A5060444850- Osteoarthritis Treatment and Mechanisms
- Sarcoma Diagnosis and Treatment
- Knee injuries and reconstruction techniques
- Spine and Intervertebral Disc Pathology
- Bone Tumor Diagnosis and Treatments
- Periodontal Regeneration and Treatments
- Vascular Tumors and Angiosarcomas
- Musculoskeletal pain and rehabilitation
- Bone Tissue Engineering Materials
- Cell Adhesion Molecules Research
- Silk-based biomaterials and applications
- Orthopaedic implants and arthroplasty
- Total Knee Arthroplasty Outcomes
- Mesenchymal stem cell research
- Bone health and treatments
- Cancer-related Molecular Pathways
- Proteoglycans and glycosaminoglycans research
- Inflammatory mediators and NSAID effects
- Tendon Structure and Treatment
- Cardiac tumors and thrombi
- Musculoskeletal synovial abnormalities and treatments
- Soft tissue tumors and treatment
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Reconstructive Surgery and Microvascular Techniques
- biodegradable polymer synthesis and properties
University of California, Davis
2024-2025
Duke University Hospital
2025
Duke Medical Center
2017-2025
University of Toronto
2015-2024
University of Pennsylvania
2018-2024
Mount Sinai Hospital
2014-2024
Lunenfeld-Tanenbaum Research Institute
2015-2024
AO Foundation
2018-2023
Tokai University
2018-2023
Agriculture and Forestry University
2023
Mainil-Varlet, Pierre MD, PhD; Aigner, Thomas MD; Brittberg, Mats Bullough, Peter Hollander, Anthony Hunziker, Ernst Kandel, Rita Nehrer, Stefan Pritzker, Kenneth Roberts, Sally Stauffer, Edouard MD Author Information
Background A reliable and reproducible method is needed to assess cartilage repair. Purpose This study was undertaken test the reproducibility of 2 established histological scoring systems, Modified O'Driscoll Scale (MODS) International Cartilage Research Society (ICRS) Visual Assessment (ICRS I), subsequently develop evaluate a new grading system for Study Design Cohort study; Level evidence, 2. Methods total 107 biopsy specimens were graded using MODS ICRS I, reader variability measured....
ABSTRACT Low back pain is a major physical and socioeconomic problem. Degeneration of the intervertebral disc especially that nucleus pulposus (NP) has been linked to low pain. In spite much research focusing on NP, consensus among community lacking in defining NP cell phenotype. A agreement will allow easier distinguishing cells from annulus fibrosus (AF) endplate chondrocytes, better gauge therapeutic success, guidance tissue‐engineering‐based regenerative strategies attempt replace lost...
Abstract BACKGROUND: This study sought to determine if preoperative image‐guided intensity‐modulated radiotherapy (IG‐IMRT) can reduce morbidity, including wound complications, by minimizing dose uninvolved tissues in adults with lower extremity soft tissue sarcoma. METHODS: The primary endpoint was the development of an acute complication (WC). IG‐IMRT used conform volumes avoid normal (skin flaps for closure, bone, or other tissues). From July 2005 June 2009, 70 were enrolled; 59 evaluable...
Background: The use of curettage, phenol, and cement is accepted by most experts as the best treatment for giant-cell tumor bone. present study was performed to evaluate whether equivalent results could be obtained with curettage a high-speed burr reconstruction resulting defect autogenous bone graft or without allograft bone.Methods: prospectively collected records patients who had long were reviewed determine rate local recurrence after All followed clinically radiographically, biopsy if...
Sixty-five patients who had been referred to our unit for additional management after an unplanned excision of a soft-tissue sarcoma extremity at another institution were studied retrospectively determine the prevalence residual tumor and identify factors that predict which will have following such excision. Unplanned was defined as excisional biopsy or resection lesion without benefit preoperative imaging regard necessity resect with margin normal tissue. In each patient, histological...
Morbidity associated with wound complications may translate into disability and quality-of-life disadvantages for patients treated radiotherapy (RT) soft tissue sarcoma (STS) of the extremities. Functional outcome health status extremity STS randomized in a phase III trial comparing preoperative versus postoperative RT is described.One hundred ninety were after stratification by tumor size dichotomized at 10 cm. Function quality life measured Musculoskeletal Tumor Society Rating Scale...
This study examines changes in the production of extracellular matrix molecules as well induction tissue degradation vitro formed nucleus pulposus (NP) tissues following incubation with tumor necrosis factor (TNF)alpha.To characterize response NP cells to TNF-alpha, a proinflammatory cytokine present herniated tissues.TNF-alpha is expressed by degenerate intervertebral discs. It implicated pain associated disc herniation, although its role degeneration remains poorly understood.In were...
We considered whether a positive margin occurring after resection of soft-tissue sarcoma limb would affect the incidence local recurrence. Patients with low-grade liposarcomas were expected to be low-risk group as those who had margins planned before surgery preserve critical structures. Two groups, however, at higher risk, namely, patients undergone unplanned excision elsewhere on re-excision and during primary resection. Of 566 in prospective database, 87 limb-sparing adjuvant radiotherapy...
Abstract Although many cancers are maintained by tumor-initiating cells, this has not been shown for mesenchymal tumors, in part due to the lack of unique surface markers that identify progenitors. An alternative technique isolate stem-like cells is side population (SP) based on efflux Hoechst 33342 dye. We examined 29 tumors ranging from benign high-grade sarcomas and identified SP all but six samples. There was a positive correlation between percentage grade tumor. preferentially formed...
The formation of cartilaginous tissue in vitro is a promising alternative to repair damaged articular cartilage. However, recent attempts tissue-engineer cartilage that has similar properties the native have proven be difficult. vitro-formed typically proteoglycan content cartilage, but reduced collagen and only fraction mechanical properties. In this study, we investigated whether intermittent application cyclic shearing forces during would improve quality. Chondrocyte cultures were...
To prospectively assess T2 mapping characteristics of normal articular cartilage and at sites arthroscopic repair, including comparison with histologic results collagen organization assessed polarized light microscopy (PLM).Study protocol was compliant the Canadian Council on Animal Care Guidelines approved by institutional animal care committee. Arthroscopic osteochondral autograft transplantation (OAT) microfracture arthroplasty (MFx) were performed in knees 10 equine subjects (seven...
Abstract BACKGROUND: Myxoid liposarcoma has been reported to be more radiosensitive compared with other soft tissue sarcomas (STS). The authors report the results of multidisciplinary treatment extremity myxoid a contemporary cohort STS subtypes an emphasis on role radiotherapy (RT) in improving local control. METHODS: Between 1989 and 2004, 691 patients were identified from prospective database who underwent combined management for localized followed minimum 12 months or until death. All...