A5057224046- Endometrial and Cervical Cancer Treatments
- Ovarian cancer diagnosis and treatment
- Cervical Cancer and HPV Research
- Advanced Radiotherapy Techniques
- Uterine Myomas and Treatments
- Breast Cancer Treatment Studies
- Management of metastatic bone disease
- Colorectal and Anal Carcinomas
- Advances in Oncology and Radiotherapy
- Endometriosis Research and Treatment
- Lymphoma Diagnosis and Treatment
- Multiple and Secondary Primary Cancers
- Cancer Risks and Factors
- Global Cancer Incidence and Screening
- Cancer survivorship and care
- Radiomics and Machine Learning in Medical Imaging
- Radiation Therapy and Dosimetry
- BRCA gene mutations in cancer
- Sarcoma Diagnosis and Treatment
- Cutaneous lymphoproliferative disorders research
- Breast Lesions and Carcinomas
- Lung Cancer Treatments and Mutations
- Estrogen and related hormone effects
- Cancer Diagnosis and Treatment
- Effects of Radiation Exposure
Huntsman Cancer Institute
2016-2025
University of Utah
2016-2025
Cleveland Clinic
2023-2024
Cancer Institute (WIA)
2023-2024
University Hospitals Seidman Cancer Center
2023-2024
Stanford University
2023
International Federation of Gynaecology and Obstetrics
2023
Huntsman (United States)
2007-2022
Suwon Research Institute
2016-2020
Istituto Nazionale di Fisica Nucleare, Sezione di Milano
2013-2020
Cervical cancer is a malignant epithelial tumor that forms in the uterine cervix. Most cases of cervical are preventable through human papilloma virus (HPV) vaccination, routine screening, and treatment precancerous lesions. However, due to inadequate screening protocols many regions world, remains fourth-most common women globally. The complete NCCN Guidelines for Cancer provide recommendations diagnosis, evaluation, cancer. This manuscript discusses guiding principles workup, staging,...
Endometrial carcinoma is a malignant epithelial tumor that forms in the inner lining, or endometrium, of uterus. most common gynecologic malignancy. Approximately two-thirds endometrial cases are diagnosed with disease confined to The complete NCCN Guidelines for Uterine Neoplasms provide recommendations diagnosis, evaluation, and treatment cancer uterine sarcoma. This manuscript discusses guiding principles staging, early-stage as well evidence these recommendations.
Abstract Introduction Many advances in the understanding of pathologic and molecular features endometrial cancer have occurred since FIGO staging was last updated 2009. Substantially more outcome biological behavior data are now available regarding several histological types. Molecular genetic findings accelerated publication The Cancer Genome Atlas (TCGA) provide improved clarity on diverse nature this collection cancers their differing prognostic outcomes. goals new system to better define...
Adenocarcinoma of the endometrium (also known as endometrial cancer, or more broadly uterine cancer carcinoma corpus) is most common malignancy female genital tract in United States. It estimated that 65,950 new cases will have occurred 2022, with 12,550 deaths resulting from disease. Endometrial includes pure endometrioid and carcinomas high-risk histology (including serous carcinoma, clear cell carcinosarcoma [also malignant mixed Müllerian tumor], undifferentiated/dedifferentiated...
We compared the outcome of breast-conserving surgery and radiotherapy in BRCA1/2 mutation carriers with breast cancer versus that matched sporadic controls.A total 160 were 445 controls cancer. Primary end points rates in-breast tumor recurrence (IBTR) contralateral cancers (CBCs). Median follow-up was 7.9 years for 6.7 controls.There no significant difference IBTR overall between controls; 10- 15-year estimates 12% 24% 9% 17% controls, respectively (hazard ratio [HR], 1.37; P = .19)....
The NCCN Guidelines for Cervical Cancer provide interdisciplinary recommendations treating cervical cancer. These Insights summarize the Panel’s discussion and major guideline updates from 2014 2015. recommended systemic therapy options recurrent metastatic cancer were amended upon panel review of new survival data FDA’s approval bevacizumab late-stage This article outlines relevant provides insight into decisions regarding various combination regimens. Additionally, a section was added to...
The NCCN Guidelines for Cervical Cancer provide recommendations diagnostic workup, staging, and treatment of patients with the disease. These Insights focus on recent updates to guidelines, including changes first- second-line systemic therapy recurrent or metastatic disease, emerging evidence a new histopathologic classification system HPV-related endocervical adenocarcinoma.
Purpose NRG Oncology/RTOG 1203 was designed to compare patient-reported acute toxicity and health-related quality of life during treatment with standard pelvic radiation or intensity-modulated therapy (IMRT) in women cervical endometrial cancer. Methods Patients were randomly assigned four-field (RT) IMRT treatment. The primary end point change GI from baseline the RT, measured bowel domain Expanded Prostate Cancer Index Composite (EPIC). Secondary points included urinary toxicity,...
The NCCN Guidelines for Uterine Neoplasms provide recommendations diagnostic workup, clinical staging, and treatment options patients with endometrial cancer or uterine sarcoma. These Insights focus on the recent addition of molecular profiling information to aid in accurate diagnosis, classification, sarcomas.
Introduction: Many advances in the understanding of pathologic and molecular features endometrial cancer have occurred since FIGO staging was last updated 2009.Substantially more outcome biological behavior data are now available regarding several histological types.Molecular genetic findings accelerated publication The Cancer Genome Atlas (TCGA) provide improved clarity on diverse nature this collection cancers their differing prognostic outcomes.The goals new system to better define these...
The NCCN Guidelines for Cervical Cancer provide recommendations all aspects of management cervical cancer, including the diagnostic workup, staging, pathology, and treatment. guidelines also include details on histopathologic classification cancer regarding features, molecular profiles, clinical outcomes. treatment landscape advanced is evolving constantly. These Insights a summary recent updates systemic therapy recurrent or metastatic disease.
Vulvar cancer is annually diagnosed in an estimated 6,470 individuals and the vast majority are histologically squamous cell carcinomas. accounts for 5% to 8% of gynecologic malignancies. Known risk factors vulvar include increasing age, infection with human papillomavirus, cigarette smoking, inflammatory conditions affecting vulva, immunodeficiency. Most neoplasias at early stages. Rarer histologies exist melanoma, extramammary Paget’s disease, Bartholin gland adenocarcinoma, verrucous...
PURPOSE: Recent laboratory data suggest a role for BRCA1/2 in the cellular response to DNA damage. There is paucity of clinical data, however, examining effect radiotherapy (RT), which causes double-strand breaks, on breast tissue from mutation carriers. Thus goals this study were compare rates radiation-associated complications, in-breast tumor recurrence, and distant relapse women with mutations treated breast-conserving therapy (BCT) using RT observed sporadic disease. PATIENTS AND...
Malignant phyllodes tumor is a rare and potentially aggressive breast neoplasm. Little information available regarding the optimal management of these lesions rarer still are data survival. The current study used large population database to determine prognostic factors that predict cause-specific survival (CSS).Data were obtained from Surveillance, Epidemiology, End Results Program (SEER) for years 1983-2002. Women receiving resection primary nonmetastatic malignant included (n = 821)....
Abstract BACKGROUND Survivors of non‐Hodgkin lymphoma (NHL) are at increased risk for developing secondary malignancies. For the current study, authors quantitated this in a group NHL survivors over 30 years follow‐up. METHODS Standardized incidence ratios (observed‐to‐expected [O/E] ratio) and absolute excess malignancies were assessed 77,876 patients who diagnosed with between 1973 2001 from centers that participated National Cancer Institute's Surveillance, Epidemiology, End Results...
To compare the incidence, mortality, and presentation of small cell carcinoma cervix with other histologies.From 1977 to 2003, 290 women uteri were identified from Surveillance, Epidemiology, End Results database. Also, 27,527 patients squamous 5,231 adenocarcinoma for comparison. The annual incidence was calculated examined trend. Patient disease characteristics compared among histologies. Univariable analyses conducted using log-rank test. Multivariable analysis performed Cox...