A5008048551- Advanced Radiotherapy Techniques
- Medical Imaging Techniques and Applications
- Advanced X-ray and CT Imaging
- Radiation Dose and Imaging
- Radiation Therapy and Dosimetry
- Radiomics and Machine Learning in Medical Imaging
- Lung Cancer Diagnosis and Treatment
- Advanced MRI Techniques and Applications
- Advances in Oncology and Radiotherapy
- MRI in cancer diagnosis
- Digital Radiography and Breast Imaging
- Medical Imaging and Analysis
- Prostate Cancer Diagnosis and Treatment
- Nanoparticle-Based Drug Delivery
- Nanoplatforms for cancer theranostics
- Cancer, Hypoxia, and Metabolism
- Management of metastatic bone disease
- Medical Image Segmentation Techniques
- Radiation Effects and Dosimetry
- Glioma Diagnosis and Treatment
- Head and Neck Cancer Studies
- Radiopharmaceutical Chemistry and Applications
- Spinal Fractures and Fixation Techniques
- Radiation Detection and Scintillator Technologies
- Photoacoustic and Ultrasonic Imaging
The University of Texas MD Anderson Cancer Center
2019-2024
University of Toronto
2014-2023
Princess Margaret Cancer Centre
2014-2023
University Health Network
2013-2022
Toronto Public Health
2012-2020
Mount Sinai Hospital
2019-2020
Ontario Institute for Cancer Research
2008-2017
National Cancer Institute
2017
Princess Margaret Cancer Foundation
2017
West Virginia University
2017
Among other nanoparticle systems, gold nanoparticles have been explored as radiosensitizers. While most of the research in this area has focused on either with diameters less than 2 nm or particles micrometer dimensions, it shown that 50 diameter highest cellular uptake. We present results vitro studies focus radiosensitization properties size range from 14-74 nm. Radiosensitization was dependent number internalized within cells. Gold 50-nm showed enhancement factor (REF) (1.43 at 220 kVp)...
A system for cone-beam computed tomography (CBCT) based on a flat-panel imager (FPI) is used to examine the magnitude and effects of x-ray scatter in FPI-CBCT volume reconstructions. The being developed application image-guided therapies has previously demonstrated spatial resolution soft-tissue visibility comparable or superior conventional CT scanner under conditions low scatter. For larger objects consistent with imaging human anatomy (e.g., pelvis) increased cone angle (i.e., volumetric...
The development and performance of a system for x‐ray cone‐beam computed tomography (CBCT) using an indirect‐detection flat‐panel imager (FPI) is presented. Developed as bench‐top prototype initial investigation FPI‐based CBCT bone soft‐tissue localization in radiotherapy, the provides fully three‐dimensional volumetric image data from projections acquired during single rotation. employs 512×512 active matrix thin‐film transistors photodiodes combination with luminescent phosphor....
As more pretreatment imaging becomes integrated into the treatment planning process and full three-dimensional image-guidance part of delivery need for a deformable image registration technique apparent. A novel finite element model-based multiorgan method, MORFEUS, has been developed. The basis this method is twofold: first, individual organ deformation can be accurately modeled by deforming surface at one instance another assigning material properties that allow internal structures to...
Refinement of radiomic results and methodologies is required to ensure progression the field. In this work, we establish a set safeguards designed improve support current through detailed analysis signature.A model (MW2018) was fitted externally validated using features extracted from previously reported lung head neck (H&N) cancer datasets gross-tumour-volume contours, as well images with randomly permuted voxel index values; i.e. without meaningful texture. To determine MW2018's added...
The aim of this study is to understand the characteristics secondary electrons generated from interaction gold nanoparticles (GNPs) with x-rays as a function nanoparticle size and beam energy thereby further understanding GNP-enhanced radiotherapy.The effective range, deflection angle, dose deposition, energy, processes produced GNP were calculated by Monte Carlo simulations. GEANT4 code was used simulate track 2, 50, 100 nm diameter when it irradiated 50 kVp, 250 cobalt-60, 6 MV photon in...
Purpose: Interest in adaptive radiation therapy research is constantly growing, but software tools available for researchers are mostly either expensive, closed proprietary applications, or free open‐source packages with limited scope, extensibility, reliability, user support. To address these limitations, we propose SlicerRT, a customizable, free, and toolkit. SlicerRT aspires to be an toolkit RT research, providing fast computations, convenient workflows researchers, general image‐guided...
Abstract BACKGROUND: This study sought to determine if preoperative image‐guided intensity‐modulated radiotherapy (IG‐IMRT) can reduce morbidity, including wound complications, by minimizing dose uninvolved tissues in adults with lower extremity soft tissue sarcoma. METHODS: The primary endpoint was the development of an acute complication (WC). IG‐IMRT used conform volumes avoid normal (skin flaps for closure, bone, or other tissues). From July 2005 June 2009, 70 were enrolled; 59 evaluable...
Only around 20-30% of patients with non-small-cell lung cancer (NCSLC) have durable benefit from immune-checkpoint inhibitors. Although tissue-based biomarkers (eg, PD-L1) are limited by suboptimal performance, tissue availability, and tumour heterogeneity, radiographic images might holistically capture the underlying biology. We aimed to investigate application deep learning on chest CT scans derive an imaging signature response immune checkpoint inhibitors evaluate its added value in...
Abstract While we recognize the prognostic importance of clinicopathological measures and circulating tumor DNA (ctDNA), independent contribution quantitative image markers to prognosis in non-small cell lung cancer (NSCLC) remains underexplored. In our multi-institutional study 394 NSCLC patients, utilize pre-treatment computed tomography (CT) 18 F-fluorodeoxyglucose positron emission (FDG-PET) establish a habitat imaging framework for assessing regional heterogeneity within individual...
Kilovoltage cone-beam computerized tomography (kV-CBCT) systems integrated into the gantry of linear accelerators can be used to acquire high-resolution volumetric images patient in treatment position. Using on-line software and hardware, position determined accurately with a high degree precision and, subsequently, set-up parameters adjusted deliver intended treatment. While dose due single imaging acquisition is small compared therapy dose, repeated daily image guidance procedures lead...