A5037659354- Advanced Radiotherapy Techniques
- Hepatocellular Carcinoma Treatment and Prognosis
- Medical Imaging Techniques and Applications
- Radiation Therapy and Dosimetry
- Head and Neck Cancer Studies
- Management of metastatic bone disease
- Radiomics and Machine Learning in Medical Imaging
- Lung Cancer Diagnosis and Treatment
- Pancreatic and Hepatic Oncology Research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Radiation Dose and Imaging
- Salivary Gland Tumors Diagnosis and Treatment
- Brain Metastases and Treatment
- Liver Disease Diagnosis and Treatment
- Cancer Diagnosis and Treatment
- Head and Neck Surgical Oncology
- Advanced X-ray and CT Imaging
- MRI in cancer diagnosis
- Advanced MRI Techniques and Applications
- Gastric Cancer Management and Outcomes
- Effects of Radiation Exposure
- Colorectal and Anal Carcinomas
- Advances in Oncology and Radiotherapy
- Gallbladder and Bile Duct Disorders
- Lung Cancer Treatments and Mutations
University of Toronto
2016-2025
Princess Margaret Cancer Centre
2016-2025
University Health Network
2016-2025
Memorial University of Newfoundland
2022-2025
McMaster University
2021
Regional Municipality of Waterloo
2021
Humanitas University
2020
Toronto General Hospital
2007-2020
North Shore Hospital
2020
University of Nottingham
2018
Purpose To describe outcomes of prospective trials stereotactic body radiotherapy (SBRT) for hepatocellular carcinoma (HCC). Patients and Methods Two SBRT patients with active HCC unsuitable standard locoregional therapies were conducted from 2004 to 2010. All had Child-Turcotte-Pugh class A disease, at least 700 mL non-HCC liver. The dose range was 24 54 Gy in six fractions. Primary end points toxicity local control 1 year (LC1y), defined as no progressive disease (PD) irradiated by RECIST...
To report outcomes of a phase I study individualized stereotactic body radiotherapy treatment (SBRT) for unresectable hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (IHC).Patients with HCC or IHC, who are not suitable standard therapies, were eligible six-fraction SBRT during 2 weeks. Radiation dose was dependent on the volume liver irradiated estimated risk toxicity based normal tissue complication model. Toxicity escalated from 5% to 10% 20%, within three...
To define human papillomavirus (HPV) -positive oropharyngeal cancers (OPC) suitable for treatment deintensification according to low risk of distant metastasis (DM).OPC treated with radiotherapy (RT) or chemoradiotherapy (CRT) from 2001 2009 were included. Outcomes compared HPV-positive versus HPV-negative patients. Univariate and multivariate analyses identified outcome predictors. Recursive partitioning analysis (RPA) stratified the DM risk.HPV status was ascertained in 505 (56%) 899...
To report on the outcomes of a phase I study stereotactic body radiotherapy (SBRT) for treatment liver metastases.Patients with metastases that were inoperable or medically unsuitable resection, and who not candidates standard therapies, eligible this individualized SBRT. Individualized radiation doses chosen to maintain same nominal risk radiation-induced disease (RILD) three estimated levels (5%, 10%, 20%). Additional patients treated at maximal dose (MSD) in an expanded cohort. Median...
As more pretreatment imaging becomes integrated into the treatment planning process and full three-dimensional image-guidance part of delivery need for a deformable image registration technique apparent. A novel finite element model-based multiorgan method, MORFEUS, has been developed. The basis this method is twofold: first, individual organ deformation can be accurately modeled by deforming surface at one instance another assigning material properties that allow internal structures to...
The role of postoperative therapy in extrahepatic cholangiocarcinoma (EHCC) or gallbladder carcinoma (GBCA) is unknown. S0809 was designed to estimate 2-year survival (overall and after R0 R1 resection), pattern relapse, toxicity patients treated with this adjuvant regimen.Eligibility criteria included diagnosis EHCC GBCA radical resection, stage pT2-4 N+ positive resection margins, M0, performance status 0 1. Patients received four cycles gemcitabine (1,000 mg/m(2) intravenously on days 1...
We compared the outcome of breast-conserving surgery and radiotherapy in BRCA1/2 mutation carriers with breast cancer versus that matched sporadic controls.A total 160 were 445 controls cancer. Primary end points rates in-breast tumor recurrence (IBTR) contralateral cancers (CBCs). Median follow-up was 7.9 years for 6.7 controls.There no significant difference IBTR overall between controls; 10- 15-year estimates 12% 24% 9% 17% controls, respectively (hazard ratio [HR], 1.37; P = .19)....
A significant proportion of oropharyngeal squamous cell carcinomas (OSCC) are associated with the human papilloma virus (HPV), particularly HPV16. The optimal method for HPV determination on archival materials however, remains unclear. We compared a quantitative real-time polymerase chain reaction (qRT-PCR) assay HPV16 mRNA to DNA in situ hybridization (ISH) method, and evaluated their significance overall (OS) disease-free (DFS) survival.Matched, biopsies from 111 patients OSCC were using...
Abstract BACKGROUND: This study was undertaken to determine outcomes of stereotactic body radiotherapy for colorectal liver metastases in a pooled patient cohort. METHODS: Patients with from 3 institutions were included if they had 1 4 lesions, received 6 fractions radiotherapy, and radiologic imaging ≥3 months post‐treatment. Sixty‐five patients 102 lesions treated August 2003 May 2009 retrospectively analyzed. A tumor control probability (TCP) model used estimate the 3‐fraction dose...
Little is known of the incidence shoulder instability, despite some evidence that it may be a common injury in young, athletic individuals. The goal this study was to determine dislocation United States military personnel, as well identify demographic risk factors for injury.We performed query Defense Medical Epidemiology Database with code from International Classification Diseases, Ninth Revision, acute years 1998 through 2006. An overall calculated, addition multivariate analysis,...