutive patients with ISR in native coronaries underwent percutaneous transluminal coronary angioplasty, laser rotational atherectomy, and/or stent implantation. Afterward, a segmented balloon catheter positioned...
The Washington Radiation for In-Stent Restenosis Trial is a double-blinded randomized study evaluating the effects of intracoronary radiation therapy (IRT) in patients with in-stent restenosis (ISR).One hundred thirty ISR (100 native coronary and 30 vein grafts) underwent percutaneous transluminal angioplasty, laser ablation, rotational atherectomy, or additional stenting (36% lesions). Patients were to either 192-Iridium IRT placebo, prescribed dose 15 Gy 2-mm radial distance from center...
<h3>Importance</h3> Although myocardial injury can occur with acute COVID-19, there is limited understanding of changes metabolism in recovered patients. <h3>Objective</h3> To examine metabolic early after recovery from COVID-19 using fluorodeoxyglucose–positron emission tomography (PET) and associate these to abnormalities cardiac magnetic resonance imaging (MRI)–based function tissue characterization measures inflammatory blood markers. <h3>Design, Setting, Participants</h3> This...
Background MRI-guided focal therapy (FT) allows for accurate targeting of localized clinically significant prostate cancer (csPCa) while preserving healthy tissue, but the long-term outcomes this approach require more study. Purpose To assess 2-year oncological and functional men with intermediate-risk (PCa) treated targeted FT. Materials Methods In single-center prospective phase II trial, unifocal PCa underwent transrectal focused ultrasound between July 2016 2019. Planned ablation volumes...
Intracoronary radiation therapy is effective in reducing the recurrence of in-stent stenosis native coronary arteries. We examined effects intravascular gamma patients with restenosis saphenous-vein bypass grafts.
Background To reduce adverse effects of whole-gland therapy, participants with localized clinically significant prostate cancer can undergo MRI-guided focal therapy. Purpose explore safety and early oncologic functional outcomes targeted high-intensity focused ultrasound performed under for intermediate-risk cancer. Materials Methods In this prospective phase II trial, between February 2016 July 2019, men unifocal visible at MRI were treated transrectal ultrasound. The primary end point was...
To evaluate the diagnostic and prognostic significance of combined cardiac
Diagnosis of cancer therapy-related cardiac dysfunction (CTRCD) remains a challenge. Cardiovascular magnetic resonance (CMR) provides accurate measurement left ventricular ejection fraction (LVEF), but access to repeated scans is limited.
The effects of the vasoconstrictor phenylephrine and vasodilator hydralazine on blood flow to tumor were studied compared those normal tissues in vivo. Regional cardiac output measured with use radioactive microspheres 150- 250-g inbred Harlan F344 rats bearing subcutaneous nodules two types transplantable carcinoma (“hard” “soft”) microscopically different vascular patterns. Three groups treated hydralazine, saline, or phenylephrine, regional was determined at time maximum pressure...
In patients with squamous cell carcinoma of the anal canal (ACC), disease stage influences treatment plans and determines prognosis. Our purpose was to determine impact PET on initial staging presumed stages II-IV ACC assess association per conventional workup (CW) imaging patient outcomes. Methods: this multicenter registry, CW or equivocal findings for a specific were included. Demographic data according American Joint Committee Cancer (AJCC) version 7 as determined by recorded compared...
Background —The main complications of PTCA remain thrombosis and restenosis. Recent studies have demonstrated reduction in the neointimal hyperplasia after intracoronary radiation (IR) with doses 10 to 25 Gy ionizing delivered by either β- or γ-emitters injured vessels. The purpose this study was examine effect on rate (TR) porcine coronary arteries. Methods Results —Thirty-four juvenile swine (63 arteries) were subjected overstretch balloon injury followed IR 0 18 γ-radiation. Two weeks...
Late total occlusion after vascular brachytherapy (VBT) continues to be a serious complication. Delayed reendothelialization was suggested as pivotal cause, but the time course for complete healing is unknown.Seventy-two rabbit iliac arteries underwent stent implantation and were treated with gamma-radiation using 192Ir. The prescribed doses 0 Gy (controls, n=24 arteries), 15 (n=24), or 30 (n=24) at 2 mm. Animals killed 1 month 3 months 6 analyzed histomorphometry scanning electron...
Dissecting the genetic basis of natural variation in disease response hosts provides insights into coevolutionary dynamics host-pathogen interactions. Here, a genome-wide association study Drosophila melanogaster survival after infection with Gram-positive entomopathogenic bacterium Enterococcus faecalis is reported. There was considerable defense against E. among inbred lines Genetics Reference Panel. We identified single nucleotide polymorphisms associated six genes significant (p <...
Background: Absorbable metallic stents (AMS) utilizing Mg alloy carry advantages over permanent because of their potential to eliminate stent thrombosis, chronic inflammation, or artifacts with noninvasive imaging. These stents, however, are associated a modest degree late recoil and intimal hyperplasia. The aim the study was test whether adjunct vascular brachytherapy (VBT) compared AMS alone can overcome these limitations. Methods: Juvenile domestic pig coronary arteries underwent...
In small clinical trials, sympathetic renal denervation using radiofrequency (RF) energy shows promise in treating resistant hypertension. However, the RF procedure is lengthy and associated with pain during ablation. Vascular brachytherapy, a proven treatment for in-stent restenosis, has potential to cause nerve fibrosis. The purpose of present study was assess safety feasibility artery brachytherapy denervation.A total 10 normotensive domestic swine underwent vascular left right arteries...